Y
Yongqian Zhao
Researcher at National University of Singapore
Publications - 20
Citations - 1041
Yongqian Zhao is an academic researcher from National University of Singapore. The author has contributed to research in topics: Dengue virus & Viral replication. The author has an hindex of 15, co-authored 20 publications receiving 858 citations. Previous affiliations of Yongqian Zhao include Nanyang Technological University & Hong Kong University of Science and Technology.
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Journal ArticleDOI
A Crystal Structure of the Dengue Virus NS5 Protein Reveals a Novel Inter-domain Interface Essential for Protein Flexibility and Virus Replication
Yongqian Zhao,Tingjin Sherryl Soh,Jie Zheng,Kitti Wing Ki Chan,Wint Wint Phoo,Chin Chin Lee,Moon Y. F. Tay,Kunchithapadam Swaminathan,Tobias Cornvik,Siew Pheng Lim,Pei Yong Shi,Julien Lescar,Subhash G. Vasudevan,Dahai Luo +13 more
TL;DR: A picture for the molecular origin of NS5 flexibility is emerging with profound implications for flavivirus replication and for the development of therapeutics targeting NS5.
Journal ArticleDOI
The C-terminal 50 amino acid residues of dengue NS3 protein are important for NS3-NS5 interaction and viral replication.
Moon Y. F. Tay,Wuan Geok Saw,Yongqian Zhao,Kitti Wing Ki Chan,Daljit Singh,Yuwen Chong,Jade K. Forwood,Eng Eong Ooi,Gerhard Grüber,Julien Lescar,Dahai Luo,Subhash G. Vasudevan +11 more
TL;DR: The identification of the functionally essential interaction between the two proteins by biochemical and reverse genetics methods paves the way for rational drug design efforts to inhibit viral RNA synthesis.
Journal ArticleDOI
Structure of the origin recognition complex bound to DNA replication origin
Ningning Li,Wai Hei Lam,Yuanliang Zhai,Yuanliang Zhai,Jiaxuan Cheng,Erchao Cheng,Yongqian Zhao,Ning Gao,Bik Kwoon Tye,Bik Kwoon Tye +9 more
TL;DR: A conserved role of ORC is pinpoints in modulating DNA structure to facilitate origin selection and helicase loading in eukaryotes and provides insights into the basis of the origin selection mechanism.
Journal ArticleDOI
Anisotropic two-dimensional electron gas at the LaAlO3/SrTiO3 (110) interface
Anil Annadi,Qinfang Zhang,X. Renshaw Wang,Nikolina Tuzla,Kalon Gopinadhan,W. M. Lü,A. Roy Barman,Zhiqi Liu,Amar Srivastava,Surajit Saha,Yongqian Zhao,Shengwei Zeng,Sankar Dhar,Eva Olsson,Bo Gu,Seiji Yunoki,Sadamichi Maekawa,Hans Hilgenkamp,Hans Hilgenkamp,Thirumalai Venkatesan,Ariando +20 more
TL;DR: In this paper, the authors reported the observation of unexpected conductivity at the LaAlO3/SrTiO3 interface prepared on (110)-oriented SrTiO 3, with a LaO3-layer thickness-dependent metal-insulator transition.
Journal ArticleDOI
The C-terminal 18 Amino Acid Region of Dengue Virus NS5 Regulates its Subcellular Localization and Contains a Conserved Arginine Residue Essential for Infectious Virus Production
Moon Y. F. Tay,Kate Smith,Ivan Ng,Kitti Wing Ki Chan,Yongqian Zhao,Eng Eong Ooi,Julien Lescar,Julien Lescar,Dahai Luo,David A. Jans,Jade K. Forwood,Subhash G. Vasudevan +11 more
TL;DR: An evolutionarily conserved function for NS5 Cter18 is suggested, possibly in RNA interactions that are critical for replication, that is independent of its role in subcellular localization.