Journal ArticleDOI
3d Transition Metals for C-H Activation.
Parthasarathy Gandeepan,Thomas Müller,Daniel Zell,Gianpiero Cera,Svenja Warratz,Lutz Ackermann +5 more
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TLDR
A comprehensive overview on first row transition metal catalysts for C-H activation until summer 2018 is provided.Abstract:
C–H activation has surfaced as an increasingly powerful tool for molecular sciences, with notable applications to material sciences, crop protection, drug discovery, and pharmaceutical industries, among others. Despite major advances, the vast majority of these C–H functionalizations required precious 4d or 5d transition metal catalysts. Given the cost-effective and sustainable nature of earth-abundant first row transition metals, the development of less toxic, inexpensive 3d metal catalysts for C–H activation has gained considerable recent momentum as a significantly more environmentally-benign and economically-attractive alternative. Herein, we provide a comprehensive overview on first row transition metal catalysts for C–H activation until summer 2018.read more
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Carbon Dioxide Hydrogenation to Formate Catalyzed by a Bench-Stable, Non-Pincer-Type Mn(I) Alkylcarbonyl Complex.
TL;DR: The well-defined, bench-stable alkylcarbonyl Mn(I) bis(phosphine) complex was tested as an efficient and selective non-precious-metal precatalyst for the hydrogenation of CO2 to formate under mild conditions.
Journal ArticleDOI
Exploiting Strained Rings in Chelation Guided C‐H Functionalization: Integration of C‐H Activation with Ring Cleavage
TL;DR: This review will focus on recent developments in transition-metal catalyzed chelation assisted concomitant C-H activation and ring scission of strained rings to attain molecular complexity.
Journal ArticleDOI
Synthesis of benzoazepine derivatives via Rh(III)-catalyzed inert C(sp2)–H functionalization and [4 + 3] annulation
TL;DR: With this method, a series of hybrid compounds combining the biologically promising imidazole and benzoazepine moieties decorated with a synthetically versatile carboxyl group were prepared in moderate to good efficiency and the utility was remarkably showcased by their efficient transformations into some otherwise difficult-to-obtain pentacyclic compounds.
Journal ArticleDOI
Peroxide-mediated site-specific C–H methylation of imidazo[1,2-a]pyridines and quinoxalin-2(1H)-ones under metal-free conditions
TL;DR: Methylated imidazopyridines and quinoxalin-2(1H)-ones were smoothly synthesized in moderate to good yields and a free radical reaction mechanism was proposed to describe the methylation process.
Journal ArticleDOI
Cobalt-catalyzed dehydrogenative functionalization of alcohols: Progress and future prospect
TL;DR: In this article , the advancement in cobalt-catalyzed, both homogeneous and heterogeneous, dehydrogenation of alcohols, numerous CC and CN bond formation reactions, synthesis of heterocycles, and other valuable products formation following the borrowing hydrogen (BH) and acceptorless dehydrogenative coupling (ADC) strategy.
References
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Journal ArticleDOI
Palladium-Catalyzed Ligand-Directed C−H Functionalization Reactions
TL;DR: This is the first comprehensive review encompassing the large body of work in this field over the past 5 years, and will focus specifically on ligand-directed C–H functionalization reactions catalyzed by palladium.
Journal ArticleDOI
Fluorine in Pharmaceuticals: Looking Beyond Intuition.
TL;DR: Experimental progress in exploration of the specific influence of carbon-fluorine single bonds on docking interactions is reviewed and complementary analysis based on comprehensive searches in the Cambridge Structural Database and the Protein Data Bank is added.
Book ChapterDOI
Heavy metal toxicity and the environment.
TL;DR: This review provides an analysis of arsenic, cadmium, chromium, lead, and mercury's environmental occurrence, production and use, potential for human exposure, and molecular mechanisms of toxicity, genotoxicity, and carcinogenicity.
Journal ArticleDOI
Understanding TiO2 photocatalysis: mechanisms and materials.
Jenny Schneider,Masaya Matsuoka,Masato Takeuchi,Jinlong Zhang,Yu Horiuchi,Masakazu Anpo,Detlef W. Bahnemann +6 more
TL;DR: This paper presents a meta-analyses of the chiral stationary phase transition of Na6(CO3)(SO4)2, Na2SO4, and Na2CO3 of the Na2O/Na2O 2 mixture at the stationary phase and shows clear patterns in the response of these two materials to each other.
Journal ArticleDOI
Organic Photoredox Catalysis
TL;DR: An overview of the basic photophysics and electron transfer theory is presented in order to provide a comprehensive guide for employing this class of catalysts in photoredox manifolds.