Journal ArticleDOI
3d Transition Metals for C-H Activation.
Parthasarathy Gandeepan,Thomas Müller,Daniel Zell,Gianpiero Cera,Svenja Warratz,Lutz Ackermann +5 more
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TLDR
A comprehensive overview on first row transition metal catalysts for C-H activation until summer 2018 is provided.Abstract:
C–H activation has surfaced as an increasingly powerful tool for molecular sciences, with notable applications to material sciences, crop protection, drug discovery, and pharmaceutical industries, among others. Despite major advances, the vast majority of these C–H functionalizations required precious 4d or 5d transition metal catalysts. Given the cost-effective and sustainable nature of earth-abundant first row transition metals, the development of less toxic, inexpensive 3d metal catalysts for C–H activation has gained considerable recent momentum as a significantly more environmentally-benign and economically-attractive alternative. Herein, we provide a comprehensive overview on first row transition metal catalysts for C–H activation until summer 2018.read more
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Metal-Organic Framework-Based Catalysts with Single Metal Sites.
TL;DR: This review overviews the recent developments of catalysis at single metal sites in MOF-based materials with emphasis on their structures and applications for thermocatalysis, electrocatalysis, and photocatalysis.
Journal ArticleDOI
N-Heterocyclic Carbene Complexes in C–H Activation Reactions
TL;DR: Through discussing the role of NHC ligands in promoting challenging C-H activation methods, the reader is provided with an overview of this important area and its crucial role in forging carbon-carbon and carbon-heteroatom bonds by directly engaging ubiquitous C- H bonds.
Journal ArticleDOI
Enantioselective C-H Activation with Earth-Abundant 3d Transition Metals.
TL;DR: The remarkable recent progress in enantioselective transformations via organometallic C-H activation by 3d base metals until April 2019 is discussed.
Journal ArticleDOI
Recent advances in the synthesis of axially chiral biaryls via transition metal-catalysed asymmetric C–H functionalization
TL;DR: An overview of recent advances in the synthesis of axially chiral biaryl motifs via transition metal-catalysed asymmetric C-H functionalization is provided.
Journal ArticleDOI
C-H Activation: Toward Sustainability and Applications.
TL;DR: In this article, the authors highlight the research areas seeking to overcome the sustainability challenges of C-H activation: the pursuit of abundant metal catalysts, the avoidance of static directing groups, the replacement of metal oxidants, and the introduction of bioderived solvents.
References
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Synthesis of Carbocyclic and Heterocyclic β-Aminocarboxylic Acids
TL;DR: These compounds are found in natural products and antibiotics, and are also considered important precursors for pharmacologically interesting β-lactams and other bioactive compounds.
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Palladium-Catalyzed Double C ? H Activation Directed by Sulfoxides in the Synthesis of Dibenzothiophenes
TL;DR: In this paper, the method is applied to the synthesis of dibenzothiophenes from simple benzyl phenyl sulfoxides, and the synthesis is shown to be successful.
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Room-temperature aerobic formation of a stable aryl–Cu(III) complex and its reactions with nucleophiles: highly efficient and diverse arene C–H functionalizations of azacalix[1]arene[3]pyridine
TL;DR: Under very mild aerobic conditions, azacalix[1]arene[3]pyridine underwent highly efficient C-H activation with Cu(ClO(4))(2).6H(2)O to form a stable aryl-Cu(III) complex which reacted rapidly with various nucleophiles at ambient temperature to afford diverse functionalized azacalspine derivatives in excellent yields.
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Cobalt-Catalyzed Chemoselective Insertion of Alkene into the Ortho C−H Bond of Benzamide
TL;DR: Notable features of this reaction include the structural variety of the alkene and the amide substrate and the tolerance of functional groups such as halide, olefin, ester, and amide groups.
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Cp*CoIII‐Catalyzed C2‐Selective Addition of Indoles to Imines
TL;DR: In this paper, the utility of a Co(III) catalyst to promote the C2-selective addition of indoles to imines is demonstrated, and the utility is further analyzed.