Journal ArticleDOI
3d Transition Metals for C-H Activation.
Parthasarathy Gandeepan,Thomas Müller,Daniel Zell,Gianpiero Cera,Svenja Warratz,Lutz Ackermann +5 more
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TLDR
A comprehensive overview on first row transition metal catalysts for C-H activation until summer 2018 is provided.Abstract:
C–H activation has surfaced as an increasingly powerful tool for molecular sciences, with notable applications to material sciences, crop protection, drug discovery, and pharmaceutical industries, among others. Despite major advances, the vast majority of these C–H functionalizations required precious 4d or 5d transition metal catalysts. Given the cost-effective and sustainable nature of earth-abundant first row transition metals, the development of less toxic, inexpensive 3d metal catalysts for C–H activation has gained considerable recent momentum as a significantly more environmentally-benign and economically-attractive alternative. Herein, we provide a comprehensive overview on first row transition metal catalysts for C–H activation until summer 2018.read more
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Metal-Organic Framework-Based Catalysts with Single Metal Sites.
TL;DR: This review overviews the recent developments of catalysis at single metal sites in MOF-based materials with emphasis on their structures and applications for thermocatalysis, electrocatalysis, and photocatalysis.
Journal ArticleDOI
N-Heterocyclic Carbene Complexes in C–H Activation Reactions
TL;DR: Through discussing the role of NHC ligands in promoting challenging C-H activation methods, the reader is provided with an overview of this important area and its crucial role in forging carbon-carbon and carbon-heteroatom bonds by directly engaging ubiquitous C- H bonds.
Journal ArticleDOI
Enantioselective C-H Activation with Earth-Abundant 3d Transition Metals.
TL;DR: The remarkable recent progress in enantioselective transformations via organometallic C-H activation by 3d base metals until April 2019 is discussed.
Journal ArticleDOI
Recent advances in the synthesis of axially chiral biaryls via transition metal-catalysed asymmetric C–H functionalization
TL;DR: An overview of recent advances in the synthesis of axially chiral biaryl motifs via transition metal-catalysed asymmetric C-H functionalization is provided.
Journal ArticleDOI
C-H Activation: Toward Sustainability and Applications.
TL;DR: In this article, the authors highlight the research areas seeking to overcome the sustainability challenges of C-H activation: the pursuit of abundant metal catalysts, the avoidance of static directing groups, the replacement of metal oxidants, and the introduction of bioderived solvents.
References
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Indole Synthesis via Cobalt(III)-Catalyzed Oxidative Coupling of N-Arylureas and Internal Alkynes.
TL;DR: A mild Co(III)-catalyzed oxidative annulation of N-arylureas and internal alkynes has been developed, providing a new opportunity for the synthesis of diverse indoles.
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Mechanistic Basis for Regioselection and Regiodivergence in Nickel-Catalyzed Reductive Couplings
Evan P. Jackson,Hasnain A. Malik,Grant J. Sormunen,Ryan D. Baxter,Peng Liu,Hengbin Wang,Abdur Rafay Shareef,John Montgomery +7 more
TL;DR: These studies present a detailed picture of the influences that control regioselectivity in a specific catalytic reaction, and delineate strategies for regiocontrol that may extend to numerous classes of reactions.
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Air-stable phosphine oxides as preligands for catalytic activation reactions of C-Cl, C-F, and C-H bonds
TL;DR: In this article, the use of easily accessible heteroatom-substituted secondary phosphine oxides as preligands for cross-coupling reactions is described, and they enable nickel-catalyzed coupling reactions of magnesium organyls with aryl fluo- rides at ambient temperature.
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Copper-Mediated Hydroxylation of Arenes and Heteroarenes Directed by a Removable Bidentate Auxiliary
TL;DR: A copper-mediated C-H hydroxylation of arenes and heteroarenes using the authors' newly developed PIP directing group has been developed, providing an operationally simple protocol for the synthesis of o-hydroxybenzamides.
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CH Alkenylations with Alkenyl Acetates, Phosphates, Carbonates, and Carbamates by Cobalt Catalysis at 23 °C†
TL;DR: The versatile cobalt catalyst was broadly applicable and thus also allowed for the efficient conversion of alkenyl phosphates, carbonates, and carbamates at ambient temperature.