Showing papers in "Journal of Pharmaceutical and Biomedical Analysis in 2011"

TL;DR: In this review, the set-up and data interpretation of experimental designs (screening, response surface, and mixture designs) are discussed and an adaptation of the algorithm of Dong and the estimation of factor effects from supersaturated design results are discussed.

TL;DR: A review work on different nutraceuticals found in natural matrices together with the analytical techniques used to identify and/or quantify them with special emphasis in the period January 2005-May 2010 is presented.

TL;DR: The commonly used solid-state analytical techniques, the type of information collected, and advantages and disadvantages of each technique are discussed, with the focus on their application inSolid-state characterization and monitoring solid- state transformations, such as amorphization, crystallization, hydrate formation/dehydration and cocrystal formation.

TL;DR: Potential applications of robust metabolomics apporoaches in the area of traditional oriental medicine are summarized, and the key role of metabolomics to resolve special TCM issues is highlighted.

TL;DR: This review focuses on recent advances in novel SPME techniques, including fiber S PME and in-tube SPMe, in biomedical analysis and summarizes the applications of these techniques to pharmacotherapeutic, forensic, and diagnostic studies, and to determinations of environmental and occupational exposure.

TL;DR: This review intends to reflect the impact of LC-MS for medicinal plant analysis focusing on most relevant reports published within the last five years.

TL;DR: This review summarizes the analytical techniques available for intact protein determination and the main development steps in which they are applicable and highlights how several analytical strategies are necessary to obtain global information.

TL;DR: There is a great variability in the amount of the active compounds: the content of total phenolic acids ranged from 0.17 to 16.67mg/ml and the level of total flavonoids from 2.48 to 41.10 mg/ml.

TL;DR: On the basis of the specific fragmentation of glycyrrhizic acid, an LC-MS/MS method was developed in order to quantify the analyte in the liquorice root samples.

TL;DR: The strategies for quantification, related to the markers, reference compounds and approaches, in quality control of CM were reviewed and discussed and the valid method for quantitatively evaluating the quality of CM is poor.

TL;DR: This review summarises the analytical approaches reported in the literature relating to hydrazine, hydrazines, Hydrazides and hydrazones to provide guidance for analysts needing to develop procedures to control such impurities, particularly where this is due to concerns relating to their potential genotoxicity.

TL;DR: Several essential aspects of methods validation, not only restricted to chromatographic ones but also to ligand binding assays owing to their increasing role in biopharmaceutical industries are discussed and highlighted.

TL;DR: A simple and rapid ultrasound-assisted dispersive liquid-liquid microextraction (UA-DLLME) coupled with liquid chromatography-ultraviolet detection (LC-UV) was developed for the determination of four fluoroquinolones in pharmaceutical wastewater samples.

TL;DR: A possible interaction was found between the KT with polyvinylpyrrolidone K30 and magnesium stearate, which could influence the stability of the KT in the binary mixtures.

TL;DR: This paper describes the implementation of a bioanalytical study plan for the validation of immunoassays to support decision-making biomarkers and biomarker selection during preclinical and clinical studies and defines milestones and decision points to be followed during the assay validation.

TL;DR: The first part of this article presents an overview of the advantages and limitations of NMR for in vitro quantitative analysis of complex matrices in liquid or semi-solid phases and describes the in vivo clinical magnetic resonance spectroscopy techniques.

TL;DR: The experimental results revealed the static quenching mechanism in the interaction of TRP with protein and the hydrogen bond and van der Waals forces played the major role in the binding of TRp to proteins.

TL;DR: Recommendations on best practices for the validation of cell-based NAb assay and suggested validation parameters based on the experience of the authors are provided.

TL;DR: It was shown for both electronic tongue systems that ionic substances are easier to detect than neutral ones and offer the opportunity to be used for the development of taste-masked pharmaceutical formulations.

TL;DR: Recent advances in transmission Raman spectroscopy enable rapid non-invasive volumetric analysis of pharmaceutical formulations and could lead to many important applications in pharmaceutical settings, including quantitative bulk analysis of intact pharmaceutical tablets and capsules in quality and process control.

TL;DR: A simple, sensitive, and validated LC-MS/MS method was applied to simultaneously quantify BAs and BA-sulfates in both male and female mouse tissues and fluids, providing strong evidence that sulfation is a minor metabolic pathway of BA elimination and detoxification in mice.

TL;DR: An ultra-sensitive liquid chromatography tandem mass spectrometry (LC-MS/MS) assay was developed and validated to facilitate the assessment of clinical pharmacokinetics of nucleotide analogs from lysed intracellular matrix and was successfully applied to clinical research samples generating novel intrACEllular information for TFV, FTC, ZDV, and 3TC nucleotides.

TL;DR: It was observed that metabolic perturbations induced by chronic variable stress were restored in a time-dependent pattern after treatment with CSGS, which suggested that the therapeutic effect of CSGS on depression may involve in regulating the dysfunctions of energy metabolism, tryptophan metabolism, bone loss and liver detoxification.

TL;DR: This review gives an overview of the application of quantitative NMR spectroscopy and DOSY NMR in anticounterfeiting.

TL;DR: A pH gradient-based separation method using cation exchange chromatography was shown to be robust for monoclonal antibodies and suitable for its intended purpose of charge heterogeneity analysis, demonstrating the superior precision and robustness of this multi-product method.

TL;DR: Increased flow rates can be applied on sub-2 μm core-shell columns to accomplish very fast separations without significant loss in efficiency, according to this study.

TL;DR: The present review focuses on recent examples of mechanistic aspects of capillary electromigration enantioseparations and summarizes recent applications of chiral pharmaceutical and biomedical analysis published between January 2009 and August 2010.

TL;DR: The automated system described in this article represents an efficient tool for the LC/MS/MS analysis of DBS samples in many bioanalytical applications and showed good precision, trueness, and linearity over the expected concentration range.

TL;DR: General advantages and disadvantages of CE for sample fingerprinting will be discussed and methods will be classified depending on the detection system (UV or MS) as this strongly affects all the conditions.

TL;DR: A new and validated HPLC method for the simultaneous determination of bioactive compounds in Centaurium erythraea, Frasera caroliniensis and Gentiana lutea is presented and polyoxygenated xanthones within the three members of the Gentianaceae family are discussed.