S
Shufeng Chen
Researcher at Peking Union Medical College
Publications - 105
Citations - 5776
Shufeng Chen is an academic researcher from Peking Union Medical College. The author has contributed to research in topics: Single-nucleotide polymorphism & Medicine. The author has an hindex of 25, co-authored 86 publications receiving 4433 citations. Previous affiliations of Shufeng Chen include Nanjing Medical University.
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Journal ArticleDOI
A comprehensive 1000 Genomes–based genome-wide association meta-analysis of coronary artery disease
Majid Nikpay,Anuj Goel,Won H-H.,Leanne M. Hall,Christina Willenborg,Stavroula Kanoni,Danish Saleheen,Theodosios Kyriakou,Christopher P. Nelson,Christopher P. Nelson,Jemma C. Hopewell,Tom R. Webb,Tom R. Webb,Lingyao Zeng,Abbas Dehghan,Maris Alver,Sebastian M. Armasu,Kirsi Auro,Kirsi Auro,Andrew Bjonnes,Daniel I. Chasman,Shufeng Chen,Ian Ford,Nora Franceschini,Christian Gieger,Christopher Grace,Stefan Gustafsson,Jie Huang,Hwang S-J.,Yun Kyoung Kim,Marcus E. Kleber,King Wai Lau,Xiangfeng Lu,Yingchang Lu,Lyytikäinen L-P.,Evelin Mihailov,Alanna C. Morrison,Natalia Pervjakova,Natalia Pervjakova,Natalia Pervjakova,Liming Qu,Lynda M. Rose,Elias Salfati,Richa Saxena,Markus Scholz,Albert V. Smith,Emmi Tikkanen,André G. Uitterlinden,Xueli Yang,Weihua Zhang,Wei Zhao,M. De Andrade,P. De Vries,N. R. van Zuydam,N. R. van Zuydam,Sonia S. Anand,Lars Bertram,Frank Beutner,George Dedoussis,Philippe M. Frossard,Dominique Gauguier,Alison H. Goodall,Omri Gottesman,Marc Haber,Han B-G.,Shapour Jalilzadeh,Thorsten Kessler,Inke R. König,Lars Lannfelt,Wolfgang Lieb,Lars Lind,Cecilia M. Lindgren,Lokki M-L.,Lokki M-L.,Patrik K. E. Magnusson,Nadeem Hayyat Mallick,Narinder K. Mehra,Thomas Meitinger,Memon F-U-R.,Andrew P. Morris,Andrew P. Morris,Markku S. Nieminen,Nancy L. Pedersen,Annette Peters,Loukianos S. Rallidis,Adil Rasheed,M Samuel,Svati H. Shah,Juha Sinisalo,Kathleen Stirrups,Stella Trompet,Ligui Wang,Ligui Wang,Khan Shah Zaman,Diego Ardissino,Eric Boerwinkle,Ingrid B. Borecki,Erwin P. Bottinger,Julie E. Buring,John C. Chambers,Rory Collins,L. A. Cupples,L. A. Cupples,John Danesh,Ilja Demuth,Roberto Elosua,Stephen E. Epstein,Tõnu Esko,Mary F. Feitosa,Oscar H. Franco,MariaGrazia Franzosi,Christopher B. Granger,Dongfeng Gu,Vilmundur Gudnason,Alistair S. Hall,Anders Hamsten,Tamara B. Harris,Stanley L. Hazen,Christian Hengstenberg,Albert Hofman,Erik Ingelsson,Carlos Iribarren,J W Jukema,Pekka J. Karhunen,Kim B-J.,Jaspal S. Kooner,Iftikhar J. Kullo,Terho Lehtimäki,Loos Rjf.,Olle Melander,Andres Metspalu,Winfried März,Winfried März,Winfried März,Colin N. A. Palmer,Markus Perola,Markus Perola,Markus Perola,Thomas Quertermous,Daniel J. Rader,Paul M. Ridker,Samuli Ripatti,Samuli Ripatti,Robert Roberts,Veikko Salomaa,Dharambir K. Sanghera,Stephen M. Schwartz,Udo Seedorf,Alexandre F.R. Stewart,David J. Stott,Joachim Thiery,Pierre Zalloua,Christopher J. O'Donnell,Christopher J. O'Donnell,Muredach P. Reilly,Themistocles L. Assimes,John R. Thompson,Jeanette Erdmann,Robert Clarke,Hugh Watkins,Sekar Kathiresan,Ruth McPherson,Panos Deloukas,Panos Deloukas,Heribert Schunkert,Nilesh J. Samani,Nilesh J. Samani,Martin Farrall +167 more
TL;DR: This article conducted a meta-analysis of coronary artery disease (CAD) cases and controls, interrogating 6.7 million common (minor allele frequency (MAF) > 0.05) and 2.7 millions low-frequency (0.005 < MAF < 0.5) variants.
A comprehensive 1000 Genomes-based genome-wide association meta-analysis of coronary artery disease
Majid Nikpay,Anuj Goel,Hong-Hee Won,Leanne M. Hall,Christina Willenborg,Stavroula Kanoni,Danish Saleheen,Theodosios Kyriakou,Christopher P. Nelson,Jemma C. Hopewell,Tom R. Webb,Lingyao Zeng,Abbas Dehghan,Maris Alver,Sebastian M. Armasu,Kirsi Auro,Andrew Bjonnes,Daniel I. Chasman,Shufeng Chen,Ian Ford,Nora Franceschini,Christian Gieger,Christopher Grace,Stefan Gustafsson,Jie Huang,Shih-Jen Hwang,Yun Kyoung Kim,Marcus E. Kleber,King Wai Lau,Xiangfeng Lu,Yingchang Lu,Leo-Pekka Lyytikäinen,Evelin Mihailov,Alanna C. Morrison,Natalia Pervjakova,Liming Qu,Lynda M. Rose,Elias Salfati,Richa Saxena,Markus Scholz,Albert V. Smith,Emmi Tikkanen,André G. Uitterlinden,Xueli Yang,Weihua Zhang,Wei Zhao,Mariza de Andrade,Paul S. de Vries,Natalie R. van Zuydam,Sonia S. Anand,Lars Bertram,Frank Beutner,George Dedoussis,Philippe M. Frossard,Dominique Gauguier,Alison H. Goodall,Omri Gottesman,Marc Haber,Bok-Ghee Han,Jianfeng Huang,Shapour Jalilzadeh,Thorsten Kessler,Inke R. Koenig,Lars Lannfelt,Wolfgang Lieb,Lars Lind,Cecilia M. Lindgren,Marja-Liisa Lokki,Patrik K. E. Magnusson,Nadeem Hayat Mallick,Narinder K. Mehra,Thomas Meitinger,Fazal-ur-Rehman Memon,Andrew P. Morris,Markku S. Nieminen,Nancy L. Pedersen,Annette Peters,Loukianos S. Rallidis,Asif Rasheed,Maria Samuel,Svati H. Shah,Juha Sinisalo,Kathleen Stirrups,Stella Trompet,Laiyuan Wang,Khan Shah Zaman,Diego Ardissino,Eric Boerwinkle,Ingrid B. Borecki,Erwin P. Bottinger,Julie E. Buring,John C. Chambers,Rory Collins,L. Adrienne Cupples,John Danesh,Ilja Demuth,Roberto Elosua,Stephen E. Epstein,Tõnu Esko,Mary F. Feitosa,Oscar H. Franco,Maria Grazia Franzosi,Christopher B. Granger,Dongfeng Gu,Vilmundur Gudnason,Alistair S. Hall,Anders Hamsten,Tamara B. Harris,Stanley L. Hazen,Christian Hengstenberg,Albert Hofman,Erik Ingelsson,Carlos Iribarren,J. Wouter Jukema,Pekka J. Karhunen,Bong-Jo Kim,Jaspal S. Kooner,Iftikhar J. Kullo,Terho Lehtimäki,Ruth J. F. Loos,Olle Melander,Andres Metspalu,Winfried Maerz,Colin N. A. Palmer,Markus Perola,Thomas Quertermous,Daniel J. Rader,Paul M. Ridker,Samuli Ripatti,Robert Roberts,Veikko Salomaa,Dharambir K. Sanghera,Stephen M. Schwartz,Udo Seedorf,Alexandre F.R. Stewart,David J. Stott,Joachim Thiery,Pierre Zalloua,Christopher J. O'Donnell,Muredach P. Reilly,Themistocles L. Assimes,John R. Thompson,Jeanette Erdmann,Robert Clarke,Hugh Watkins,Sekar Kathiresan,Ruth McPherson,Panos Deloukas,Heribert Schunkert,Nilesh J. Samani,Martin Farrall +150 more
TL;DR: A GWAS meta-analysis of CAD cases and controls provides a comprehensive survey of the fine genetic architecture of CAD, showing that genetic susceptibility to this common disease is largely determined by common SNPs of small effect size.
Journal ArticleDOI
Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function
Cristian Pattaro,Alexander Teumer,Mathias Gorski,Audrey Y. Chu,Man Li,Vladan Mijatovic,Maija K. Garnaas,Adrienne Tin,Rossella Sorice,Yong Li,Daniel Taliun,Matthias Olden,Meredith C. Foster,Qiong Yang,Ming-Huei Chen,Tune H. Pers,Tune H. Pers,Andrew D. Johnson,Yi-An Ko,Christian Fuchsberger,Bamidele O. Tayo,Mike A. Nalls,Mary F. Feitosa,Aaron Isaacs,Abbas Dehghan,Pio D'Adamo,Adebowale Adeyemo,Aida Karina Dieffenbach,Alan B. Zonderman,Ilja M. Nolte,Peter J. van der Most,Alan F. Wright,Alan R. Shuldiner,Alan R. Shuldiner,Alanna C. Morrison,Albert Hofman,Albert V. Smith,Albert W. Dreisbach,Andre Franke,André G. Uitterlinden,Andres Metspalu,Anke Tönjes,Antonio Lupo,Antonietta Robino,Åsa Johansson,Ayse Demirkan,Barbara Kollerits,Barry I. Freedman,Belen Ponte,Ben A. Oostra,Bernhard Paulweber,Bernhard K. Krämer,Braxton D. Mitchell,Braxton D. Mitchell,Brendan M. Buckley,Carmen A. Peralta,Caroline Hayward,Catherine Helmer,Catherine Helmer,Charles N. Rotimi,Christian M. Shaffer,Christian Müller,Cinzia Sala,Cornelia M. van Duijn,Aude Saint-Pierre,Daniel Ackermann,Daniel Shriner,Daniela Ruggiero,Daniela Toniolo,Yingchang Lu,Daniele Cusi,Darina Czamara,David Ellinghaus,David S. Siscovick,Douglas M. Ruderfer,Christian Gieger,Harald Grallert,Elena Rochtchina,Elizabeth J. Atkinson,Elizabeth G. Holliday,Eric Boerwinkle,Erika Salvi,Erwin P. Bottinger,Federico Murgia,Fernando Rivadeneira,Florian Ernst,Florian Kronenberg,Frank B. Hu,Gerjan Navis,Gary C. Curhan,G. Ehret,Georg Homuth,Stefan Coassin,Gian Andri Thun,Gian Andri Thun,Giorgio Pistis,Giovanni Gambaro,Giovanni Malerba,Grant W. Montgomery,Gudny Eiriksdottir,Gunnar Jacobs,Guo Li,H.-Erich Wichmann,Harry Campbell,Helena Schmidt,Henri Wallaschofski,Henry Völzke,Hermann Brenner,Heyo K. Kroemer,Holly Kramer,Honghuang Lin,I. Mateo Leach,Ian Ford,Idris Guessous,Idris Guessous,Idris Guessous,Igor Rudan,Inga Prokopenko,Ingrid B. Borecki,Iris M. Heid,Ivana Kolcic,Ivana Persico,J. Wouter Jukema,James F. Wilson,Janine F. Felix,Jasmin Divers,Jean-Charles Lambert,Jeanette M. Stafford,Jean-Michel Gaspoz,Jennifer A. Smith,Jessica D. Faul,Jie Jin Wang,Jingzhong Ding,Joel N. Hirschhorn,Joel N. Hirschhorn,John Attia,John Attia,John Whitfield,John Chalmers,J. Viikari,Josef Coresh,Joshua C. Denny,Juha Karjalainen,Jyotika K. Fernandes,Karlhans Endlich,Katja Butterbach,Keith L. Keene,Kurt Lohman,Laura Portas,Lenore J. Launer,Leo-Pekka Lyytikäinen,Loic Yengo,Loic Yengo,Loic Yengo,Lude Franke,Luigi Ferrucci,Lynda M. Rose,Lyudmyla Kedenko,Madhumathi Rao,Maksim Struchalin,Marcus E. Kleber,Margherita Cavalieri,Margot Haun,Marilyn C. Cornelis,Marina Ciullo,Mario Pirastu,Mariza de Andrade,Mark McEvoy,Mark Woodward,Martin Adam,Martin Adam,Massimiliano Cocca,Matthias Nauck,Medea Imboden,Medea Imboden,Melanie Waldenberger,Menno Pruijm,Marie Metzger,Michael Stumvoll,Michele K. Evans,Michèle M. Sale,Mika Kähönen,Mladen Boban,Murielle Bochud,Myriam Rheinberger,Niek Verweij,Nabila Bouatia-Naji,Nabila Bouatia-Naji,Nicholas G. Martin,Nicholas G. Martin,Nicholas D. Hastie,Nicole Probst-Hensch,Nicole Probst-Hensch,Nicole Soranzo,Olivier Devuyst,Olli T. Raitakari,Omri Gottesman,Oscar H. Franco,Ozren Polasek,Paolo Gasparini,Patricia B. Munroe,Paul M. Ridker,Paul Mitchell,Paul Muntner,Christa Meisinger,Johannes H. Smit,Gonçalo R. Abecasis,Linda S. Adair,Myriam Alexander,David Altshuler,Najaf Amin,Dan E. Arking,Pankaj Arora,Yurii S. Aulchenko,Stephan J. L. Bakker,Stefania Bandinelli,Inês Barroso,Jacques S. Beckmann,John Beilby,Richard N. Bergman,Sven Bergmann,Joshua C. Bis,Michael Boehnke,Lori L. Bonnycastle,Stefan R. Bornstein,Michiel L. Bots,Jennifer L. Bragg-Gresham,Stefan Martin Brand,Eva Brand,Peter S. Braund,Morris J. Brown,Paul Burton,Juan P. Casas,Mark J. Caulfield,Aravinda Chakravarti,John C. Chambers,Giriraj R. Chandak,Yen Pei C. Chang,Fadi J. Charchar,Nish Chaturvedi,Yoon Shin Cho,Robert Clarke,Francis S. Collins,Rory Collins,John M. C. Connell,Jackie A. Cooper,Mark E. Cooper,Richard S. Cooper,Anna Maria Corsi,Marcus Dörr,Santosh Dahgam,John Danesh,George Davey Smith,Ian N. M. Day,Panos Deloukas,Matthew Denniff,Anna F. Dominiczak,Yanbin Dong,Ayo P. Doumatey,Paul Elliott,Roberto Elosua,Jeanette Erdmann,Susana Eyheramendy,Martin Farrall,Cristiano Fava,Terrence Forrester,F. Gerald R. Fowkes,Ervin R. Fox,Timothy M. Frayling,Pilar Galan,Santhi K. Ganesh,Melissa Garcia,Tom R. Gaunt,Nicole L. Glazer,Min Jin Go,Anuj Goel,Jürgen Grässler,Diederick E. Grobbee,Leif Groop,Simonetta Guarrera,Xiuqing Guo,David Hadley,Anders Hamsten,Bok Ghee Han,Rebecca Hardy,Anna-Liisa Hartikainen,Simon Heath,Susan R. Heckbert,Bo Hedblad,Serge Hercberg,Dena G. Hernandez,Andrew A. Hicks,Gina Hilton,Aroon D. Hingorani,Judith A. Hoffman Bolton,Jemma C. Hopewell,Philip Howard,Steve E. Humphries,Steven C. Hunt,Kristian Hveem,M. Arfan Ikram,Muhammad Islam,Naoharu Iwai,Marjo-Riitta Järvelin,Anne U. Jackson,Tazeen H. Jafar,C. S. Janipalli,Toby Johnson,Sekar Kathiresan,Kay-Tee Khaw,Hyung Lae Kim,Sanjay Kinra,Yoshikuni Kita,Mika Kivimäki,Jaspal S. Kooner,M. J.Kranthi Kumar,Diana Kuh,Smita R. Kulkarni,Meena Kumari,Johanna Kuusisto,Tatiana Kuznetsova,Markku Laakso,Maris Laan,Jaana Laitinen,Edward G. Lakatta,Carl D. Langefeld,Martin G. Larson,Mark Lathrop,Debbie A Lawlor,Robert W. Lawrence,Jong-Young Lee,Nanette R. Lee,Daniel Levy,Yali Li,Will Longstreth,Jian'an Luan,Gavin Lucas,Barbara Ludwig,Massimo Mangino,K. Radha Mani,Michael Marmot,Francesco U.S. Mattace-Raso,Giuseppe Matullo,Wendy L. McArdle,Colin A. McKenzie,Thomas Meitinger,Olle Melander,Pierre Meneton,James F. Meschia,Tetsuro Miki,Yuri Milaneschi,Karen L. Mohlke,Vincent Mooser,Mario A. Morken,Richard W Morris,Thomas H. Mosley,Samer S. Najjar,Narisu Narisu,Christopher Newton-Cheh,Khanh-Dung H. Nguyen,Peter M. Nilsson,Fredrik Nyberg,Christopher J. O'Donnell,Toshio Ogihara,Takayoshi Ohkubo,Tomonori Okamura,Rick Twee-Hee Ong,Halit Ongen,N. Charlotte Onland-Moret,Paul F. O'Reilly,Elin Org,Marco Orrù,Walter Palmas,Jutta Palmen,Lyle J. Palmer,Nicholette D. Palmer,Alex Parker,John F. Peden,Leena Peltonen,Markus Perola,Vasyl Pihur,Carl G. P. Platou,Andrew S. Plump,Dorairajan Prabhakaran,Bruce M. Psaty,Leslie J. Raffel,Dabeeru C. Rao,Asif Rasheed,Fulvio Ricceri,Kenneth Rice,Annika Rosengren,Jerome I. Rotter,Megan E. Rudock,Siim Sõber,Tunde Salako,Danish Saleheen,Veikko Salomaa,Nilesh J. Samani,Steven M. Schwartz,Peter Schwarz,Laura J. Scott,James Scott,Angelo Scuteri,Joban Sehmi,Mark Seielstad,Sudha Seshadri,Pankaj Sharma,Sue Shaw-Hawkins,Gang Shi,Nick Shrine,Eric J.G. Sijbrands,Xueling Sim,Andrew B. Singleton,Marketa Sjögren,Nicholas L. Smith,María Soler Artigas,Tim D. Spector,Jan A. Staessen,Alena Stančáková,Nanette I. Steinle,David P. Strachan,Heather M. Stringham,Yan V. Sun,Amy J. Swift,Yasuharu Tabara,E. Shyong Tai,Philippa J. Talmud,Andrew M. Taylor,Janoš Terzić,Dag S. Thelle,Martin D. Tobin,Maciej Tomaszewski,Vikal Tripathy,Jaakko Tuomilehto,Ioanna Tzoulaki,Manuela Uda,Hirotsugu Ueshima,Cuno S. P. M. Uiterwaal,Satoshi Umemura,Pim van der Harst,Yvonne T. van der Schouw,Wiek H. van Gilst,Erkki Vartiainen,Ramachandran S. Vasan,Gudrun Veldre,Germaine C. Verwoert,Margus Viigimaa,D. G. Vinay,Paolo Vineis,Benjamin F. Voight,Peter Vollenweider,Lynne E. Wagenknecht,Louise V. Wain,Xiaoling Wang,Thomas J. Wang,Nicholas J. Wareham,Hugh Watkins,Alan B. Weder,Peter H. Whincup,Kerri L. Wiggins,Jacqueline C.M. Witteman,Andrew Wong,Ying Wu,Chittaranjan S. Yajnik,Jie Yao,J. H. Young,Diana Zelenika,Guangju Zhai,Weihua Zhang,Feng Zhang,Jing Hua Zhao,Haidong Zhu,Xiaofeng Zhu,Paavo Zitting,Ewa Zukowska-Szczechowska,Yukinori Okada,Jer-Yuarn Wu,Jer-Yuarn Wu,Dongfeng Gu,Fumihiko Takeuchi,Atsushi Takahashi,Shiro Maeda,Tatsuhiko Tsunoda,Peng Chen,Su Chi Lim,Su Chi Lim,Tien Yin Wong,Tien Yin Wong,Tien Yin Wong,Jianjun Liu,Terri L. Young,Tin Aung,Tin Aung,Yik Ying Teo,Yik Ying Teo,Young-Jin Kim,Daehee Kang,Chien-Hsiun Chen,Chien-Hsiun Chen,Fuu Jen Tsai,Li Ching Chang,S. J.Cathy Fann,Hao Mei,James E. Hixson,Shufeng Chen,Tomohiro Katsuya,Masato Isono,Eva Albrecht,Kazuhiko Yamamoto,Michiaki Kubo,Yusuke Nakamura,Naoyuki Kamatani,Norihiro Kato,Jiang He,Yuan-Tsong Chen,Toshihiro Tanaka,Muredach P. Reilly,Heribert Schunkert,Heribert Schunkert,Themistocles L. Assimes,Alistair S. Hall,Christian Hengstenberg,Inke R. König,Reijo Laaksonen,Ruth McPherson,John R. Thompson,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Andreas Ziegler,Devin Absher,Li Chen,L. Adrienne Cupples,L. Adrienne Cupples,Eran Halperin,Eran Halperin,Mingyao Li,Kiran Musunuru,Kiran Musunuru,Michael Preuss,Arne Schillert,Gudmar Thorleifsson,George A. Wells,Hilma Holm,Robert Roberts,Alexandre F.R. Stewart,Stephen P. Fortmann,Alan S. Go,Mark A. Hlatky,Carlos Iribarren,Joshua W. Knowles,Richard M. Myers,Thomas Quertermous,S. Sidney,Neil Risch,Hua Tang,Stefan Blankenberg,Renate B. Schnabel,C. Sinning,Karl J. Lackner,Laurence Tiret,Viviane Nicaud,François Cambien,Christoph Bickel,Hans J. Rupprecht,Claire Perret,Carole Proust,Thomas Münzel,Maja Barbalić,Ida Yii Der Chen,Serkalem Demissie-Banjaw,Serkalem Demissie-Banjaw,Aaron R. Folsom,Thomas Lumley,Kristin D. Marciante,Kent D. Taylor,Kelly A. Volcik,Solveig Gretarsdottir,Jeffrey R. Gulcher,Augustine Kong,Kari Stefansson,Kari Stefansson,Gudmundur Thorgeirsson,Karl Andersen,Marcus Fischer,Anika Grosshennig,Patrick Linsel-Nitschke,Klaus Stark,Stefan Schreiber,Zouhair Aherrahrou,Petra Bruse,Angela Doering,Norman Klopp,Patrick Diemert,Christina Loley,Anja Medack,Janja Nahrstedt,Annette Peters,Arnika Kathleen Wagner,Christina Willenborg,Bernhard O. Böhm,Harald Dobnig,Tanja B. Grammer,Michael M. Hoffmann,Andreas Meinitzer,Bernhard R. Winkelmann,Stefan Pilz,Wilfried Renner,Hubert Scharnagl,Tatjana Stojakovic,Andreas Tomaschitz,Karl Winkler,Candace Guiducci,Noël P. Burtt,Stacey Gabriel,Sonny Dandona,Olga Jarinova,Liming Qu,Robert L. Wilensky,William H. Matthai,Hakon Hakonarson,Joe Devaney,Mary Susan Burnett,Augusto D. Pichard,Kenneth M. Kent,Lowell F. Satler,Joseph M. Lindsay,Ron Waksman,Christopher W. Knouff,Dawn M. Waterworth,M Walker,Stephen E. Epstein,Daniel J. Rader,Christopher P. Nelson,Benjamin J. Wright,Anthony J. Balmforth,Stephen G. Ball,Laura R. Loehr,Laura R. Loehr,Wayne D. Rosamond,Emelia J. Benjamin,Talin Haritunians,David Couper,Joanne M. Murabito,Ying A. Wang,Bruno H. Stricker,Patricia P. Chang,James T. Willerson,James T. Willerson,Stephan B. Felix,Norbert Watzinger,Jayashri Aragam,Robert Zweiker,Lars Lind,Richard J. Rodeheffer,Karin Halina Greiser,Jaap W. Deckers,Jan Stritzke,Erik Ingelsson,Iftikhar J. Kullo,Johannes Haerting,Thorsten Reffelmann,Margaret M. Redfield,Karl Werdan,Gary F. Mitchell,Donna K. Arnett,John S. Gottdiener,Maria Blettner,Nele Friedrich,Peter Kovacs,Philipp S. Wild,Philippe Froguel,Philippe Froguel,Philippe Froguel,Rainer Rettig,Reedik Mägi,Reiner Biffar,Reinhold Schmidt,Rita P.S. Middelberg,Robert J. Carroll,Brenda W.J.H. Penninx,Rodney J. Scott,Ronit Katz,Sanaz Sedaghat,Sarah H. Wild,Sharon L.R. Kardia,Sheila Ulivi,Shih-Jen Hwang,Stefan Enroth,Stefan Kloiber,Stella Trompet,Bénédicte Stengel,Stephen Hancock,Stephen Turner,Sylvia E. Rosas,Sylvia Stracke,Sylvia Stracke,Tamara B. Harris,Tanja Zeller,Tatijana Zemunik,Terho Lehtimäki,Thomas Illig,Thor Aspelund,Tiit Nikopensius,Tõnu Esko,Tõnu Esko,Toshiko Tanaka,Ulf Gyllensten,Uwe Völker,Valur Emilsson,Veronique Vitart,Ville Aalto,Vilmundur Gudnason,Vincent Chouraki,Wei-Min Chen,Wilmar Igl,Winfried März,Wolfgang Koenig,Wolfgang Lieb,Ruth J. F. Loos,Yongmei Liu,Harold Snieder,Peter P. Pramstaller,Afshin Parsa,Jeffrey R. O'Connell,Katalin Susztak,Pavel Hamet,Johanne Tremblay,Ian H. de Boer,Carsten A. Böger,Wolfram Goessling,Daniel I. Chasman,Anna Köttgen,Anna Köttgen,W. H. Linda Kao,Caroline S. Fox,Caroline S. Fox +735 more
TL;DR: A meta-analysis of genome-wide association studies for estimated glomerular filtration rate suggests that genetic determinants of eGFR are mediated largely through direct effects within the kidney and highlight important cell types and biological pathways.
Journal ArticleDOI
Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease
Xiangfeng Lu,Laiyuan Wang,Laiyuan Wang,Shufeng Chen,Lin He,Xueli Yang,Yongyong Shi,Jing Cheng,Lei Zhang,C. Charles Gu,Jianfeng Huang,Tangchun Wu,Yitong Ma,Jianxin Li,Jie Cao,Jichun Chen,Dongliang Ge,Zhongjie Fan,Ying Li,Liancheng Zhao,Hongfan Li,Xiaoyang Zhou,Lanying Chen,Donghua Liu,Jingping Chen,Xiufang Duan,Yongchen Hao,Ligui Wang,Fanghong Lu,Zhendong Liu,Cailiang Yao,Chong Shen,Xiaodong Pu,Lin Yu,Xianghua Fang,Lihua Xu,Jianjun Mu,Xian-Ping Wu,Runping Zheng,Naqiong Wu,Qi Zhao,Yun Li,Xiaoli Liu,Mengqin Wang,Dahai Yu,Dongsheng Hu,Dongsheng Hu,Xu Ji,Dongshuang Guo,Dongling Sun,Qianqian Wang,Ying Yang,Fangchao Liu,Qunxia Mao,Xiao-hua Liang,Jingfeng Ji,Panpan Chen,Xing-Bo Mo,Dianjiang Li,Guoping Chai,Yida Tang,Xiangdong Li,Zhenhan Du,Xuehui Liu,Chenlong Dou,Zili Yang,Qingjie Meng,Dong Wang,Renping Wang,Jun Yang,Heribert Schunkert,Nilesh J. Samani,Nilesh J. Samani,Sekar Kathiresan,Sekar Kathiresan,Muredach P. Reilly,Jeanette Erdmann,Xiaozhong Peng,Xigui Wu,De-Pei Liu,Yuejin Yang,Runsheng Chen,Boqin Qiang,Dongfeng Gu +83 more
TL;DR: A meta-analysis of 2 genome-wide association studies of coronary artery disease comprising 1,515 cases and 5,019 controls followed by replication studies in 15,460 cases and 11,472 controls provides new insights into pathways contributing to the susceptibility for coronary arteries disease in the Chinese Han population.
Journal ArticleDOI
Meta-analysis identifies multiple loci associated with kidney function–related traits in east Asian populations
Yukinori Okada,Xueling Sim,Xueling Sim,Min Jin Go,Jer-Yuarn Wu,Jer-Yuarn Wu,Dongfeng Gu,Fumihiko Takeuchi,Atsushi Takahashi,Shiro Maeda,Tatsuhiko Tsunoda,Peng Chen,Su Chi Lim,Su Chi Lim,Tien Yin Wong,Tien Yin Wong,Tien Yin Wong,Jianjun Liu,Terri L. Young,Tin Aung,Tin Aung,Mark Seielstad,Yik Ying Teo,Yik Ying Teo,Young-Jin Kim,Jong-Young Lee,Bok Ghee Han,Daehee Kang,Chien Hsiun Chen,Chien Hsiun Chen,Fuu Jen Tsai,Li-Ching Chang,S. J. Fann,Hao Mei,Dabeeru C. Rao,James E. Hixson,Shufeng Chen,Tomohiro Katsuya,Motohide Isono,Toshio Ogihara,Toshio Ogihara,John C. Chambers,Weihua Zhang,Jaspal S. Kooner,E Albrecht,Kazuhiko Yamamoto,Michiaki Kubo,Yusuke Nakamura,Kamatani Naoyuki,Norihiro Kato,Jiang He,Yuan-Tsong Chen,Yoon Shin Cho,E-Shyong Tai,Toshihiro Tanaka,Graham M. Lord,P. van der Harst,Debbie A Lawlor,Jobanpreet Sehmi,Daniel P. Gale,Mark N. Wass,Kourosh R. Ahmadi,Stephan J. L. Bakker,Jacqui Beckmann,Hjg Bilo,Murielle Bochud,Morris J. Brown,M. J. Caulfield,Jmc Connell,H.T. Cook,Ioana Cotlarciuc,George Davey Smith,R. de Silva,G. Deng,Olivier Devuyst,L. D. Dikkeschei,N. Dimkovic,M. Dockrell,Anna F. Dominiczak,S Ebrahim,Thomas Eggermann,Martin Farrall,L Ferrucci,Juergen Floege,Nita G. Forouhi,Ron T. Gansevoort,X. Han,Bo Hedblad,J. J. van der Heide,Bouke G. Hepkema,Maria P. Hernandez-Fuentes,Elina Hyppönen,Toby Johnson,P. E. De Jong,Nanno Kleefstra,Vasiliki Lagou,Marta Lapsley,Yun Li,Ruth J. F. Loos,Jian'an Luan,Karin Luttropp,Céline Maréchal,Olle Melander,Patricia B. Munroe,Louise Nordfors,Afshin Parsa,Leena Peltonen,B.W.J.H. Penninx,Esperanza Perucha,A Pouta,Inga Prokopenko,Paul Roderick,Aimo Ruokonen,Nilesh J. Samani,Serena Sanna,Martin Schalling,David Schlessinger,Georg Schlieper,Marc A. Seelen,A. R. Shuldiner,Marketa Sjögren,J.H. Smit,Harold Snieder,Nicola Soranzo,Tim D. Spector,Peter Stenvinkel,Michael J.E. Sternberg,R. Swaminathan,L.J. Ubink-Veltmaat,Manuela Uda,Peter Vollenweider,Chris Wallace,Dawn M. Waterworth,Klaus Zerres,Gérard Waeber,Nicholas J. Wareham,Patrick H. Maxwell,Mark I. McCarthy,M-R Jarvelin,Vincent Mooser,G. Abecasis,Liz Lightstone,Jemima Scott,Gerjan Navis,Paul Elliott,Anna Köttgen,C. Pattaro,Carsten A. Böger,Christian Fuchsberger,Matthias Olden,Nicole L. Glazer,X. Gao,Qiong Yang,Albert V. Smith,Jeffery R. O'Connell,Man Li,H. Schmidt,A Isaacs,Shamika Ketkar,Shih-Jen Hwang,Andrew D. Johnson,Abbas Dehghan,A. Teumer,Guillaume Paré,Elizabeth J. Atkinson,Tanja Zeller,Kurt Lohman,Marilyn C. Cornelis,Nicole Probst-Hensch,Florian Kronenberg,A Tönjes,Caroline Hayward,Thor Aspelund,G. Eiriksdottir,L. J. Launer,T.B. Harris,Evandine Rampersaud,B. D. Mitchell,D.E. Arking,Eric Boerwinkle,Maksim Struchalin,Margherita Cavalieri,AB Singleton,Francesco Giallauria,Jeffrey Metter,I. H. de Boer,Talin Haritunians,Thomas Lumley,David S. Siscovick,Bruce M. Psaty,M. C. Zillikens,B.A. Oostra,Mary F. Feitosa,M. A. Province,M. De Andrade,Stephen T. Turner,Arne Schillert,Anette-G. Ziegler,Philipp S. Wild,Renate B. Schnabel,Sandra Wilde,Thomas Münzel,Tennille S. Leak,Thomas Illig,N. Klopp,Christine Meisinger,Heinz Erich Wichmann,Wolfgang Koenig,Lina Zgaga,Tatijana Zemunik,Ivana Kolcic,Cosetta Minelli,Frank B. Hu,Johansson,Wilmar Igl,Ghazal Zaboli,Sarah H. Wild,A. F. Wright,Hannah Campbell,David Ellinghaus,Stuart L. Schreiber,Y S Aulchenko,Janine F. Felix,F. Rivadeneira,A.G. Uitterlinden,A. Hofman,Medea Imboden,Dorothea Nitsch,Anita Brandstätter,Barbara Kollerits,Lyudmyla Kedenko,Reedik Mägi,Michael Stumvoll,Peter Kovacs,Mladen Boban,Sharon Campbell,Karlhans Endlich,Henry Völzke,Heyo K. Kroemer,Matthias Nauck,Uwe Völker,Ozren Polašek,Veronique Vitart,Sunita Badola,Alex Parker,Paul M. Ridker,Sharon L.R. Kardia,Stefan Blankenberg,Yongmei Liu,G. C. Curhan,Andre Franke,Tatiana Rochat,B. Paulweber,W. Wang,Vilmundur Gudnason,Josef Coresh,Reinhold E. Schmidt,Michael G. Shlipak,C M van Duijn,Ingrid B. Borecki,Bernhard K. Krämer,Igor Rudan,Ulf Gyllensten,J.F. Wilson,J. C. M. Witteman,Peter P. Pramstaller,Rainer Rettig,Nicholas D. Hastie,Daniel I. Chasman,W. H. Kao,I. M. Heid,Caroline S. Fox,Jan Krumsiek,Claudia Hundertmark,Giorgio Pistis,Daniela Ruggiero,M. O'seaghdha,T. Haller,Z. Kutalik,Julia Shi,P. S. Middelberg,Angelo L. Gaffo,Nicola Pirastu,Guo Li,Jennifer E. Huffman,Loic Yengo,Jing Hua Zhao,Ayse Demirkan,M. F. Feitosa,Xuan Liu,Giovanni Malerba,Lorna M. Lopez,Xinzhong Li,Marcus E. Kleber,Andrew A. Hicks,Ilja M. Nolte,Åsa Johansson,Federico Murgia,J F Peden,Maristella Steri,Albert Tenesa,Perttu Salo,Massimo Mangino,Lynda M. Rose,Terho Lehtimäki,Owen M. Woodward,Adrienne Tin,Craig Muller,Christopher Oldmeadow,Margus Putku,Darina Czamara,Peter Kraft,Laura Frogheri,Gian Andri Thun,Anne Grotevendt,Gauti Kjartan Gislason,Patrick F. McArdle,Michael Schallert,N. G. Martin,Grant W. Montgomery,David R. Jacobs,Kiang Liu,Pio D'Adamo,S. Ulivi,Jerome I. Rotter,P. Navaro,B. Balkau,Philippe Froguel,Tõnu Esko,Andres Salumets,Kay-Tee Khaw,Claudia Langenberg,Aldi T. Kraja,Qunyuan Zhang,Rodney J. Scott,Elizabeth G. Holliday,Elin Org,Margus Viigimaa,Stefania Bandinelli,Jeffery Metter,Antonio Lupo,Elisabetta Trabetti,Rossella Sorice,Angela Döring,Eva Lattka,Konstantin Strauch,Fabian J. Theis,M. Waldenberger,G. Davies,Alan J. Gow,Marcel Bruinenberg,Ronald P. Stolk,Winkelmann Br,B O Boehm,Susanne Lucae,G. Curhan,Poorva Mudgal,Robert M. Plenge,Laura Portas,Ivana Persico,Mirna Kirin,I. Mateo Leach,W. H. Van Gilst,Anuj Goel,Halit Ongen,A. von Eckardstein,Francesco Cucca,Ramaiah Nagaraja,Maria Grazia Piras,Claudia Schurmann,Klemens Budde,Florian Ernst,Susan M. Farrington,Evropi Theodoratou,A. Jula,M. Perola,V. Salomaa,So-Youn Shin,Cinzia Sala,Mika Kähönen,Jorma Viikari,Christian Hengstenberg,Christopher P. Nelson,James F. Meschia,Michael A. Nalls,Pankaj Sharma,Andrew B. Singleton,Michel Burnier,John Attia,Maris Laan,Hans L. Hillege,Stefan Kloiber,Hyon K. Choi,Mario Pirastu,Silvia Tore,John Whitfield,Myriam Fornage,Paolo Gasparini,David S. Siscovick,Nabila Bouatia-Naji,Andres Metspalu,Ingrid B. Borecki,Giovanni Gambaro,Ian J. Deary,Bruce H. R. Wolffenbuttel,W. März,Hugh Watkins,Sabine Schipf,Malcolm G. Dunlop,S. Ripatti,Daniela Toniolo,Olli T. Raitakari,Marina Ciullo,Mark J. Caulfield,C Gieger +414 more
TL;DR: A meta-analysis of genome-wide association studies for kidney function–related traits, including 71,149 east Asian individuals from 18 studies in 11 population-, hospital- or family-based cohorts, conducted as part of the Asian Genetic Epidemiology Network (AGEN), identified 17 loci newly associated with kidney function-related traits.