Institution
Rappaport Faculty of Medicine
About: Rappaport Faculty of Medicine is a based out in . It is known for research contribution in the topics: Population & Heparanase. The organization has 3205 authors who have published 3915 publications receiving 114533 citations.
Topics: Population, Heparanase, Medicine, Cancer, Pregnancy
Papers published on a yearly basis
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TL;DR: In an analysis of associations with CRC per standard deviation of PRS, the cumulative burden of CRC-associated common genetic variants to associate with early-onset cancer, and to be more strongly associated with early toonset than late-ONSet cancer-particularly in the absence of CRC family history is found.
79 citations
79 citations
TL;DR: The combination of antioxidants together with active paraoxonase decreases the formation of Ox-LDL and preserves PON1's ability to hydrolyze this atherogenic lipoprotein and hence, to attenuate atherosclerosis.
Abstract: Atherosclerosis is a multifactorial disease, where more than one mechanism, along more than one step, contributes to macrophage cholesterol accumulation and foam cell formation, the hallmar...
79 citations
International Agency for Research on Cancer1, Harvard University2, Brigham and Women's Hospital3, University Hospitals Bristol NHS Foundation Trust4, University of Bristol5, University of Ioannina6, Imperial College London7, Fred Hutchinson Cancer Research Center8, National Institutes of Health9, Cancer Epidemiology Unit10, University of Leeds11, German Cancer Research Center12, University of Melbourne13, Royal Melbourne Hospital14, Utrecht University15, Kaiser Permanente16, American Cancer Society17, University of Virginia18, University of Barcelona19, Ohio State University20, Cancer Council Victoria21, Cedars-Sinai Medical Center22, Lunenfeld-Tanenbaum Research Institute23, Monash University, Clayton campus24, University of Southern California25, Dresden University of Technology26, University of Washington27, University of North Carolina at Chapel Hill28, Chonnam National University29, University of Hawaii30, Karolinska University Hospital31, Karolinska Institutet32, University of León33, Memorial Sloan Kettering Cancer Center34, Cornell University35, Huntsman Cancer Institute36, Institut Gustave Roussy37, Paris Descartes University38, Université Paris-Saclay39, Johns Hopkins University40, Massey University41, Rappaport Faculty of Medicine42, University of Pittsburgh43, University of Utah44, Wageningen University and Research Centre45, Umeå University46, Academy of Sciences of the Czech Republic47, Charles University in Prague48, First Faculty of Medicine, Charles University in Prague49, Memorial University of Newfoundland50, Vanderbilt University51
TL;DR: In an analysis of blood samples from almost 400,000 participants in the UK Biobank, a higher level of IGF1, determined by genetic factors, was associated with colorectal cancer.
79 citations
TL;DR: It is suggested that rectal stump washout during anterior resection for carcinoma should be routine, and the volume of the lavage fluid should be larger than 500 ml.
Abstract: PURPOSE: It is possible that implantation of viable malignant cells is one of the mechanisms of anastomotic recurrence in rectosigmoid cancer. The viability of shed intraluminal cells was previously established and malignant cells were retrieved on circular staplers in unwashed rectal stumps. The aim of this study is to evaluate the effectiveness of a defined and uniform washout protocol in eradication of intraluminal malignant cells during anterior resection. METHODS: In 14 consecutive patients the closed rectal stump was washed before insertion of the circular stapler. The washout was performed uniformly by instillation of ten increments of 50 ml of saline through a rectal tube. Samples from the first, fifth, and tenth washings were collected for cytologic examination. The presence or absence of malignant cells was then correlated with rectal stump length, length of the tumor-free distal margin, and differentiation and Dukes staging of the tumor. RESULTS: In 11 patients the first washing was positive for free malignant cells, and the fifth washing was still positive in 7 patients; however, the last (tenth) samples were clear in 10 patients, and malignant cells were recovered in only 4 patients. The rectal stump and the tumor-free distal margin were shorter in patients who still had positive cytology for free intraluminal malignant cells after stump irrigation with 500 ml of saline. No correlation was found with tumor differentiation or staging. CONCLUSIONS: Free malignant cells are shed into the rectal stump during anterior resection. Mechanical lavage with saline effectively eradicates these cells; however, the completeness of cleansing is volume related. Incomplete cleansing with 500 ml of saline correlates with lower tumors. Technically more difficult surgery involves traumatic handling of the tumor and possibly induces shedding of more malignant cells. We suggest that rectal stump washout during anterior resection for carcinoma should be routine, and the volume of the lavage fluid should be larger than 500 ml.
79 citations
Authors
Showing all 3205 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Barry M. Brenner | 121 | 540 | 65006 |
| Robert R. Edelman | 119 | 605 | 49475 |
| David M. Goldenberg | 108 | 1238 | 48224 |
| Moussa B.H. Youdim | 107 | 574 | 42538 |
| Aaron Ciechanover | 105 | 315 | 58698 |
| Israel Vlodavsky | 98 | 494 | 34150 |
| Basil S. Lewis | 96 | 651 | 60124 |
| Michael Aviram | 94 | 479 | 31141 |
| Abraham Weizman | 81 | 1011 | 31083 |
| Thomas N. Robinson | 81 | 309 | 26121 |
| Peretz Lavie | 81 | 320 | 21532 |
| Jacob M. Rowe | 75 | 328 | 20043 |
| Hossam Haick | 72 | 279 | 15646 |
| Walid Saliba | 70 | 359 | 19254 |
| Gad Rennert | 67 | 350 | 17349 |