Journal ArticleDOI
Gain at chromosomal region 5p15.33, containing TERT, is the most frequent genetic event in early stages of non-small cell lung cancer
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TLDR
A high-resolution array comparative genomic hybridization study using an array of 4,046 bacterial artificial chromosome clones to screen for DNA copy number changes associated with individual genes in 36 tumors obtained from patients in early stages of NSCLC identified a series of genes in the critical 5p15.33 region that may be used as novel biomarkers for the early detection and classification of lung cancer.About:
This article is published in Cancer Genetics and Cytogenetics.The article was published on 2008-04-01. It has received 167 citations till now. The article focuses on the topics: Chromosomal region & Comparative genomic hybridization.read more
Citations
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Journal ArticleDOI
Sequence variants at the TERT-CLPTM1L locus associate with many cancer types.
Thorunn Rafnar,Patrick Sulem,Simon N. Stacey,Frank Geller,Julius Gudmundsson,Asgeir Sigurdsson,Margret Jakobsdottir,Hafdis T. Helgadottir,Steinunn Thorlacius,Katja K H Aben,Thorarinn Blondal,Thorgeir E. Thorgeirsson,Gudmar Thorleifsson,Kristleifur Kristjansson,Kristin Thorisdottir,Rafn Ragnarsson,Bardur Sigurgeirsson,Halla Skuladottir,Tomas Gudbjartsson,Helgi J Isaksson,Gudmundur V. Einarsson,Kristrun R. Benediktsdottir,Bjarni A. Agnarsson,Karl Olafsson,Anna Salvarsdottir,Hjordis Bjarnason,Margret Asgeirsdottir,Kari T. Kristinsson,Sigurborg Matthiasdottir,Steinunn G Sveinsdottir,Silvia Polidoro,Veronica Höiom,Rafael Botella-Estrada,Kari Hemminki,Peter Rudnai,D. Timothy Bishop,Marcello Campagna,Eliane Kellen,Maurice P. Zeegers,Maurice P. Zeegers,Petra J. de Verdier,Ana Ferrer,Dolores Isla,Maria Vidal,Raquel Andrés,Berta Saez,Pablo Juberías,Javier Banzo,Sebastian Navarrete,Alejandro Tres,Donghui Kan,Annika Lindblom,Eugene Gurzau,Kvetoslava Koppova,Femmie de Vegt,Jack A. Schalken,Henricus F. M. van der Heijden,Hans J Smit,René A Termeer,Egbert Oosterwijk,Onno van Hooij,Eduardo Nagore,Stefano Porru,Gunnar Steineck,Gunnar Steineck,Johan Hansson,Frank Buntinx,Frank Buntinx,William J. Catalona,Giuseppe Matullo,Paolo Vineis,Anne E. Kiltie,Jose I. Mayordomo,Rajesh Kumar,Lambertus A. Kiemeney,Michael L. Frigge,Thorvaldur Jonsson,Hafsteinn Saemundsson,Rosa B. Barkardottir,Eirikur Jonsson,Steinn Jonsson,Jón Ólafsson,Jeffrey R. Gulcher,Gisli Masson,Daniel F. Gudbjartsson,Augustine Kong,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Kari Stefansson,Kari Stefansson +89 more
TL;DR: It is found that rs401681[C] on chromosome 5p15 satisfied the threshold for genome-wide significance and seems to confer protection against cutaneous melanoma, and investigation of the region led to rs2736098[A], which showed stronger association with some cancer types, but neither variant could fully account for the association of the other.
Journal ArticleDOI
Common 5p15.33 and 6p21.33 variants influence lung cancer risk.
Yufei Wang,Peter Broderick,Emily L. Webb,Xifeng Wu,Jayaram Vijayakrishnan,Athena Matakidou,Mobshra Qureshi,Qiong Dong,Xiangjun Gu,Wei Vivien Chen,Margaret R. Spitz,Timothy Eisen,Christopher I. Amos,Richard S. Houlston +13 more
TL;DR: A genome-wide association study of lung cancer comparing 511,919 SNP genotypes in 1,952 cases and 1,438 controls confirmed the most significant association was attained at 15q25.1 and identified two newly associated risk loci mapping to 6p21.33 and 5p15.33.
Journal ArticleDOI
Telomeric and extra-telomeric roles for telomerase and the telomere-binding proteins
Paula Martínez,Maria A. Blasco +1 more
TL;DR: The role of telomeric proteins in cancer and ageing through modulating telomere length and protection, as well as regulating gene expression by binding to non-telomeric sites is discussed.
Journal ArticleDOI
Variants near DMRT1 , TERT and ATF7IP are associated with testicular germ cell cancer
Clare Turnbull,Elizabeth A. Rapley,Sheila Seal,David Pernet,Anthony Renwick,Deborah Hughes,Michelle Ricketts,Rachel Linger,Jérémie Nsengimana,Panagiotis Deloukas,Robert Huddart,D. Timothy Bishop,Douglas F. Easton,Michael R. Stratton,Nazneen Rahman +14 more
TL;DR: A genome-wide association study for testicular germ cell tumor is conducted, genotyping 298,782 SNPs in 979 affected individuals and 4,947 controls from the UK and replicating associations in a further 664 cases and 3,456 controls.
Journal ArticleDOI
DHHC palmitoyl transferases: substrate interactions and (patho)physiology
TL;DR: This work has highlighted how DHHC proteins regulate cell function and influence physiology and pathophysiology and there is now a major effort to identify DHHC-substrate pairings and to determine how interaction specificity is encoded.
References
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Journal ArticleDOI
Specific association of human telomerase activity with immortal cells and cancer
Nam Woo Kim,Mieczyslaw A. Piatyszek,Karen R. Prowse,Calvin B. Harley,Michael D. West,Peter L. C. Ho,Gina M. Coviello,Woodring E. Wright,Scott L. Weinrich,Jerry W. Shay +9 more
TL;DR: A highly sensitive assay for measuring telomerase activity was developed in this paper, which showed that telomerases appear to be stringently repressed in normal human somatic tissues but reactivated in cancer, where immortal cells are likely required to maintain tumor growth.
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Extension of life-span by introduction of telomerase into normal human cells
Andrea G. Bodnar,Michel M. Ouellette,Maria Frolkis,Shawn E. Holt,Choy-Pik Chiu,Gregg B. Morin,Calvin B. Harley,Jerry W. Shay,Serge Lichtsteiner,Woodring E. Wright +9 more
TL;DR: In this article, two telomerase-negative normal human cell types, retinal pigment epithelial cells and foreskin fibroblasts, were transfected with vectors encoding the human telomere catalytic subunit.
Journal ArticleDOI
High resolution analysis of DNA copy number variation using comparative genomic hybridization to microarrays
Daniel Pinkel,Daniel Pinkel,Richard Segraves,Damir Sudar,Steven M. Clark,Ian Poole,David Kowbel,Colin Collins,Wen Lin Kuo,Chira Chen,Ye Zhai,Shanaz H. Dairkee,Britt-Marie Ljung,Joe W. Gray,Joe W. Gray,Donna G. Albertson,Donna G. Albertson,Donna G. Albertson +17 more
TL;DR: The implementation of array CGH is demonstrated to be able to measure copy number with high precision in the human genome, and to analyse clinical specimens by obtaining new information on chromosome 20 aberrations in breast cancer.
Journal ArticleDOI
Cancer burden in the year 2000. The global picture.
TL;DR: Three elementary measures of cancer frequency are confined ourselves to: incidence, mortality and prevalence.
Journal ArticleDOI
Telomerase catalytic subunit homologs from fission yeast and human
Toru Nakamura,Gregg B. Morin,Gregg B. Morin,Karen B. Chapman,Karen B. Chapman,Scott L. Weinrich,Scott L. Weinrich,William H. Andrews,William H. Andrews,Joachim Lingner,Joachim Lingner,Calvin B. Harley,Calvin B. Harley,Thomas R. Cech,Thomas R. Cech +14 more
TL;DR: In this paper, the homologous genes from the fission yeast Schizosaccharomyces pombe and human are identified and the proposed telomerase catalytic subunits represent a deep branch in the evolution of reverse transcriptases.
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