Institution
King's College London
Education•London, United Kingdom•
About: King's College London is a education organization based out in London, United Kingdom. It is known for research contribution in the topics: Population & Mental health. The organization has 43107 authors who have published 113125 publications receiving 4498103 citations. The organization is also known as: King's & KCL.
Papers published on a yearly basis
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King's College London1, Monash University2, Imperial College London3, Dresden University of Technology4, Anschutz Medical Campus5, Agostino Gemelli University Polyclinic6, Nanyang Technological University7, University of Pisa8, Peking University9, HealthPartners10, University of Michigan11, University of Leicester12, University of Yaoundé13, University of Montpellier14
TL;DR: A large number of patients with or at risk of diabetes and metabolic complications of preexisting diabetes, including diabetic ketoacidosis and h...
Abstract: Diabetes and Covid-19 Diabetes is associated with an increased risk of severe Covid-19. New-onset diabetes and metabolic complications of preexisting diabetes, including diabetic ketoacidosis and h...
578 citations
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TL;DR: A genome-wide search for loci associated with the upper versus the lower 5th percentiles of body mass index, height and waist-to-hip ratio as well as clinical classes of obesity, including up to 263,407 individuals of European ancestry finds a large overlap in genetic structure and the distribution of variants between traits based on extremes and the general population and little etiological heterogeneity between obesity subgroups.
Abstract: Approaches exploiting trait distribution extremes may be used to identify loci associated with common traits, but it is unknown whether these loci are generalizable to the broader population. In a genome-wide search for loci associated with the upper versus the lower 5th percentiles of body mass index, height and waist-to-hip ratio, as well as clinical classes of obesity, including up to 263,407 individuals of European ancestry, we identified 4 new loci (IGFBP4, H6PD, RSRC1 and PPP2R2A) influencing height detected in the distribution tails and 7 new loci (HNF4G, RPTOR, GNAT2, MRPS33P4, ADCY9, HS6ST3 and ZZZ3) for clinical classes of obesity. Further, we find a large overlap in genetic structure and the distribution of variants between traits based on extremes and the general population and little etiological heterogeneity between obesity subgroups.
576 citations
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National Institutes of Health1, Istanbul University2, University of Texas MD Anderson Cancer Center3, University of Birmingham4, Northwestern University5, Athens Regional Medical Center6, King's College London7, Queen Mary University of London8, University of Manchester9, KAIST10, Yonsei University11
TL;DR: The known association of Behçet's disease with HLA-B*51 was confirmed and a second, independent association within the MHC Class I region was identified and the disease-associated IL10 variant was associated with diminished mRNA expression and low protein production.
Abstract: Behcet's disease is a genetically complex disease of unknown etiology characterized by recurrent inflammatory attacks affecting the orogenital mucosa, eyes and skin. We performed a genome-wide association study with 311,459 SNPs in 1,215 individuals with Behcet's disease (cases) and 1,278 healthy controls from Turkey. We confirmed the known association of Behcet's disease with HLA-B*51 and identified a second, independent association within the MHC Class I region. We also identified an association at IL10 (rs1518111, P = 1.88 x 10(-8)). Using a meta-analysis with an additional five cohorts from Turkey, the Middle East, Europe and Asia, comprising a total of 2,430 cases and 2,660 controls, we identified associations at IL10 (rs1518111, P = 3.54 x 10(-18), odds ratio = 1.45, 95% CI 1.34-1.58) and the IL23R-IL12RB2 locus (rs924080, P = 6.69 x 10(-9), OR = 1.28, 95% CI 1.18-1.39). The disease-associated IL10 variant (the rs1518111 A allele) was associated with diminished mRNA expression and low protein production.
576 citations
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TL;DR: The central hypothesis which is emerging is that the balance between nitric oxide and superoxide generation is a critical determinant in the aetiology of many human diseases including atherosclerosis, neurodegenerative disease, ischaemia‐reperfusion and cancer.
574 citations
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TL;DR: The rising trends in overweight and obesity in children in the United Kingdom are likely to be reflected in increases in adult obesity and associated morbidity.
Abstract: Objectives: To report trends in overweight and obesity, defined by new internationally agreed cut-off points, in children in the United Kingdom. Design: Three independent cross sectional surveys. Setting: Primary schools in England and Scotland. Participants: 10 414 boys and 9737 girls in England and 5385 boys and 5219 girls in Scotland aged 4 to 11 years. Main outcome measures: Prevalence and change in prevalence of overweight and obesity, as defined by the international obesity task force, in 1974, 1984, and 1994, for each sex and country. Results: Little change was found in the prevalence of overweight or obesity from 1974 to 1984. From 1984 to 1994 overweight increased from 5.4% to 9.0% in English boys (increase 3.6%, 95% confidence interval 2.3% to 5.0%) and from 6.4% to 10.0% in Scottish boys (3.6%, 1.9% to 5.4%). Values for girls were 9.3% to 13.5% (4.1%, 2.4% to 5.9%) and 10.4% to 15.8% (5.4%, 3.2% to 7.6%), respectively. The prevalence of obesity increased correspondingly, reaching 1.7% (English boys), 2.1% (Scottish boys), 2.6% (English girls), and 3.2% (Scottish girls). Conclusion: These results form a base from which trends can be monitored. The rising trends are likely to be reflected in increases in adult obesity and associated morbidity.
574 citations
Authors
Showing all 43962 results
Name | H-index | Papers | Citations |
---|---|---|---|
Cyrus Cooper | 204 | 1869 | 206782 |
David Miller | 203 | 2573 | 204840 |
Rob Knight | 201 | 1061 | 253207 |
Mark I. McCarthy | 200 | 1028 | 187898 |
Michael Rutter | 188 | 676 | 151592 |
Eric Boerwinkle | 183 | 1321 | 170971 |
Terrie E. Moffitt | 182 | 594 | 150609 |
Kenneth S. Kendler | 177 | 1327 | 142251 |
John Hardy | 177 | 1178 | 171694 |
Dorret I. Boomsma | 176 | 1507 | 136353 |
Barry Halliwell | 173 | 662 | 159518 |
Feng Zhang | 172 | 1278 | 181865 |
Simon Baron-Cohen | 172 | 773 | 118071 |
Phillip A. Sharp | 172 | 614 | 117126 |
Yang Yang | 171 | 2644 | 153049 |