Institution
National Chung Hsing University
Education•Taichung, Taiwan•
About: National Chung Hsing University is a education organization based out in Taichung, Taiwan. It is known for research contribution in the topics: Catalysis & Thin film. The organization has 19443 authors who have published 24060 publications receiving 540154 citations. The organization is also known as: NCHU.
Topics: Catalysis, Thin film, Population, Apoptosis, Gene
Papers published on a yearly basis
Papers
More filters
••
TL;DR: The elucidation of functional networks coordinated by dsRBM folds will require information on the precise functional relationship between different dsRBMs and a clarification of the principles underlying ds RBM–protein recognition.
Abstract: The double-stranded RNA-binding motif (dsRBM) is an alphabetabetabetaalpha fold with a well-characterized function to bind structured RNA molecules. This motif is widely distributed in eukaryotic proteins, as well as in proteins from bacteria and viruses. dsRBM-containing proteins are involved in processes ranging from RNA editing to protein phosphorylation in translational control and contain a variable number of dsRBM domains. The structural work of the past five years has identified a common mode of RNA target recognition by dsRBMs and dissected this recognition into two functionally separated interaction modes. The first involves the recognition of specific moieties of the RNA A-form helix by two protein loops, while the second is based on the interaction between structural elements flanking the RNA duplex with the first helix of the dsRBM. The latter interaction can be tuned by other protein elements. Recent work has made clear that dsRBMs can also recognize non-RNA targets (proteins and DNA), and act in combination with other dsRBMs and non-dsRBM motifs to play a regulatory role in catalytic processes. The elucidation of functional networks coordinated by dsRBM folds will require information on the precise functional relationship between different dsRBMs and a clarification of the principles underlying dsRBM-protein recognition.
124 citations
••
TL;DR: The hypothesis that melatonin is able to protect mice against stroke is supported by activating MT2 melatonin receptors, which reduces oxidative/inflammatory stress and enhances endogenous neurogenesis by upregulating neurodevelopmental gene/protein expression.
124 citations
••
TL;DR: The data suggest that the neuroprotective mechanisms of DHA pretreatment are, in part, mediated by attenuating damaging mechanisms through reduction of cytotoxic factor production and by strengthening survival mechanisms through ERK-mediated and/or Bcl-2-mediated prosurvival cascade.
Abstract: Evidence suggests that inactivation of cell-damaging mechanisms and/or activation of cell-survival mechanisms may provide effective preventive or therapeutic interventions to reduce cerebral ischemia/reperfusion (I/R) injuries. Docosahexaenoic acid (DHA) is an essential polyunsaturated fatty acid in the central nervous system that has been shown to possess neuroprotective effects. We examined whether different preadministrative protocols of DHA have effects on brain injury after focal cerebral I/R and investigated the potential neuroactive mechanisms involved. Sprague–Dawley rats were intraperitoneally pretreated with DHA once 1 h or 3 days being subjected to focal cerebral I/R or daily for 6 weeks before being subjected to focal cerebral I/R. Reduction of brain infarction was found in all three DHA-pretreated groups. The beneficial effect of DHA on the treatment groups was accompanied by decreases in blood–brain barrier disruption, brain edema, malondialdehyde (MDA) production, inflammatory cell infiltration, interleukin-6 (IL-6) expression and caspase-3 activity. Elevation of antioxidative capacity, as evidenced by decreased MDA level and increased superoxide dismutase activity and glutathione level, was detected only in the chronic daily-administration group. The two single-administration groups showed increased phosphorylation of extracellular-signal-regulated kinase (ERK). Elevation of Bcl-2 expression was detected in the chronic daily-administration and 3-day-administration groups. In vitro study demonstrated that DHA attenuated IL-6 production from stimulated glial cells involving nuclear factor κB inactivation. Therefore, the data suggest that the neuroprotective mechanisms of DHA pretreatment are, in part, mediated by attenuating damaging mechanisms through reduction of cytotoxic factor production and by strengthening survival mechanisms through ERK-mediated and/or Bcl-2-mediated prosurvival cascade.
124 citations
••
TL;DR: In this paper, the authors used the data for per capita carbon dioxide (CO 2 ) emissions relative to the average per capita emissions for 21 countries in the organisation for economic co-operation and development (OECD) covering the period 1960-2000 to determine whether the stochastic convergence and β-convergence of CO 2 emissions are supported in countries with the same level of development.
123 citations
••
TL;DR: In this article, the isothermal isotopic exchange reaction of 18O2 with 16O of supported transition metal oxides with ZrO2 has been investigated with in situ laser Raman spectroscopy.
Abstract: The isothermal isotopic exchange reaction of 18O2 with 16O of CrO3, MoO3, Nb2O5, WO3, V2O5, and Re2O7 supported on ZrO2 has been investigated with in situ laser Raman spectroscopy. Isotopic exchange of the oxygen atoms of the supported transition metal oxides with 18O2 is difficult and requires several successive reduction−18O2 reoxidation cycles at relatively high temperatures. The Raman spectroscopy data reveal that all the supported transition metal oxides are present as a monooxo species on ZrO2. This finding is consistent with the shifts calculated from the isotopic ratios for a simple diatomic oscillator, with the corresponding infrared spectra of the same catalysts and with the vibrational frequencies of several monooxo reference compounds. On this basis, coordination models of the molecular structures are proposed for CrO3/ZrO2, MoO3/ZrO2, Nb2O5/ZrO2, WO3/ZrO2, V2O5/ZrO2, and Re2O7/ZrO2 catalysts under dehydrated conditions.
123 citations
Authors
Showing all 19519 results
Name | H-index | Papers | Citations |
---|---|---|---|
Barry Halliwell | 173 | 662 | 159518 |
Chi-Huey Wong | 129 | 1220 | 66349 |
Meilin Liu | 117 | 827 | 52603 |
Wen-Hsiung Li | 106 | 461 | 61181 |
Pan-Chyr Yang | 102 | 786 | 46731 |
David A. Case | 102 | 364 | 74066 |
Jo Shu Chang | 99 | 639 | 37487 |
Wilhelm Gruissem | 94 | 325 | 32048 |
Pi-Tai Chou | 90 | 614 | 30922 |
Liang Tong | 81 | 342 | 21752 |
Tim H M Huang | 80 | 318 | 19905 |
De-en Jiang | 80 | 338 | 20466 |
Gwo-Hshiung Tzeng | 77 | 465 | 26807 |
Jianhua Yang | 74 | 554 | 27839 |
Gow-Chin Yen | 72 | 242 | 17303 |