Institution
Nuffield Orthopaedic Centre
Healthcare•Oxford, United Kingdom•
About: Nuffield Orthopaedic Centre is a healthcare organization based out in Oxford, United Kingdom. It is known for research contribution in the topics: Population & Arthroplasty. The organization has 2082 authors who have published 2920 publications receiving 145718 citations.
Papers published on a yearly basis
Papers
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TL;DR: The results suggest that subtle variations in the early part of the swing phase pattern are responsible for large differences in the impulse experienced at heelstrike; the usually reported gait variables mask these variations.
47 citations
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TL;DR: These results are consistent with the theory that PTH and TCT provoke changes in osteogenic cell activity by regulation of calcium transport across cellular and subcellular membranes.
Abstract: The effects of parathyroid hormone (PTH) and thyrocalcitonin (TCT) on the cell membrane potential and cell metabolic activity were measured in osteoclasts. Parathyroid hormone rapidly depolarized the cells and, over a longer period, increased the rate of RNA synthesis. Thyrocalcitonin polarized the cells and inhibited the effect of PTH on RNA synthesis. These results are consistent with the theory that PTH and TCT provoke changes in osteogenic cell activity by regulation of calcium transport across cellular and subcellular membranes. (Endocrinology 88: 1021, 1971)
47 citations
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University of British Columbia1, Rutgers University2, Simon Fraser University3, Alberta Children's Hospital4, University of Toronto5, Boston Children's Hospital6, Seattle Children's7, Nuffield Orthopaedic Centre8, Stanford University9, University of California, San Francisco10, Saint Petersburg State Pediatric Medical University11, Children's Memorial Hospital12, Dalhousie University13, University of Utah14, University of Florida15, Children's Medical Center of Dallas16, Janeway Children's Health and Rehabilitation Centre17, Mahidol University18
TL;DR: To characterize the early disease course in childhood‐onset antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV) and the 12‐month outcomes in children with AAV, a large number of cases are diagnosed with central giant cell granuloma.
Abstract: Objective
To characterize the early disease course in childhood-onset antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV) and the 12-month outcomes in children with AAV.
Methods
Eligible subjects were children entered into the Pediatric Vasculitis Initiative study who were diagnosed before their eighteenth birthday as having granulomatosis with polyangiitis (Wegener's), microscopic polyangiitis, eosinophilic granulomatosis with polyangiitis (Churg-Strauss), or ANCA-positive pauci-immune glomerulonephritis. The primary outcome measure was achievement of disease remission (Pediatric Vasculitis Activity Score [PVAS] of 0) at 12 months with a corticosteroid dosage of <0.2 mg/kg/day. Secondary outcome measures included the rates of inactive disease (PVAS of 0, with any corticosteroid dosage) and rates of improvement at postinduction (4–6 months after diagnosis) and at 12 months, presence of damage at 12 months (measured by a modified Pediatric Vasculitis Damage Index [PVDI]; score 0 = no damage, score 1 = one damage item present), and relapse rates at 12 months.
Results
In total, 105 children with AAV were included in the study. The median age at diagnosis was 13.8 years (interquartile range 10.9–15.8 years). Among the study cohort, 42% of patients achieved remission at 12 months, 49% had inactive disease at postinduction (4–6 months), and 61% had inactive disease at 12 months. The majority of patients improved, even if they did not achieve inactive disease. An improvement in the PVAS score of at least 50% from time of diagnosis to postinduction was seen in 92% of patients. Minor relapses occurred in 12 (24%) of 51 patients after inactive disease had been achieved postinduction. The median PVDI damage score at 12 months was 1 (range 0–6), and 63% of patients had ≥1 PVDI damage item scored as present at 12 months.
Conclusion
This is the largest study to date to assess disease outcomes in pediatric AAV. Although the study showed that a significant proportion of patients did not achieve remission, the majority of patients responded to treatment. Unfortunately, more than one-half of this patient cohort experienced damage to various organ systems early in their disease course.
47 citations
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TL;DR: Long-term oral antibiotic regimes after insertion of internal fixation devices in the face of infection and eventual removal of these implants are recommended and microbiological re-sampling is recommended.
Abstract: ¶Background. We describe the management of osteomyelitis of the cervical spine, utilizing internal fixation with subsequent removal and culture of the implants. Four out of five patients had evidence of bacterial colonisation in close proximity to the internal fixation device.
47 citations
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TL;DR: Important deficiencies in NF2 diagnostic criteria are confirmed and the term “glioma” should be dropped and replaced by “ependymoma,” Similarly “neurofibroma’ should be removed.
46 citations
Authors
Showing all 2120 results
Name | H-index | Papers | Citations |
---|---|---|---|
Douglas G. Altman | 253 | 1001 | 680344 |
George Davey Smith | 224 | 2540 | 248373 |
Cyrus Cooper | 204 | 1869 | 206782 |
James J. Collins | 151 | 669 | 89476 |
Richard J.H. Smith | 118 | 1308 | 61779 |
Andrew Carr | 111 | 842 | 54974 |
Paul Dieppe | 105 | 618 | 53529 |
Matthew A. Brown | 103 | 748 | 59727 |
David W. Murray | 97 | 699 | 43372 |
Ray Fitzpatrick | 95 | 477 | 40322 |
Derrick W. Crook | 92 | 474 | 29885 |
Richard W Morris | 91 | 519 | 35165 |
Richard J. K. Taylor | 91 | 1543 | 43893 |
Sharon J. Peacock | 90 | 494 | 33352 |
Derick T Wade | 90 | 398 | 37413 |