Institution
Guy's and St Thomas' NHS Foundation Trust
Healthcare•London, United Kingdom•
About: Guy's and St Thomas' NHS Foundation Trust is a healthcare organization based out in London, United Kingdom. It is known for research contribution in the topics: Population & Medicine. The organization has 7686 authors who have published 9631 publications receiving 399353 citations. The organization is also known as: Guy's and St Thomas' National Health Service Foundation Trust & Guy's and St Thomas' National Health Service Trust.
Topics: Population, Medicine, Randomized controlled trial, Cancer, Breast cancer
Papers published on a yearly basis
Papers
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Sergey Nejentsev1, Joanna M. M. Howson1, Neil Walker1, Jeffrey S. Szeszko1 +218 more•Institutions (26)
TL;DR: In this article, the major histocompatibility complex (MHC) on chromosome 6 is associated with susceptibility to more common diseases than any other region of the human genome, including almost all disorders classified as autoimmune.
Abstract: The major histocompatibility complex (MHC) on chromosome 6 is associated with susceptibility to more common diseases than any other region of the human genome, including almost all disorders classified as autoimmune. In type 1 diabetes the major genetic susceptibility determinants have been mapped to the MHC class II genes HLA-DQB1 and HLA-DRB1 (refs 1-3), but these genes cannot completely explain the association between type 1 diabetes and the MHC region. Owing to the region's extreme gene density, the multiplicity of disease-associated alleles, strong associations between alleles, limited genotyping capability, and inadequate statistical approaches and sample sizes, which, and how many, loci within the MHC determine susceptibility remains unclear. Here, in several large type 1 diabetes data sets, we analyse a combined total of 1,729 polymorphisms, and apply statistical methods-recursive partitioning and regression-to pinpoint disease susceptibility to the MHC class I genes HLA-B and HLA-A (risk ratios >1.5; P(combined) = 2.01 x 10(-19) and 2.35 x 10(-13), respectively) in addition to the established associations of the MHC class II genes. Other loci with smaller and/or rarer effects might also be involved, but to find these, future searches must take into account both the HLA class II and class I genes and use even larger samples. Taken together with previous studies, we conclude that MHC-class-I-mediated events, principally involving HLA-B*39, contribute to the aetiology of type 1 diabetes.
525 citations
TL;DR: This report provides national estimates of levels and trends of HIV/AIDS incidence, prevalence, coverage of antiretroviral therapy (ART), and mortality for 195 countries and territories from 1980 to 2015.
522 citations
University of Oxford1, Wellcome Trust Sanger Institute2, University of Cambridge3, Public Health England4, Liverpool School of Tropical Medicine5, University of Sheffield6, Newcastle University7, Newcastle upon Tyne Hospitals NHS Foundation Trust8, University of Southampton9, University Hospital Southampton NHS Foundation Trust10, University Hospitals Bristol NHS Foundation Trust11, St George's, University of London12, Guy's and St Thomas' NHS Foundation Trust13, University College London14, University Hospitals Birmingham NHS Foundation Trust15, University of Glasgow16, North Bristol NHS Trust17, University College Hospital18, University of Hull19, Northwest University (China)20, Glasgow Dental Hospital and School21, Western General Hospital22, University of Nottingham23, Nottingham University Hospitals NHS Trust24, AstraZeneca25, Aneurin Bevan University Health Board26, Cardiff University27
TL;DR: A post-hoc analysis of the efficacy of the adenoviral vector vaccine, ChAdOx1 nCoV-19 (AZD1222), against B.1.7, emerged as the dominant cause of COVID-19 disease in the UK from November, 2020 as discussed by the authors.
521 citations
TL;DR: In this paper, the association between compliance with the Surviving Sepsis Campaign (SSC) performance bundles and mortality was found to be a significant predictor of mortality in the US.
Abstract: Purpose
To determine the association between compliance with the Surviving Sepsis Campaign (SSC) performance bundles and mortality.
519 citations
Lenox Hill Hospital1, Duke University2, University of Insubria3, Brigham and Women's Hospital4, Guy's and St Thomas' NHS Foundation Trust5, Juntendo University6, University College London Hospitals NHS Foundation Trust7, University of Paris8, University of Manchester9, The Feinstein Institute for Medical Research10, McMaster University11
TL;DR: Early reports suggest a high incidence of VTE in hospitalized COVID‐19 patients, particularly those with severe illness, that is similar to the high VTE rates observed in patients with other viral pneumonias, including severe acute respiratory syndrome (SARS) and Middle East respiratory Syndrome (MERS‐CoV).
510 citations
Authors
Showing all 7765 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Christopher J L Murray | 209 | 754 | 310329 |
| Bruce M. Psaty | 181 | 1205 | 138244 |
| Giuseppe Remuzzi | 172 | 1226 | 160440 |
| Mika Kivimäki | 166 | 1515 | 141468 |
| Simon I. Hay | 165 | 557 | 153307 |
| Theo Vos | 156 | 502 | 186409 |
| Ali H. Mokdad | 156 | 634 | 160599 |
| Steven Williams | 144 | 1375 | 86712 |
| Igor Rudan | 142 | 658 | 103659 |
| Mohsen Naghavi | 139 | 381 | 169048 |
| Christopher D.M. Fletcher | 138 | 674 | 82484 |
| Martin McKee | 138 | 1732 | 125972 |
| David A. Jackson | 136 | 1095 | 68352 |
| Graham G. Giles | 136 | 1249 | 80038 |
| Yang Liu | 129 | 2506 | 122380 |