Journal ArticleDOI
3d Transition Metals for C-H Activation.
Parthasarathy Gandeepan,Thomas Müller,Daniel Zell,Gianpiero Cera,Svenja Warratz,Lutz Ackermann +5 more
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TLDR
A comprehensive overview on first row transition metal catalysts for C-H activation until summer 2018 is provided.Abstract:
C–H activation has surfaced as an increasingly powerful tool for molecular sciences, with notable applications to material sciences, crop protection, drug discovery, and pharmaceutical industries, among others. Despite major advances, the vast majority of these C–H functionalizations required precious 4d or 5d transition metal catalysts. Given the cost-effective and sustainable nature of earth-abundant first row transition metals, the development of less toxic, inexpensive 3d metal catalysts for C–H activation has gained considerable recent momentum as a significantly more environmentally-benign and economically-attractive alternative. Herein, we provide a comprehensive overview on first row transition metal catalysts for C–H activation until summer 2018.read more
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Metal-Organic Framework-Based Catalysts with Single Metal Sites.
TL;DR: This review overviews the recent developments of catalysis at single metal sites in MOF-based materials with emphasis on their structures and applications for thermocatalysis, electrocatalysis, and photocatalysis.
Journal ArticleDOI
N-Heterocyclic Carbene Complexes in C–H Activation Reactions
TL;DR: Through discussing the role of NHC ligands in promoting challenging C-H activation methods, the reader is provided with an overview of this important area and its crucial role in forging carbon-carbon and carbon-heteroatom bonds by directly engaging ubiquitous C- H bonds.
Journal ArticleDOI
Enantioselective C-H Activation with Earth-Abundant 3d Transition Metals.
TL;DR: The remarkable recent progress in enantioselective transformations via organometallic C-H activation by 3d base metals until April 2019 is discussed.
Journal ArticleDOI
Recent advances in the synthesis of axially chiral biaryls via transition metal-catalysed asymmetric C–H functionalization
TL;DR: An overview of recent advances in the synthesis of axially chiral biaryl motifs via transition metal-catalysed asymmetric C-H functionalization is provided.
Journal ArticleDOI
C-H Activation: Toward Sustainability and Applications.
TL;DR: In this article, the authors highlight the research areas seeking to overcome the sustainability challenges of C-H activation: the pursuit of abundant metal catalysts, the avoidance of static directing groups, the replacement of metal oxidants, and the introduction of bioderived solvents.
References
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Journal ArticleDOI
Iron-Catalyzed Ortho C–H Methylation of Aromatics Bearing a Simple Carbonyl Group with Methylaluminum and Tridentate Phosphine Ligand
TL;DR: A combination of a mildly reactive methylaluminum reagent and a new tridentate phosphine ligand for metal catalysis that allows us to convert an ortho C-H bond to a C-CH3 bond in aromatics and heteroaromatics bearing simple carbonyl groups under mild oxidative conditions is described.
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Manganese- and Borane-Mediated Synthesis of Isobenzofuranones from Aromatic Esters and Oxiranes via C-H Bond Activation.
TL;DR: This is the first example of a manganese-catalyzed C-H transformation using an oxygen-directing group and Triphenylborane played an important role in this reaction to cooperatively promote the annulation reaction.
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Direct Conversion of Carbon-Hydrogeninto Carbon-Carbon Bonds by First-Row Transition-MetalCatalysis
Amol A. Kulkarni,Olafs Daugulis +1 more
TL;DR: In this article, a review summarizes first-row transition-metal catalysis for the conversion of carbon-hydrogen into carbon-carbon bonds, including manganese, iron, cobalt, copper, and nickel.
Journal ArticleDOI
Direct, catalytic, and regioselective synthesis of 2-alkyl-, aryl-, and alkenyl-substituted N-heterocycles from N-oxides.
TL;DR: The utility of this one-step transformation of heterocyclic N-oxides to 2-alkyl-, aryl-, and alkenyl-substituted N-heterocycles is exemplified by facile syntheses of new structural analogues of several antimalarial, antimicrobial, and fungicidal agents.
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Ru(II)-catalyzed amidation of 2-arylpyridines with isocyanates via C-H activation.
TL;DR: An efficient Ru(II)-catalyzed amidation of 2-arylpyridines with isocyanates with isOCyanates via C-H bond activation is described.