Pluronic block copolymers: evolution of drug delivery concept from inert nanocarriers to biological response modifiers.
Reads0
Chats0
TLDR
These studies suggest that Pluronics have a broad spectrum of biological response modifying activities which make it one of the most potent drug targeting systems available, resulting in a remarkable impact on the emergent field of nanomedicine.About:
This article is published in Journal of Controlled Release.The article was published on 2008-09-10 and is currently open access. It has received 1111 citations till now. The article focuses on the topics: Targeted drug delivery & Drug delivery.read more
Citations
More filters
Journal ArticleDOI
Principles of nanoparticle design for overcoming biological barriers to drug delivery
TL;DR: By successively addressing each of the biological barriers that a particle encounters upon intravenous administration, innovative design features can be rationally incorporated that will create a new generation of nanotherapeutics, realizing a paradigmatic shift in nanoparticle-based drug delivery.
Journal ArticleDOI
Degradable Controlled-Release Polymers and Polymeric Nanoparticles: Mechanisms of Controlling Drug Release
Journal ArticleDOI
Endocytosis of Nanomedicines
TL;DR: This review describes the current experimental tools to study endocytosis of nanomedicines and provides specific examples from recent literature and the authors' own work on endocyTosis of Nanomedicine.
Journal ArticleDOI
Targeted Drug Delivery with Polymers and Magnetic Nanoparticles: Covalent and Noncovalent Approaches, Release Control, and Clinical Studies.
TL;DR: This review covers the principles, advantages, and drawbacks of passive and active targeting based on various polymer and magnetic iron oxide nanoparticle carriers with drug attached by both covalent and noncovalent pathways.
Journal ArticleDOI
Diverse Applications of Nanomedicine
Beatriz Pelaz,Christoph Alexiou,Ramon A. Alvarez-Puebla,Frauke Alves,Frauke Alves,Anne M. Andrews,Sumaira Ashraf,Lajos P. Balogh,Laura Ballerini,Alessandra Bestetti,Cornelia Brendel,Susanna Bosi,Mónica Carril,Warren C. W. Chan,Chunying Chen,Xiaodong Chen,Xiaoyuan Chen,Zhen Cheng,Daxiang Cui,Jianzhong Du,Christian Dullin,Alberto Escudero,Alberto Escudero,Neus Feliu,Mingyuan Gao,Michael D. George,Yury Gogotsi,Arnold Grünweller,Zhongwei Gu,Naomi J. Halas,Norbert Hampp,Roland K. Hartmann,Mark C. Hersam,Patrick Hunziker,Ji Jian,Xingyu Jiang,Philipp Jungebluth,Pranav Kadhiresan,Kazunori Kataoka,Ali Khademhosseini,Jindřich Kopeček,Nicholas A. Kotov,Harald F. Krug,Dong Soo Lee,Claus-Michael Lehr,Kam W. Leong,Xing-Jie Liang,Mei Ling Lim,Luis M. Liz-Marzán,Xiaowei Ma,Paolo Macchiarini,Huan Meng,Helmuth Möhwald,Paul Mulvaney,Andre E. Nel,Shuming Nie,Peter Nordlander,Teruo Okano,Jose Oliveira,Tai Hyun Park,Reginald M. Penner,Maurizio Prato,Maurizio Prato,Víctor F. Puntes,Vincent M. Rotello,Amila Samarakoon,Raymond E. Schaak,Youqing Shen,Sebastian Sjöqvist,Andre G. Skirtach,Andre G. Skirtach,Mahmoud Soliman,Molly M. Stevens,Hsing-Wen Sung,Ben Zhong Tang,Rainer Tietze,Buddhisha Udugama,J. Scott VanEpps,Tanja Weil,Tanja Weil,Paul S. Weiss,Itamar Willner,Yuzhou Wu,Yuzhou Wu,Lily Yang,Zhao Yue,Qian Zhang,Qiang Zhang,Xian-En Zhang,Yuliang Zhao,Xin Zhou,Wolfgang J. Parak +91 more
TL;DR: An overview of recent developments in nanomedicine is provided and the current challenges and upcoming opportunities for the field are highlighted and translation to the clinic is highlighted.
References
More filters
Journal ArticleDOI
Targeting multidrug resistance in cancer
Gergely Szakács,Jill K. Paterson,Joseph A. Ludwig,Catherine Booth-Genthe,Michael M. Gottesman +4 more
TL;DR: Various approaches to combating multidrug-resistant cancer are described, including the development of drugs that engage, evade or exploit efflux by ABC transporters.
Journal ArticleDOI
Pluronic® block copolymers as novel polymer therapeutics for drug and gene delivery
TL;DR: The interactions of the Pluronic unimers with multidrug-resistant cancer cells result in sensitization of these cells with respect to various anticancer agents and the single molecular chains of copolymer, unimers, inhibit drug efflux transporters in both the blood-brain barrier and in the small intestine.
Journal ArticleDOI
Micellar nanocontainers distribute to defined cytoplasmic organelles.
TL;DR: Block copolymer micelles are water-soluble biocompatible nanocontainers with great potential for delivering hydrophobic drugs but localization in several cytoplasmic organelles, including mitochondria, but not in the nucleus is revealed.
Journal ArticleDOI
Overcoming Multidrug resistance in cancer: An update on the clinical strategy of inhibiting P-glycoprotein
Hilary Thomas,Helen M. Coley +1 more
TL;DR: Third-generation P-gp inhibitors have shown promise in clinical trials and may establish the true therapeutic potential of P- gp-mediated MDR reversal, and pharmacokinetic studies to date have shown no appreciable impact on cytochrome P450 3A4 drug metabolism and no clinically significant drug interactions with common chemotherapy agents.
Journal ArticleDOI
Soft nanotechnology with soft nanoparticles.
Satish Nayak,L. Andrew Lyon +1 more
TL;DR: This review will present some of the recent advances in the marriage between water-swellable networks and nanoscience, as well as new classes of soft nanomaterials are being developed from more traditional polymeric constructs.