Journal ArticleDOI
Molecular evidence linking primary cancer of the fallopian tube to BRCA1 germline mutations.
Ronald P. Zweemer,P. J. Van Diest,R Verheijen,Andy Ryan,Johan J.P. Gille,Rolf H. Sijmons,Ian Jacobs,Fred H. Menko,Peter Kenemans +8 more
TLDR
Findings provide the first molecular evidence that Fallopian tube cancer may be due to germline mutations in BRCA1, and may have important consequences for the preferred method of prophylactic oophorectomy in B RCA1 mutation carriers.About:
This article is published in Gynecologic Oncology.The article was published on 2000-01-01. It has received 185 citations till now. The article focuses on the topics: Fallopian tube cancer & Fallopian tube.read more
Citations
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Journal ArticleDOI
Cancer Incidence in BRCA1 Mutation Carriers
TL;DR: In carriers of BRCA1 mutations, the overall increased risk of cancer at sites other than breast and ovary is small and is observed in women but generally not in men.
Journal ArticleDOI
Dysplastic changes in prophylactically removed Fallopian tubes of women predisposed to developing ovarian cancer
Jurgen M.J. Piek,P. J. Van Diest,Ronald P. Zweemer,J W Jansen,Ria J.J. Poort-Keesom,Fred H. Menko,Johan J.P. Gille,A P M Jongsma,Gerard Pals,Peter Kenemans,R Verheijen +10 more
TL;DR: The Fallopian tubes of women predisposed to developing ovarian cancer frequently harbour dysplastic changes, accompanied by changes in cell‐cycle and apoptosis‐related proteins, indicating an increased risk of developing tubal cancer.
Journal ArticleDOI
Cancer Risk Estimates for BRCA1 Mutation Carriers Identified in a Risk Evaluation Program
Marcia S. Brose,Timothy R. Rebbeck,Kathleen A. Calzone,Jill Stopfer,Katherine L. Nathanson,Barbara L. Weber +5 more
TL;DR: Estimating BRCA1-related cancer risks for individuals ascertained in a breast cancer risk evaluation clinic is higher than population-based estimates but lower than estimates based on families ascertained for linkage studies, which may most closely approximate those faced by BRCa1 mutation carriers identified in risk evaluation clinics.
Journal ArticleDOI
Primary Fallopian Tube Malignancies in BRCA-Positive Women Undergoing Surgery for Ovarian Cancer Risk Reduction
Michael J. Callahan,Christopher P. Crum,Fabiola Medeiros,David Kindelberger,Julia A. Elvin,Judy Garber,Colleen M. Feltmate,Ross S. Berkowitz,Michael G. Muto +8 more
TL;DR: The distal fallopian tube seems to be the dominant site of origin for early malignancies detected in approximately 6% of women undergoing ovarian cancer risk-reduction surgery, and the greatest proportion of serous cancer risk in BRCA mutation-positive women should be assigned to the fimbria rather than the ovary.
Journal ArticleDOI
The distal fallopian tube: a new model for pelvic serous carcinogenesis.
Christopher P. Crum,Ronny Drapkin,Alexander Miron,Tan A. Ince,Michael G. Muto,David Kindelberger,Yonghee Lee +6 more
TL;DR: The emerging data offer compelling evidence for a model of ‘fimbrial-ovarian’ serous neoplasia, and call attention to the distal fallopian tube as an important source for this disease, the study of which could clarify pathways to cancer in both organs and generate novel strategies for cancer prevention.
References
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Journal ArticleDOI
Genetic Heterogeneity and Penetrance Analysis of the BRCA1 and BRCA2 Genes in Breast Cancer Families
D Ford,Douglas F. Easton,Michael R. Stratton,Steven A. Narod,David E. Goldgar,Peter Devilee,D. T. Bishop,Barbara L. Weber,Gilbert M. Lenoir,Jenny Chang-Claude,Hagay Sobol,M D Teare,Jeffery P. Struewing,Adalgeir Arason,Siegfried Scherneck,Julian Peto,Timothy R. Rebbeck,Patricia N. Tonin,Susan L. Neuhausen,Rosa B. Barkardottir,Jorunn E. Eyfjord,Henry T. Lynch,Bruce A.J. Ponder,Simon A. Gayther,J.M. Birch,Annika Lindblom,Dominique Stoppa-Lyonnet,Y. J. Bignon,Åke Borg,U Hamann,Neva E. Haites,Rodney J. Scott,Christine Maugard,Hans F. A. Vasen,Susanne Seitz,Lisa A. Cannon-Albright,Andrew Craig Schofield,Moraima Zelada-Hedman +37 more
TL;DR: The lifetime risk of breast cancer appears similar to the risk in BRCA1 carriers, but there was some suggestion of a lower risk in bRCA2 carriers <50 years of age.
Journal ArticleDOI
Risks of cancer in BRCA1-mutation carriers
TL;DR: In this paper, the risks of breast and ovarian cancer from the occurrence of second cancers in individuals with breast cancer, and examined the risk of other cancers in BRCA1 carriers.
Journal Article
Breast and ovarian cancer incidence in BRCA1-mutation carriers. Breast Cancer Linkage Consortium.
TL;DR: Data from families with evidence of linkage to BRCA1 is used to estimate the age-specific risks of breast and ovarian cancer in BRCa1-mutation carriers and to examine the variation in risk between and within families.
Journal Article
Recurrent dislocation of the shoulder.
TL;DR: Recurrent Dislocation of the Shoulder: An Inquiry into the Mechanism and its Applications in Psychiatry.
Journal ArticleDOI
Allele losses in the region 17q12-21 in familial breast and ovarian cancer involve the wild-type chromosome
TL;DR: In four multiple case breast-ovarian cancer families, it is found that in each of nine tumours which showed allele losses, the losses were from the wild–type chromosome, suggesting that the putative ‘breast–ovarian’ cancer gene is indeed a tumour suppressor gene.