National Chung Hsing University

About: National Chung Hsing University is a education organization based out in Taichung, Taiwan. It is known for research contribution in the topics: Catalysis & Thin film. The organization has 19443 authors who have published 24060 publications receiving 540154 citations. The organization is also known as: NCHU.

Anthocyanins induce the activation of phase II enzymes through the antioxidant response element pathway against oxidative stress-induced apoptosis.

Abstract: Reactive oxygen species (ROS)-induced cell damage is inevitable and severe and is involved in numerous diseases, including cancer. Reducing oxidative stress is one of the strategies of chemoprevention. Anthocyanins are naturally occurring flavonoids that show multiple benefits. We first pointed out the effects of anthocyanins in the contributions to activation of phase II antioxidant and detoxifying enzymes, chemopreventive potency, and involved transcriptional regulation. Our results obtained in rat liver Clone 9 cells showed that treatment of anthocyanins leads to positive effects on elevating the antioxidant capacity, including activated expression of glutathione-related enzymes (glutathione reductase, glutathione peroxidase, and glutathione S-transferase) and recruited GSH content. In addition, the activity of NAD(P)H: quinone oxidoreductase (NQO1) was also promoted under the treatment of anthocyanin. This influential functions as the defense system against programmed cell death induced by H2O2. The c...

Recent Updates of Chemically Modified Electrodes in Analytical Chemistry

Abstract: This review article updates recent developments in chemically modified electrodes (CMEs) towards analytical applications for the year of 2000–2002 with 179 references. The broad topics are subdivided into four main categories: i) physisorption/chemisorption, ii) covalently linked, iii) homogenous (uniform) multilayer and iv) heterogeneous (non-uniform) multilayer CMEs. The criteria for the preparation of CMEs in elecrocatalytic systems are clearly described in Section 1. Some of the encouraging results related to Au-nanoparticles for DNA detection and new ceramic carbon, carbon nanotubes, copper-plated screen-printed and Nafion/lead ruthenate pyrochlore CMEs for catalytic application were especially discussed in this review.

Inhibition of advanced glycation endproduct formation by foodstuffs.

Abstract: The Maillard reaction, which is generally termed nonenzymatic browning or glycation, has been implicated in accelerated aging and diabetic complications in vivo. Although the molecular basis of glycation-induced pathogenesis is not well understood, the following have been noted: (1) protein glycation leads to the formation and accumulation of toxic advanced glycation endproducts (AGEs); (2) AGEs can permanently alter the structure and function of body proteins; and (3) the interaction between AGE-modified proteins and AGE-specific receptors (RAGEs) on the cell surface induces the overproduction of reactive oxygen species (ROSs) and inflammatory mediators, which leads to cellular disorders in biological systems. To date, studies that have examined the contribution of protein glycation to disease-states have primarily focused on the deleterious effects and related mechanisms of these glycotoxins. However, it remains unknown whether phytochemicals exert protective effects against glycotoxin-induced damage. Thus, the development and investigation of AGE inhibitors, especially the natural anti-AGE agents without adverse effects, may provide a therapeutic approach for delaying and preventing premature aging and diabetic complications. In this review, we provide an outline of anti-glycation properties of foodstuffs and/or their active components, and discuss their mechanisms of action.