Institution
Wroclaw University of Environmental and Life Sciences
Education•Wrocław, Poland•
About: Wroclaw University of Environmental and Life Sciences is a education organization based out in Wrocław, Poland. It is known for research contribution in the topics: Population & GNSS applications. The organization has 3108 authors who have published 6672 publications receiving 57774 citations.
Topics: Population, GNSS applications, Yarrowia, Soil water, Flavonols
Papers published on a yearly basis
Papers
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TL;DR: It is demonstrated here that cell exposition to bFGF in 5 and 10 ng/mL dosages results in improved morphology, increased proliferative activity, reduced cellular senescence and apoptosis, and decreased oxidative stress, indicating recovery of ASCs' function impaired by T2D.
Abstract: Type 2 diabetes (T2D) is a chronic metabolic disorder affecting increasing number of people in developed countries. Therefore new strategies for treatment of T2D and its complications are of special interest. Nowadays, cellular therapies involving mesenchymal stromal cells that reside in adipose tissue (ASCs) constitute a promising approach; however, there are still many obstacles concerning safety and effectiveness that need to be overcome before ASCs could be engaged for the treatment of diabetes mellitus. One of the challenges is preventing ASCs from deterioration caused by elevated oxidative stress present in diabetes milieu. In the current study we investigated the effect of basic fibroblast growth factor (bFGF) treatment on ASCs isolated from patients with diagnosed T2D. We demonstrate here that cell exposition to bFGF in 5 and 10 ng/mL dosages results in improved morphology, increased proliferative activity, reduced cellular senescence and apoptosis, and decreased oxidative stress, indicating recovery of ASCs’ function impaired by T2D. Therefore our results provide a support for bFGF as a potential therapeutic agent for improving stem cell-based approaches for the treatment of diabetes mellitus and its complications.
46 citations
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TL;DR: It was found that tested chalcones possessed highly selective antiproliferative activity towards all tested breast cancer lines compared to the normal breast MCF 10A cell line (the calculated selectivity index ranged from 5 to 10).
Abstract: Xanthohumol (XN) and four minor hops prenylflavonoids: α,β-dihydroxanthohumol (2HXN), isoxanthohumol (IXN), 8-prenylnaringenin (8PN), and 6-prenylnaringenin (6PN), were tested for antiproliferative activity towards human cancer and normal cell lines. Nonprenylated naringenin (NG) was used as a model compound. Xanthohumol, α,β-dihydroxanthohumol and 6-prenylnaringenin were the most active compounds. Xanthohumol exhibited higher antiproliferative activity than cisplatin (CP) against five cancer cell lines: ovarian resistant to cisplatin A2780cis, breast MDA-MB-231 and T-47D, prostate PC-3, and colon HT-29. Isoxanthohumol was more potent than cisplatin against breast cancer cell lines MDA-MB-231 and T-47D whereas 6-prenylnaringenin was stronger than cisplatin against breast cancer cell line T-47D. It was found that tested chalcones possessed highly selective antiproliferative activity towards all tested breast cancer lines compared to the normal breast MCF 10A cell line (the calculated selectivity index ranged from 5 to 10). Low antiproliferative activity of naringenin indicates the importance of the prenyl group with respect to antiproliferative activity.
46 citations
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TL;DR: The results indicate that the addition of NAC (5 mM) and SOD (200 U/mL) is beneficial for the function of frozen-thawed chicken spermatozoa and can be recommended as an additional component of chicken freezing extender.
46 citations
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TL;DR: In this article, the influence of peeling, cooking and frying of red and blue-fleshed potato tubers on the content of glycoalkaloids (α-solanine and α-chaconine) in processed potato products was determined.
46 citations
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TL;DR: Isoxanthohumol (IXN) is one of the most important prenylflavonoids found in hops and shows an antiviral activity towards herpes viruses (HSV1 and HSV2) and bovine viral diarrhea virus (BVDV).
46 citations
Authors
Showing all 3137 results
Name | H-index | Papers | Citations |
---|---|---|---|
Jan Oszmiański | 47 | 204 | 8514 |
Aneta Wojdyło | 40 | 182 | 6832 |
Francesco Sansone | 37 | 135 | 4977 |
Guido Viscardi | 35 | 176 | 3832 |
Jan Szopa | 33 | 169 | 4054 |
Henryk Okarma | 33 | 65 | 3264 |
Gaetano Donofrio | 32 | 141 | 3882 |
Andrzej Zalewski | 31 | 85 | 2372 |
Adam Figiel | 30 | 94 | 3309 |
Krzysztof Marycz | 30 | 197 | 3121 |
Waldemar Rymowicz | 29 | 91 | 2560 |
Pierluigi Quagliotto | 28 | 93 | 2330 |
Alfonso Moriana | 28 | 84 | 2489 |
Joost van Hoof | 26 | 95 | 2964 |
Nadia Barbero | 25 | 85 | 1642 |