University of Los Andes

About: University of Los Andes is a education organization based out in Bogotá, Colombia. It is known for research contribution in the topics: Population & Large Hadron Collider. The organization has 17616 authors who have published 25555 publications receiving 413463 citations.

Diagnóstico, manejo y tratamiento de la cardiopatía chagásica crónica en áreas donde la infección por Trypanosoma cruzi no es endémica

Abstract: La enfermedad de Chagas o tripanosomiasis americana es una parasitosis originaria del continente americano. En la naturaleza, Trypanosoma cruzi se transmite vectorialmente a traves de diversas especies de chinches triatominos. No obstante, se han descrito otros mecanismos de transmision no vectorial, como la transmision a traves de productos sanguineos o mediante el trasplante de organos infectados, y la transmision vertical. Actualmente, la enfermedad de Chagas afecta a unos 10-12 millones de personas en el mundo y el proceso de urbanizacion en America Latina y los movimientos migratorios desde los paises endemicos han posibilitado que la enfermedad de Chagas sea diagnosticada en zonas donde la infeccion no es endemica. Se considera que un 20-30% de las personas infectadas por T. cruzi desarrollaran a lo largo de su vida alteraciones cardiacas. Las caracteristicas diferenciales de la cardiopatia chagasica, el escaso conocimiento que se tiene de ella en nuestro medio y la elevada frecuencia de arritmias y muerte subita como primeras manifestaciones potenciales de esta enfermedad hacen prioritarias la elaboracion y divulgacion de protocolos diagnosticos y terapeuticos para la atencion de estos pacientes a fin de mejorar el conocimiento de esta patologia por los profesionales sanitarios potencialmente implicados en su deteccion y manejo.

Sulpiride injections in the lateral hypothalamus induce feeding and drinking in rats.

Abstract: Amphetamine injections into the lateral hypothalamus inhibit feeding. This effect is blocked by local administration of neuroleptics, suggesting a role for dopamine in feeding inhibition. However, the type of dopamine receptor involved in satiety is not known. Therefore, we tested the effect of intrahypothalamic injections of sulpiride, a specific D2 receptor blocker, on amphetamine anorexia in food-deprived rats, and on spontaneous feeding and drinking in satiated rats. Sulpiride attenuated by 36% the anorexia produced by intrahypothalamic injections of amphetamine. In satiated rats, sulpiride (8 μg/0.5 μl) elicited feeding (mean food intake after sulpiride: 5.4 g, and after vehicle 1.6 g, p<0.001), and drinking (mean water intake after sulpiride: 12.3 ml, and after vehicle: 0.9 ml, p<0.001). A dose response relationship was found between sulpiride dose and feeding or drinking. Sulpiride-induced drinking was observed in the absence of food, showing that it is not a postprandial phenomenon. These results suggest that hypothalamic D2 receptors might be involved in feeding and drinking regulation.

Study of exclusive two-photon production of W+W- in pp collisions at √s=7 TeV and constraints on anomalous quartic gauge couplings

Abstract: A search for exclusive or quasi-exclusive W(+)W(-) production by photon-photon interactions, pp to p(*)W(+)W(-)p(*), at sqrt(s) = 7 TeV is reported using data collected by the CMS detector with an integrated luminosity of 5.05 inverse femtobarns. Events are selected by requiring a mu(+/-)e(-/+) vertex with no additional associated charged tracks and dilepton transverse momentum pt(mu(+/-)e(-/+)) > 30 GeV. Two events passing all selection requirements are observed in the data, compared to a standard model expectation of 2.2 +/- 0.4 signal events with 0.84 +/- 0.15 background. The tail of the dilepton pt distribution is studied for deviations from the standard model. No events are observed with pt > 100 GeV. Model-independent upper limits are computed and compared to predictions involving anomalous quartic gauge couplings. The limits on the parameters a[W,(0,C)]/Lambda^2 with a dipole form factor and an energy cutoff Lambda(cutoff) = 500 GeV are of the order of 10E-4.