Institution
University of Pittsburgh
Education•Pittsburgh, Pennsylvania, United States•
About: University of Pittsburgh is a education organization based out in Pittsburgh, Pennsylvania, United States. It is known for research contribution in the topics: Population & Transplantation. The organization has 87042 authors who have published 201012 publications receiving 9656783 citations. The organization is also known as: Pitt & Western University of Pennsylvania.
Topics: Population, Transplantation, Poison control, Cancer, Medicine
Papers published on a yearly basis
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TL;DR: A significant treatment benefit of HDI versus GMK in terms of RFS and OS in melanoma patients at high risk of recurrence is demonstrated in this prospective, randomized, intergroup trial.
Abstract: PURPOSE: Vaccine alternatives to high-dose interferon alfa-2b therapy (HDI), the current standard adjuvant therapy for high-risk melanoma, are of interest because of toxicity associated with HDI. The GM2 ganglioside is a well-defined melanoma antigen, and anti-GM2 antibodies have been associated with improved prognosis. We conducted a prospective, randomized, intergroup trial to evaluate the efficacy of HDI for 1 year versus vaccination with GM2 conjugated to keyhole limpet hemocyanin and administered with QS-21 (GMK) for 96 weeks (weekly × 4 then every 12 weeks × 8). PATIENTS AND METHODS: Eligible patients had resected stage IIB/III melanoma. Patients were stratified by sex and number of positive nodes. Primary end points were relapse-free survival (RFS) and overall survival (OS). RESULTS: Eight hundred eighty patients were randomized (440 per treatment group); 774 patients were eligible for efficacy analysis. The trial was closed after interim analysis indicated inferiority of GMK compared with HDI. For...
856 citations
TL;DR: In this article, a review of contemporary research in children's peer relationships during the elementary and middle school years is presented, with primary focus on peer acceptance, the ability to make and maintain friendships, and their participation in larger peer networks.
855 citations
TL;DR: It is suggested that depression is associated with sustained activity in brain areas responsible for coding emotional features in response to processing negative features of information.
855 citations
TL;DR: NMDAR has intrinsic modulatory sites that are active targets for drug development, several of which show promise in preclinical/early clinical trials targeting both symptoms and cognition, and allosteric modulators, both positive and negative, may offer superior efficacy with less danger of downregulation.
855 citations
TL;DR: The Analytic Hierarchy Process (AHP) is a theory of measurement for dealing with quantifiable intangible criteria that has found rich applications in decision theory, conflict resolution and in models of the brain.
855 citations
Authors
Showing all 87737 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| JoAnn E. Manson | 270 | 1819 | 258509 |
| Graham A. Colditz | 261 | 1542 | 256034 |
| Yi Chen | 217 | 4342 | 293080 |
| David J. Hunter | 213 | 1836 | 207050 |
| David Miller | 203 | 2573 | 204840 |
| Rakesh K. Jain | 200 | 1467 | 177727 |
| Lewis C. Cantley | 196 | 748 | 169037 |
| Dennis W. Dickson | 191 | 1243 | 148488 |
| Terrie E. Moffitt | 182 | 594 | 150609 |
| Dennis S. Charney | 179 | 802 | 122408 |
| Ronald C. Petersen | 178 | 1091 | 153067 |
| David L. Kaplan | 177 | 1944 | 146082 |
| Jasvinder A. Singh | 176 | 2382 | 223370 |
| Richard K. Wilson | 173 | 463 | 260000 |
| Deborah J. Cook | 173 | 907 | 148928 |