University of Pittsburgh

About: University of Pittsburgh is a education organization based out in Pittsburgh, Pennsylvania, United States. It is known for research contribution in the topics: Population & Transplantation. The organization has 87042 authors who have published 201012 publications receiving 9656783 citations. The organization is also known as: Pitt & Western University of Pennsylvania.

Mind and World

Abstract: Modern philosophy finds it difficult to give a satisfactory picture of the place of minds in the world. In "Mind and World", based on the 1991 John Locke Lectures, John McDowell offers his diagnosis of this difficulty and points to a cure. He illustrates a major problem of modern philosophy - the insidious persistence of dualism - in his discussion of empirical thought. Much as we would like to conceive empirical thought as rationally grounded in experience, pitfalls await anyone who tries to articulate this position, and McDowell exposes these traps by exploiting the work of contemporary philosophers from Wilfrid Sellars to Donald Davidson. These difficulties, he contends, reflect an understandable - but surmountable - failure to see how we might integrate what Sellars calls "the logical space of reasons" into the natural world. What underlies this impasse is a conception of nature that has certain attractions for the modern age, a conception that McDowell proposes to put aside, thus circumventing these philosophical difficulties. By returning to a pre-modern conception of nature but retaining the intellectual advance of modernity that has mistakenly been viewed as dislodging it, he makes room for a fully satisfying conception of experience as a rational openness to independent reality. This approach also overcomes other obstacles that impede a generally satisfying understanding of how we are placed in the world.

Chemistry and Biology Of Multicomponent Reactions

Abstract: Multicomponent reactions (MCRs) are one-pot reactions employing more than two starting materials, e.g. 3, 4, … 7, where most of the atoms of the starting materials are incorporated in the final product.1 Several descriptive tags are regularly attached to MCRs (Fig. 1): they are atom economic, e.g. the majority if not all of the atoms of the starting materials are incorporated in the product; they are efficient, e.g. they efficiently yield the product since the product is formed in one-step instead of multiple sequential steps; they are convergent, e.g. several starting materials combine in one reaction to form the product; they exhibit a very high bond-forming-index (BFI), e.g. several non-hydrogen atom bonds are formed in one synthetic transformation.2 Therefore MCRs are often a useful alternative to sequential multistep synthesis. Open in a separate window Figure 1 Above: multistep syntheses can be divergent (sequential) or convergent; below: in analogy MCR reactions are convergent and one or two component reactions are divergent or less convergent.

Temporal dynamics of brain activation during a working memory task

Abstract: Working memory is responsible for the short-term storage and online manipulation of information necessary for higher cognitive functions, such as language, planning and problem-solving. Traditionally, working memory has been divided into two types of processes: executive control (governing the encoding manipulation and retrieval of information in working memory) and active maintenance (keeping information available 'online'). It has also been proposed that these two types of processes may be subserved by distinct cortical structures, with the prefrontal cortex housing the executive control processes, and more posterior regions housing the content-specific buffers (for example verbal versus visuospatial) responsible for active maintenance. However, studies in non-human primates suggest that dorsolateral regions of the prefrontal cortex may also be involved in active maintenance. We have used functional magnetic resonance imaging to examine brain activation in human subjects during performance of a working memory task. We used the temporal resolution of this technique to examine the dynamics of regional activation, and to show that prefrontal cortex along with parietal cortex appears to play a role in active maintenance.