Institution
University of Tennessee
Education•Knoxville, Tennessee, United States•
About: University of Tennessee is a education organization based out in Knoxville, Tennessee, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 41976 authors who have published 87043 publications receiving 2828517 citations. The organization is also known as: UTK & UT Knoxville.
Topics: Population, Poison control, CAS Registry Number, Context (language use), Large Hadron Collider
Papers published on a yearly basis
Papers
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Oregon State University1, Yale University2, Duke University3, University of Tennessee4, Clark University5, Kaiserslautern University of Technology6, Centraalbureau voor Schimmelcultures7, University of Copenhagen8, University of Tabriz9, Harvard University10, University of Pretoria11, ATCC12, Louisiana State University13, University of Texas at Austin14, Aberystwyth University15, United States Department of Agriculture16, Field Museum of Natural History17, Pennsylvania State University18, University of California, Berkeley19, University of North Carolina at Chapel Hill20, Stellenbosch University21, Free University of Berlin22, Washington State University23, Brandon University24, Landcare Research25, University of Helsinki26, University of Giessen27, University of Nottingham28, Swedish Museum of Natural History29, Royal Botanic Garden Edinburgh30
TL;DR: A 6-gene, 420-species maximum-likelihood phylogeny of Ascomycota, the largest phylum of Fungi, and a phylogenetic informativeness analysis of all 6 genes and a series of ancestral character state reconstructions support a terrestrial, saprobic ecology as ancestral are presented.
Abstract: We present a 6-gene, 420-species maximum-likelihood phylogeny of Ascomycota, the largest phylum of Fungi. This analysis is the most taxonomically complete to date with species sampled from all 15 currently circumscribed classes. A number of superclass-level nodes that have previously evaded resolution and were unnamed in classifications of the Fungi are resolved for the first time. Based on the 6-gene phylogeny we conducted a phylogenetic informativeness analysis of all 6 genes and a series of ancestral character state reconstructions that focused on morphology of sporocarps, ascus dehiscence, and evolution of nutritional modes and ecologies. A gene-by-gene assessment of phylogenetic informativeness yielded higher levels of informativeness for protein genes (RPB1, RPB2, and TEF1) as compared with the ribosomal genes, which have been the standard bearer in fungal systematics. Our reconstruction of sporocarp characters is consistent with 2 origins for multicellular sexual reproductive structures in Ascomycota, once in the common ancestor of Pezizomycotina and once in the common ancestor of Neolectomycetes. This first report of dual origins of ascomycete sporocarps highlights the complicated nature of assessing homology of morphological traits across Fungi. Furthermore, ancestral reconstruction supports an open sporocarp with an exposed hymenium (apothecium) as the primitive morphology for Pezizomycotina with multiple derivations of the partially (perithecia) or completely enclosed (cleistothecia) sporocarps. Ascus dehiscence is most informative at the class level within Pezizomycotina with most superclass nodes reconstructed equivocally. Character-state reconstructions support a terrestrial, saprobic ecology as ancestral. In contrast to previous studies, these analyses support multiple origins of lichenization events with the loss of lichenization as less frequent and limited to terminal, closely related species.
592 citations
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TL;DR: A national registry of United States residents with XLA was established in 1999 to provide an updated clinical view of the disorder in a large cohort of patients and found that patients with a positive family history at the time of their birth were diagnosed before clinical symptoms developed.
590 citations
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Northwestern University1, University of California, San Francisco2, University of Michigan3, City of Hope National Medical Center4, Vanderbilt University5, Seattle Cancer Care Alliance6, Fox Chase Cancer Center7, University of Wisconsin-Madison8, University of Texas Southwestern Medical Center9, University of Utah10, University of Nebraska Medical Center11, University of Alabama at Birmingham12, University of California, Los Angeles13, University of South Florida14, Mayo Clinic15, Washington University in St. Louis16, Yale Cancer Center17, Stanford University18, Case Western Reserve University19, University of Colorado Boulder20, Brigham and Women's Hospital21, Ohio State University22, Roswell Park Cancer Institute23, University of Texas MD Anderson Cancer Center24, Harvard University25, University of California, San Diego26, Memorial Sloan Kettering Cancer Center27, University of Pennsylvania28, University of Tennessee29, Johns Hopkins University30, Duke University31, National Comprehensive Cancer Network32
TL;DR: The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Colon Cancer focuses on systemic therapy options for the treatment of metastatic colorectal cancer (mCRC), because important updates have recently been made to this section as discussed by the authors.
Abstract: This selection from the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Colon Cancer focuses on systemic therapy options for the treatment of metastatic colorectal cancer (mCRC), because important updates have recently been made to this section. These updates include recommendations for first-line use of checkpoint inhibitors for mCRC, that is deficient mismatch repair/microsatellite instability-high, recommendations related to the use of biosimilars, and expanded recommendations for biomarker testing. The systemic therapy recommendations now include targeted therapy options for patients with mCRC that is HER2-amplified, or BRAF V600E mutation-positive. Treatment and management of nonmetastatic or resectable/ablatable metastatic disease are discussed in the complete version of the NCCN Guidelines for Colon Cancer available at NCCN.org. Additional topics covered in the complete version include risk assessment, staging, pathology, posttreatment surveillance, and survivorship.
589 citations
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TL;DR: The present review is a synopsis of compounds that have been reported in the past decade that have provided an increase in understanding of the actions of CBSIs.
Abstract: Tubulin dynamics is a promising target for new chemotherapeutic agents. The colchicine binding site is one of the most important pockets for potential tubulin polymerization destabilizers. Colchicine binding site inhibitors (CBSI) exert their biological effects by inhibiting tubulin assembly and suppressing microtubule formation. A large number of molecules interacting with the colchicine binding site have been designed and synthesized with significant structural diversity. CBSIs have been modified as to chemical structure as well as pharmacokinetic properties, and tested in order to find a highly potent, low toxicity agent for treatment of cancers. CBSIs are believed to act by a common mechanism via binding to the colchicine site on tubulin. The present review is a synopsis of compounds that have been reported in the past decade that have provided an increase in our understanding of the actions of CBSIs.
588 citations
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TL;DR: A complete phylogeny for all 271 extant species of the Garnivora is derived, providing a ‘consensus’ estimate of carnivore phylogeny and showing that some lineages within the Mustelinae and Canidae contain significantly more species than expected for their age, illustrating the tree's utility for studies of macroevolution.
Abstract: One way to build larger, more comprehensive phylogenies is to combine the vast amount of phylogenetic information already available. We review the two main strategies for accomplishing this (combining raw data versus combining trees), but employ a relatively new variant of the latter: supertree construction. The utility of one supertree technique, matrix representation using parsimony analysis (MRP), is demonstrated by deriving a complete phylogeny for all 271 extant species of the Carnivora from 177 literature sources. Beyond providing a ‘consensus’ estimate of carnivore phylogeny, the tree also indicates taxa for which the relationships remain controversial (e.g. the red panda; within canids, felids, and hyaenids) or have not been studied in any great detail (e.g. herpestids, viverrids, and intrageneric relationships in the procyonids). Times of divergence throughout the tree were also estimated from 74 literature sources based on both fossil and molecular data. We use the phylogeny to show that some lineages within the Mustelinae and Canidae contain significantly more species than expected for their age, illustrating the tree’s utility for studies of macroevolution. It will also provide a useful foundation for comparative and conservational studies involving the carnivores.
587 citations
Authors
Showing all 42211 results
Name | H-index | Papers | Citations |
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Zhong Lin Wang | 245 | 2529 | 259003 |
David Miller | 203 | 2573 | 204840 |
Bradley Cox | 169 | 2150 | 156200 |
Alexander S. Szalay | 166 | 936 | 145745 |
J. E. Brau | 162 | 1949 | 157675 |
Robert Stone | 160 | 1756 | 167901 |
Robert G. Webster | 158 | 843 | 90776 |
Zhenwei Yang | 150 | 956 | 109344 |
Sevil Salur | 147 | 1470 | 106407 |
Ching-Hon Pui | 145 | 805 | 72146 |
Tim Adye | 143 | 1898 | 109010 |
Teruki Kamon | 142 | 2034 | 115633 |
Nicholas A. Peppas | 141 | 825 | 90533 |
Krzysztof Piotrzkowski | 141 | 1269 | 99607 |
Yuri Gershtein | 139 | 1558 | 104279 |