Institution
University of Auckland
Education•Auckland, New Zealand•
About: University of Auckland is a education organization based out in Auckland, New Zealand. It is known for research contribution in the topics: Population & Context (language use). The organization has 28049 authors who have published 77706 publications receiving 2689366 citations. The organization is also known as: The University of Auckland & Auckland University College.
Topics: Population, Context (language use), Poison control, Health care, Randomized controlled trial
Papers published on a yearly basis
Papers
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German Center for Neurodegenerative Diseases1, Salk Institute for Biological Studies2, Paracelsus Private Medical University of Salzburg3, University of Pennsylvania4, University of Auckland5, King's College London6, University of Gothenburg7, Charité8, University of Zurich9, National Institutes of Health10, Princeton University11, Columbia University12, French Institute of Health and Medical Research13, University of Lausanne14, Fundación Instituto Leloir15, University of Wisconsin-Madison16, University of Amsterdam17, Karolinska Institutet18
TL;DR: It is argued that there is currently no reason to abandon the idea that adult-generated neurons make important functional contributions to neural plasticity and cognition across the human lifespan.
544 citations
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TL;DR: The increasing experimental data on placental drug transfer has enabled clinicians to make better informed decisions about which drugs significantly cross the placenta and develop dosage regimens that minimise fetal exposure to potentially toxic concentrations.
Abstract: The major function of the placenta is to transfer nutrients and oxygen from the mother to the foetus and to assist in the removal of waste products from the foetus to the mother. In addition, it plays an important role in the synthesis of hormones, peptides and steroids that are vital for a successful pregnancy. The placenta provides a link between the circulations of two distinct individuals but also acts as a barrier to protect the foetus from xenobiotics in the maternal blood. However, the impression that the placenta forms an impenetrable obstacle against most drugs is now widely regarded as false. It has been shown that that nearly all drugs that are administered during pregnancy will enter, to some degree, the circulation of the foetus via passive diffusion. In addition, some drugs are pumped across the placenta by various active transporters located on both the fetal and maternal side of the trophoblast layer. It is only in recent years that the impact of active transporters such as P-glycoprotein on the disposition of drugs has been demonstrated. Facilitated diffusion appears to be a minor transfer mechanism for some drugs, and pinocytosis and phagocytosis are considered too slow to have any significant effect on fetal drug concentrations. The extent to which drugs cross the placenta is also modulated by the actions of placental phase I and II drug-metabolising enzymes, which are present at levels that fluctuate throughout gestation. Cytochrome P450 (CYP) enzymes in particular have been well characterised in the placenta at the level of mRNA, protein, and enzyme activity. CYP1A1, 2E1, 3A4, 3A5, 3A7 and 4B1 have been detected in the term placenta. While much less is known about phase II enzymes in the placenta, some enzymes, in particular uridine diphosphate glucuronosyltransferases, have been detected and shown to have specific activity towards marker substrates, suggesting a significant role of this enzyme in placental drug detoxification. The increasing experimental data on placental drug transfer has enabled clinicians to make better informed decisions about which drugs significantly cross the placenta and develop dosage regimens that minimise fetal exposure to potentially toxic concentrations. Indeed, the foetus has now become the object of intended drug treatment. Extensive research on the placental transfer of drugs such as digoxin and zidovudine has assisted with the safe treatment of the foetus with these drugs in utero. Improved knowledge regarding transplacental drug transfer and metabolism will result in further expansion of pharmacological treatment of fetal conditions.
543 citations
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University of Cambridge1, Fauna & Flora International2, International Union for Conservation of Nature and Natural Resources3, University of Auckland4, Natural Environment Research Council5, University of California, Davis6, Royal Society for the Protection of Birds7, Cranfield University8, Natural Resources Wales9, Joint Nature Conservation Committee10, University of Essex11, Stockholm University12, Venezuelan Institute for Scientific Research13, The Nature Conservancy14, Wetlands International15, University of East Anglia16
TL;DR: The authors in this article presented the output of the fifth annual horizon-scanning exercise, which aims to identify topics that increasingly may affect conservation of biological diversity, but have yet to be widely considered.
Abstract: This paper presents the output of our fifth annual horizon-scanning exercise, which aims to identify topics that increasingly may affect conservation of biological diversity, but have yet to be widely considered. A team of professional horizon scanners, researchers, practitioners, and a journalist identified 15 topics which were identified via an iterative, Delphi-like process. The 15 topics include a carbon market induced financial crash, rapid geographic expansion of macroalgal cultivation, genetic control of invasive species, probiotic therapy for amphibians, and an emerging snake fungal disease.
543 citations
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TL;DR: Compared with ovarian conservation, bilateral oophorectomy at the time of hysterectomy for benign disease is associated with a decreased risk of breast and ovarian cancer but an increased risk of all-cause mortality, fatal and nonfatal coronary heart disease, and lung cancer.
543 citations
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Institut national de la recherche scientifique1, University of Sussex2, Swinburne University of Technology3, University of Auckland4, Centre national de la recherche scientifique5, Georgia Institute of Technology6, University of Brescia7, National Physical Laboratory8, Tsinghua University9, Purdue University10, University of Electronic Science and Technology of China11
TL;DR: In this paper, a review of optical frequency combs with a large spectrum is presented, where the frequency and the phase do not vary and are completely determined by the source physical parameters.
543 citations
Authors
Showing all 28484 results
Name | H-index | Papers | Citations |
---|---|---|---|
Walter C. Willett | 334 | 2399 | 413322 |
Meir J. Stampfer | 277 | 1414 | 283776 |
Frank E. Speizer | 193 | 636 | 135891 |
Bernard Rosner | 190 | 1162 | 147661 |
Eric Boerwinkle | 183 | 1321 | 170971 |
Rory Collins | 162 | 489 | 193407 |
Monique M.B. Breteler | 159 | 546 | 93762 |
Charles H. Hennekens | 150 | 424 | 117806 |
Rajesh Kumar | 149 | 4439 | 140830 |
Hugh A. Sampson | 147 | 816 | 76492 |
David P. Strachan | 143 | 472 | 105256 |
Jun Lu | 135 | 1526 | 99767 |
Peter Zoller | 134 | 734 | 76093 |
David H. Barlow | 133 | 786 | 72730 |
Henry T. Lynch | 133 | 925 | 86270 |