Institution
University of London
Education•London, United Kingdom•
About: University of London is a education organization based out in London, United Kingdom. It is known for research contribution in the topics: Population & Public health. The organization has 44838 authors who have published 88086 publications receiving 4002499 citations. The organization is also known as: London University & Lond..
Topics: Population, Public health, Health care, Malaria, Health policy
Papers published on a yearly basis
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TL;DR: This tutorial review examines the copper(I)-catalysed 1,2,3-triazole forming reaction between azides and terminal alkynes, which has become the gold standard of click chemistry due to its reliability, specificity and biocompatibility.
Abstract: Click chemistry, the subject of this tutorial review, is a modular synthetic approach towards the assembly of new molecular entities. This powerful strategy relies mainly upon the construction of carbon–heteroatom bonds using spring-loaded reactants. Its growing number of applications are found in nearly all areas of modern chemistry from drug discovery to materials science. The copper(I)-catalysed 1,2,3-triazole forming reaction between azides and terminal alkynes has become the gold standard of click chemistry due to its reliability, specificity and biocompatibility.
2,009 citations
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TL;DR: The genome sequence of C. jejuni NCTC11168 is reported, finding short homopolymeric runs of nucleotides were commonly found in genes encoding the biosynthesis or modification of surface structures, or in closely linked genes of unknown function.
Abstract: Campylobacter jejuni, from the delta-epsilon group of proteobacteria, is a microaerophilic, Gram-negative, flagellate, spiral bacterium—properties it shares with the related gastric pathogen Helicobacter pylori. It is the leading cause of bacterial food-borne diarrhoeal disease throughout the world1. In addition, infection with C. jejuni is the most frequent antecedent to a form of neuromuscular paralysis known as Guillain–Barre syndrome2. Here we report the genome sequence of C. jejuni NCTC11168. C. jejuni has a circular chromosome of 1,641,481 base pairs (30.6% G+C) which is predicted to encode 1,654 proteins and 54 stable RNA species. The genome is unusual in that there are virtually no insertion sequences or phage-associated sequences and very few repeat sequences. One of the most striking findings in the genome was the presence of hypervariable sequences. These short homopolymeric runs of nucleotides were commonly found in genes encoding the biosynthesis or modification of surface structures, or in closely linked genes of unknown function. The apparently high rate of variation of these homopolymeric tracts may be important in the survival strategy of C. jejuni.
1,979 citations
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Royal Children's Hospital1, University of Melbourne2, Columbia University3, University of London4, World Health Organization5, American University of Beirut6, University of Oregon7, Public Health Foundation of India8, University College London9, Burnet Institute10, United Nations Population Fund11, University of Toronto12, Aga Khan University13, Obafemi Awolowo University14, Jawaharlal Nehru University15, UNICEF16, Kunming Medical University17
TL;DR: This Commission outlines the opportunities and challenges for investment in adolescent health and wellbeing at both country and global levels (panel 1).
1,976 citations
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TL;DR: It has been found that epithelization is retarded by the dry scab which normally covers a superficial wound, and if the formation of the scab is prevented, the rate of epithelized is markedly increased.
Abstract: WHERE there is a superficial wound in the skin, new epidermis covers the denuded area by migration from the hair follicles and sweat gland ducts within the wound and from the surface epidermis at the wound edges. It has been found that epithelization is retarded by the dry scab which normally covers a superficial wound, and if the formation of the scab is prevented, the rate of epithelization is markedly increased.
1,958 citations
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TL;DR: It is shown that the strain of agent from cattle affected by bovine spongiform encephalopathy (BSE) produces a characteristic pattern of disease in mice that is retained after experimental passage through a variety of intermediate species, providing strong evidence that the same agent strain is involved in both BSE and vCJD.
Abstract: There are many strains of the agents that cause transmissible spongiform encephalopathies (TSEs) or 'prion' diseases. These strains are distinguishable by their disease characteristics in experimentally infected animals, in particular the incubation periods and neuropathology they produce in panels of inbred mouse strains. We have shown that the strain of agent from cattle affected by bovine spongiform encephalopathy (BSE) produces a characteristic pattern of disease in mice that is retained after experimental passage through a variety of intermediate species. This BSE 'signature' has also been identified in transmissions to mice of TSEs of domestic cats and two exotic species of ruminant, providing the first direct evidence for the accidental spread of a TSE between species. Twenty cases of a clinically and pathologically atypical form of Creutzfeldt-Jakob disease (CJD), referred to as 'new variant' CJD (vCJD), have been recognized in unusually young people in the United Kingdom, and a further case has been reported in France. This has raised serious concerns that BSE may have spread to humans, putatively by dietary exposure. Here we report the interim results of transmissions of sporadic CJD and vCJD to mice. Our data provide strong evidence that the same agent strain is involved in both BSE and vCJD.
1,957 citations
Authors
Showing all 44949 results
Name | H-index | Papers | Citations |
---|---|---|---|
George Davey Smith | 224 | 2540 | 248373 |
Karl J. Friston | 217 | 1267 | 217169 |
Nicholas J. Wareham | 212 | 1657 | 204896 |
David Miller | 203 | 2573 | 204840 |
Raymond J. Dolan | 196 | 919 | 138540 |
Peter J. Barnes | 194 | 1530 | 166618 |
Michael Marmot | 193 | 1147 | 170338 |
Michael Rutter | 188 | 676 | 151592 |
Terrie E. Moffitt | 182 | 594 | 150609 |
Tony Hunter | 175 | 593 | 124726 |
Chris D. Frith | 173 | 524 | 130472 |
David Baker | 173 | 1226 | 109377 |
Barry Halliwell | 173 | 662 | 159518 |
Didier Raoult | 173 | 3267 | 153016 |
Feng Zhang | 172 | 1278 | 181865 |