Institution
Rappaport Faculty of Medicine
About: Rappaport Faculty of Medicine is a based out in . It is known for research contribution in the topics: Population & Heparanase. The organization has 3205 authors who have published 3915 publications receiving 114533 citations.
Topics: Population, Heparanase, Medicine, Cancer, Pregnancy
Papers published on a yearly basis
Papers
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TL;DR: The authors identified a genetic locus for autosomal-recessive nonsyndromic intellectual disability associated with variable postnatal microcephaly through homozygosity mapping of a consanguineous Israeli Arab family.
Abstract: Although autosomal genes are increasingly recognized as important causes of intellectual disability, very few of them are known. We identified a genetic locus for autosomal-recessive nonsyndromic intellectual disability associated with variable postnatal microcephaly through homozygosity mapping of a consanguineous Israeli Arab family. Sequence analysis of genes in the candidate interval identified a nonsense nucleotide change in the gene that encodes TRAPPC9 (trafficking protein particle complex 9, also known as NIBP), which has been implicated in NF-κB activation and possibly in intracellular protein trafficking. TRAPPC9 is highly expressed in the postmitotic neurons of the cerebral cortex, and MRI analysis of affected patients shows defects in axonal connectivity. This suggests essential roles of TRAPPC9 in human brain development, possibly through its effect on NF-κB activation and protein trafficking in the postmitotic neurons of the cerebral cortex.
140 citations
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Weizmann Institute of Science1, Technion – Israel Institute of Technology2, Netherlands Cancer Institute3, National Institutes of Health4, Wellcome Trust Sanger Institute5, Open University of Israel6, Hadassah Medical Center7, Rappaport Faculty of Medicine8, University of Texas MD Anderson Cancer Center9, Texas A&M University10, Hebrew University of Jerusalem11, University of Zurich12, Sheba Medical Center13, Tel Aviv University14, Canadian Institute for Advanced Research15, Discovery Institute16
TL;DR: In this article, the authors used 16S rRNA gene sequencing and HLA peptidomics to identify a peptide repertoire derived from intracellular bacteria that was presented on HLA-I/HLA-II molecules in melanoma tumours.
Abstract: A variety of species of bacteria are known to colonize human tumours1–11, proliferate within them and modulate immune function, which ultimately affects the survival of patients with cancer and their responses to treatment12–14. However, it is not known whether antigens derived from intracellular bacteria are presented by the human leukocyte antigen class I and II (HLA-I and HLA-II, respectively) molecules of tumour cells, or whether such antigens elicit a tumour-infiltrating T cell immune response. Here we used 16S rRNA gene sequencing and HLA peptidomics to identify a peptide repertoire derived from intracellular bacteria that was presented on HLA-I and HLA-II molecules in melanoma tumours. Our analysis of 17 melanoma metastases (derived from 9 patients) revealed 248 and 35 unique HLA-I and HLA-II peptides, respectively, that were derived from 41 species of bacteria. We identified recurrent bacterial peptides in tumours from different patients, as well as in different tumours from the same patient. Our study reveals that peptides derived from intracellular bacteria can be presented by tumour cells and elicit immune reactivity, and thus provides insight into a mechanism by which bacteria influence activation of the immune system and responses to therapy. HLA peptidomic analysis identifies recurrent intracellular bacteria-derived peptides presented on HLA-I and HLA-II molecules in melanoma tumours, revealing how bacteria can modulate immune functions and responses to cancer therapies.
137 citations
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TL;DR: Immunity of pregnant women with Tdap between 27-30(+6) weeks was associated with the highest umbilical cord GMCs of IgG to PT and FHA compared with immunization beyond 31 weeks gestation, and further research should be conducted to reaffirm these finding.
137 citations
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TL;DR: It is reported that miR-184 is silenced in the pancreatic islets of insulin-resistant mouse models and type 2 diabetic human subjects and administration of a ketogenic diet to ob/ob mice rescued insulin sensitivity and miR -184 expression and restored Ago2 and β cell mass.
137 citations
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TL;DR: Right prefrontal slow rTMS does not appear to have a beneficial effect for actively psychotic patients with schizophrenia, in contrast to previous positive findings in major depression.
137 citations
Authors
Showing all 3205 results
Name | H-index | Papers | Citations |
---|---|---|---|
Barry M. Brenner | 121 | 540 | 65006 |
Robert R. Edelman | 119 | 605 | 49475 |
David M. Goldenberg | 108 | 1238 | 48224 |
Moussa B.H. Youdim | 107 | 574 | 42538 |
Aaron Ciechanover | 105 | 315 | 58698 |
Israel Vlodavsky | 98 | 494 | 34150 |
Basil S. Lewis | 96 | 651 | 60124 |
Michael Aviram | 94 | 479 | 31141 |
Abraham Weizman | 81 | 1011 | 31083 |
Thomas N. Robinson | 81 | 309 | 26121 |
Peretz Lavie | 81 | 320 | 21532 |
Jacob M. Rowe | 75 | 328 | 20043 |
Hossam Haick | 72 | 279 | 15646 |
Walid Saliba | 70 | 359 | 19254 |
Gad Rennert | 67 | 350 | 17349 |