National Chung Hsing University

About: National Chung Hsing University is a education organization based out in Taichung, Taiwan. It is known for research contribution in the topics: Catalysis & Thin film. The organization has 19443 authors who have published 24060 publications receiving 540154 citations. The organization is also known as: NCHU.

DiseaseConnect: a comprehensive web server for mechanism-based disease–disease connections

Abstract: The DiseaseConnect (http://disease-connect.org )i s a web server for analysis and visualization of a comprehensive knowledge on mechanism-based disease connectivity. The traditional disease classification system groups diseases with similar clinical symptoms and phenotypic traits. Thus, diseases with entirely different pathologies could be grouped together, leading to a similar treatment design. Such problems could be avoided if diseases were classified based on their molecular mechanisms. Connecting diseases with similar pathological mechanisms could inspire novel strategies on the effective repositioning of existing drugs and therapies. Although there have been several studies attempting to generate disease connectivity networks, they have not yet utilized the enormous and rapidly growing public repositories of disease-related omics data and literature, two primary resources capable of providing insights into disease connections at an unprecedented level of detail. Our DiseaseConnect, the first public web server, integrates comprehensive omics and literature data, including a large amount of gene expression data, Genome-Wide Association Studies catalog, and text-mined knowledge, to discover disease–disease connectivity via common molecular mechanisms. Moreover, the clinical comorbidity data and a comprehensive compilation of known drug– disease relationships are additionally utilized for advancing the understanding of the disease landscape and for facilitating the mechanism-based development of new drug treatments.

A study of vehicle routing problems with load‐balancing

Abstract: In a modern business environment, employees are a key resource to a company. Hence, the competitiveness of a company depends largely on its ability to treat employees fairly. Fairness can be attained by using the load‐balancing methodology. Develops an integer programming model for vehicle routing problems. There are two objectives, first, to minimize the total distance, and second, to balance the workload among employees as much as possible. We also develop a heuristic algorithm to solve the problems. The findings show that the proposed heuristic algorithm performs well to our 11 test cases.

A publicly verifiable copyright-proving scheme resistant to malicious attacks

Abstract: A wavelet-based copyright-proving scheme that does not require the original image for logo verification is proposed in this paper. The scheme is strong enough to resist malicious manipulations of an image including blurring, JPEG compression, noising, sharpening, scaling, rotation, cropping, scaling-cropping, and print-photocopy-scan attacks. The proposed scheme is also resistant to StirMark and unZign attacks and it is not only a robust method but also a lossless one. Experiments are conducted to show the robustness of this method. Moreover, cryptographic tools, such as digital signature and timestamp, are introduced to make copyright proving publicly verifiable.