Institution
Guy's and St Thomas' NHS Foundation Trust
Healthcare•London, United Kingdom•
About: Guy's and St Thomas' NHS Foundation Trust is a healthcare organization based out in London, United Kingdom. It is known for research contribution in the topics: Population & Medicine. The organization has 7686 authors who have published 9631 publications receiving 399353 citations. The organization is also known as: Guy's and St Thomas' National Health Service Foundation Trust & Guy's and St Thomas' National Health Service Trust.
Topics: Population, Medicine, Randomized controlled trial, Cancer, Breast cancer
Papers published on a yearly basis
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TL;DR: There is still a lack of suitable biomarkers or clinical endpoints that can be used to determine vitamin K requirements among adults, and there is a need for stable isotope studies with enhanced sensitivity to expand knowledge of the bioavailability, absorption, disposition, and metabolism of different molecular forms of vitamin K.
241 citations
TL;DR: This review found no published evidence for or against the use of NSAIDs in COVID-19 patients, and there appeared to be some evidence that corticosteroids may be beneficial if utilised in the early acute phase of infection, however, conflicting evidence from the World Health Organisation surrounding corticosterone use in certain viral infections means this evidence is not conclusive.
Abstract: Given the current SARS-CoV-2 (COVID-19) pandemic, the availability of reliable information for clinicians and patients is paramount. There have been a number of reports stating that non-steroidal anti-inflammatory drugs (NSAIDs) and corticosteroids may exacerbate symptoms in COVID-19 patients. Therefore, this review aimed to collate information available in published articles to identify any evidence behind these claims with the aim of advising clinicians on how best to treat patients. This review found no published evidence for or against the use of NSAIDs in COVID-19 patients. Meanwhile, there appeared to be some evidence that corticosteroids may be beneficial if utilised in the early acute phase of infection, however, conflicting evidence from the World Health Organisation surrounding corticosteroid use in certain viral infections means this evidence is not conclusive. Given the current availability of literature, caution should be exercised until further evidence emerges surrounding the use of NSAIDs and corticosteroids in COVID-19 patients.
240 citations
University of Patras1, University of Bristol2, University of Copenhagen3, University of Mainz4, Autonomous University of Barcelona5, Guy's and St Thomas' NHS Foundation Trust6, University of London7, I.M. Sechenov First Moscow State Medical University8, Lund University9, University of Porto10, Imperial College London11, University of Nicosia12, University of Oslo13, Freeman Hospital14, Newcastle University15, Nova Southeastern University16, University of Liège17, Ghent University18, Uppsala University19, Mayo Clinic20, Inova Fairfax Hospital21, Erasmus University Rotterdam22
TL;DR: The European Society for Vascular Surgery (ESVS) 2021 Clinical Practice Guidelines on the Management of Venous Thrombosis as discussed by the authors have been published for the management of venous thrombotic vessels.
240 citations
TL;DR: It is shown that steady-state levels of transcripts encoding the α-SNS subunit are reduced significantly 5 days following axotomy of DRG neurons, and continue to be expressed at reduced levels, even after 210 days, which may explain the selective loss of slowly inactivating, TTX-R current.
Abstract: Spinal sensory (dorsal root ganglion; DRG) neurons display slowly
inactivating, tetrodotoxin-resistant (TTX-R), and rapidly inactivating,
TTX-sensitive (TTX-S) Na currents. Attenuation of the TTX-R Na current
and enhancement of TTX-S Na current have been demonstrated in cutaneous
afferent DRG neurons in the adult rat after axotomy and may underlie
abnormal bursting. We show here that steady-state levels of transcripts
encoding the α-SNS subunit, which is associated with a slowly
inactivating, TTX-R current when expressed in oocytes, are reduced
significantly 5 days following axotomy of DRG neurons, and continue to
be expressed at reduced levels, even after 210 days. Steady-state
levels of α-III transcripts, which are present at low levels in
control DRG neurons, show a pattern of transiently increased
expression. In situ hybridization using α-SNS- and
α-III-specific riboprobes showed a decreased signal for α-SNS, and
an increased signal for α-III, in both large and small DRG neurons
following axotomy. Reduced levels of α-SNS may explain the selective
loss of slowly inactivating, TTX-R current. The abnormal
electrophysiological properties of DRG neurons following axonal injury
thus appear to reflect a switch in Na channel gene expression.
238 citations
TL;DR: It is recommended that any new colloid should be introduced into clinical practice only after its patient-important safety parameters are established and not to use hyperoncotic solutions for fluid resuscitation.
Abstract: Purpose
Colloids are administered to more patients than crystalloids, although recent evidence suggests that colloids may possibly be harmful in some patients. The European Society of Intensive Care Medicine therefore assembled a task force to compile consensus recommendations based on the current best evidence for the safety and efficacy of the currently most frequently used colloids—hydroxyethyl starches (HES), gelatins and human albumin.
238 citations
Authors
Showing all 7765 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Christopher J L Murray | 209 | 754 | 310329 |
| Bruce M. Psaty | 181 | 1205 | 138244 |
| Giuseppe Remuzzi | 172 | 1226 | 160440 |
| Mika Kivimäki | 166 | 1515 | 141468 |
| Simon I. Hay | 165 | 557 | 153307 |
| Theo Vos | 156 | 502 | 186409 |
| Ali H. Mokdad | 156 | 634 | 160599 |
| Steven Williams | 144 | 1375 | 86712 |
| Igor Rudan | 142 | 658 | 103659 |
| Mohsen Naghavi | 139 | 381 | 169048 |
| Christopher D.M. Fletcher | 138 | 674 | 82484 |
| Martin McKee | 138 | 1732 | 125972 |
| David A. Jackson | 136 | 1095 | 68352 |
| Graham G. Giles | 136 | 1249 | 80038 |
| Yang Liu | 129 | 2506 | 122380 |