University of Auckland

About: University of Auckland is a education organization based out in Auckland, New Zealand. It is known for research contribution in the topics: Population & Context (language use). The organization has 28049 authors who have published 77706 publications receiving 2689366 citations. The organization is also known as: The University of Auckland & Auckland University College.

Idarucizumab for Dabigatran Reversal — Full Cohort Analysis

Abstract: BackgroundIdarucizumab, a monoclonal antibody fragment, was developed to reverse the anticoagulant effect of dabigatran. MethodsWe performed a multicenter, prospective, open-label study to determine whether 5 g of intravenous idarucizumab would be able to reverse the anticoagulant effect of dabigatran in patients who had uncontrolled bleeding (group A) or were about to undergo an urgent procedure (group B). The primary end point was the maximum percentage reversal of the anticoagulant effect of dabigatran within 4 hours after the administration of idarucizumab, on the basis of the diluted thrombin time or ecarin clotting time. Secondary end points included the restoration of hemostasis and safety measures. ResultsA total of 503 patients were enrolled: 301 in group A, and 202 in group B. The median maximum percentage reversal of dabigatran was 100% (95% confidence interval, 100 to 100), on the basis of either the diluted thrombin time or the ecarin clotting time. In group A, 137 patients (45.5%) presented ...

Dynamic panel estimation and homogeneity testing under cross section dependence

Abstract: Now published as a Journal Article in The Econometrics Journal Volume 6 Issue 1 Page 217 - June 2003 doi:10.1111/1368-423X.00108

Estimating maximum likelihood phylogenies with PhyML.

Abstract: Our understanding of the origins, the functions and/or the structures of biological sequences strongly depends on our ability to decipher the mechanisms of molecular evolution. These complex processes can be described through the comparison of homologous sequences in a phylogenetic framework. Moreover, phylogenetic inference provides sound statistical tools to exhibit the main features of molecular evolution from the analysis of actual sequences. This chapter focuses on phylogenetic tree estimation under the maximum likelihood (ML) principle. Phylogenies inferred under this probabilistic criterion are usually reliable and important biological hypotheses can be tested through the comparison of different models. Estimating ML phylogenies is computationally demanding, and careful examination of the results is warranted. This chapter focuses on PhyML, a software that implements recent ML phylogenetic methods and algorithms. We illustrate the strengths and pitfalls of this program through the analysis of a real data set. PhyML v3.0 is available from http://atgc.lirmm.fr/phyml.

Current Issues in the Teaching of Grammar: An SLA Perspective

Abstract: The study of how learners acquire a second language (SLA) has helped to shape thinking about how to teach the grammar of a second language There remain, however, a number of controversial issues This paper considers eight key questions relating to grammar pedagogy in the light of findings from SLA As such, this article complements Celce-Murcia’s (1991) article on grammar teaching in the 25th anniversary issue of TESOL Quarterly, which considered the role of grammar in a communicative curriculum and drew predominantly on a linguistic theory of grammar These eight questions address whether grammar should be taught and if so what grammar, when, and how Although SLA does not afford definitive solutions to these questions, it serves the valuable purpose of problematising this aspect of language pedagogy This article concludes with a statement of my own beliefs about grammar teaching, grounded in my own understanding of SLA