Showing papers by "University of Lisbon published in 2022"

Atmospheric blocking and weather extremes over the Euro-Atlantic sector – a review

Abstract: Abstract. The physical understanding and timely prediction of extreme weather events are of enormous importance to society due to their associated impacts. In this article, we highlight several types of weather extremes occurring in Europe in connection with a particular atmospheric flow pattern, known as atmospheric blocking. This flow pattern effectively blocks the prevailing westerly large-scale atmospheric flow, resulting in changing flow anomalies in the vicinity of the blocking system and persistent conditions in the immediate region of its occurrence. Blocking systems are long-lasting, quasi-stationary and self-sustaining systems that occur frequently over certain regions. Their presence and characteristics have an impact on the predictability of weather extremes and can thus be used as potential indicators. The phasing between the surface and the upper-level blocking anomalies is of major importance for the development of the extreme event. In summer, heat waves and droughts form below the blocking anticyclone primarily via large-scale subsidence that leads to cloud-free skies and, thus, persistent shortwave radiative warming of the ground. In winter, cold waves that occur during atmospheric blocking are normally observed downstream or south of these systems. Here, meridional advection of cold air masses from higher latitudes plays a decisive role. Depending on their location, blocking systems also may lead to a shift in the storm track, which influences the occurrence of wind and precipitation anomalies. Due to these multifaceted linkages, compound events are often observed in conjunction with blocking conditions. In addition to the aforementioned relations, the predictability of extreme events associated with blocking and links to climate change are assessed. Finally, current knowledge gaps and pertinent research perspectives for the future are discussed.

Challenges in the Development of Drug Delivery Systems Based on Small Extracellular Vesicles for Therapy of Brain Diseases

Abstract: Small extracellular vesicles (sEVs) have ∼30-200 nm diameter size and may act as carriers of different cargoes, depending on the cell of origin or on the physiological/pathological condition. As endogenous nanovesicles, sEVs are important in intercellular communication and have many of the desirable features of an ideal drug delivery system. sEVs are naturally biocompatible, with superior targeting capability, safety profile, nanometric size, and can be loaded with both lipophilic and hydrophilic agents. Because of their biochemical and physical properties, sEVs are considered a promising strategy over other delivery vehicles in the central nervous system (CNS) since they freely cross the blood-brain barrier and they can be directed to specific nerve cells, potentiating a more precise targeting of their cargo. In addition, sEVs remain stable in the peripheral circulation, making them attractive nanocarrier systems to promote neuroregeneration. This review focuses on the recent progress in methods for manufacturing, isolating, and engineering sEVs that can be used as a therapeutic strategy to overcome neurodegeneration associated with pathologies of the CNS, with particular emphasis on Alzheimer's, Parkinson's, and amyotrophic lateral sclerosis diseases, as well as on brain tumors.

Optimal Management of Asymptomatic Carotid Stenosis in 2021: The Jury is Still Out. An International, Multispecialty, Expert Review and Position Statement

Abstract: Objectives The recommendations of international guidelines for the management of asymptomatic carotid stenosis (ACS) often vary considerably and extend from a conservative approach with risk factor modification and best medical treatment (BMT) alone, to a more aggressive approach with a carotid intervention plus BMT. The aim of the current multispecialty position statement is to reconcile the conflicting views on the topic. Materials and methods A literature review was performed with a focus on data from recent studies. Results Several clinical and imaging high-risk features have been identified that are associated with an increased long-term ipsilateral ischemic stroke risk in patients with ACS. Such high-risk clinical/imaging features include intraplaque hemorrhage, impaired cerebrovascular reserve, carotid plaque echolucency/ulceration/ neovascularization, a lipid-rich necrotic core, a thin or ruptured fibrous cap, silent brain infarction, a contralateral transient ischemic attack/stroke episode, male patients Conclusions Although aggressive risk factor control and BMT should be implemented in all ACS patients, several high-risk features that may increase the risk of a future cerebrovascular event are now documented. Consequently, some guidelines recommend a prophylactic carotid intervention in high-risk patients to prevent future cerebrovascular events. Until the results of the much-anticipated randomized controlled trials emerge, the jury is still out regarding the optimal management of ACS patients.

Modular flavour symmetries and modulus stabilisation

Abstract: A bstract We study the problem of modulus stabilisation in the framework of the modular symmetry approach to the flavour problem. By analysing simple UV-motivated CP-invariant potentials for the modulus τ we find that a class of these potentials has (non-fine-tuned) CP-breaking minima in the vicinity of the point of $$ {\mathrm{\mathbb{Z}}}_3^{ST} $$ ℤ 3 ST residual symmetry, τ ≃ e 2 πi /3 . Stabilising the modulus at these novel minima breaks spontaneously the CP symmetry and can naturally explain the mass hierarchies of charged leptons and possibly of quarks.