Journal ArticleDOI
3d Transition Metals for C-H Activation.
Parthasarathy Gandeepan,Thomas Müller,Daniel Zell,Gianpiero Cera,Svenja Warratz,Lutz Ackermann +5 more
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TLDR
A comprehensive overview on first row transition metal catalysts for C-H activation until summer 2018 is provided.Abstract:
C–H activation has surfaced as an increasingly powerful tool for molecular sciences, with notable applications to material sciences, crop protection, drug discovery, and pharmaceutical industries, among others. Despite major advances, the vast majority of these C–H functionalizations required precious 4d or 5d transition metal catalysts. Given the cost-effective and sustainable nature of earth-abundant first row transition metals, the development of less toxic, inexpensive 3d metal catalysts for C–H activation has gained considerable recent momentum as a significantly more environmentally-benign and economically-attractive alternative. Herein, we provide a comprehensive overview on first row transition metal catalysts for C–H activation until summer 2018.read more
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Metal-Organic Framework-Based Catalysts with Single Metal Sites.
TL;DR: This review overviews the recent developments of catalysis at single metal sites in MOF-based materials with emphasis on their structures and applications for thermocatalysis, electrocatalysis, and photocatalysis.
Journal ArticleDOI
N-Heterocyclic Carbene Complexes in C–H Activation Reactions
TL;DR: Through discussing the role of NHC ligands in promoting challenging C-H activation methods, the reader is provided with an overview of this important area and its crucial role in forging carbon-carbon and carbon-heteroatom bonds by directly engaging ubiquitous C- H bonds.
Journal ArticleDOI
Enantioselective C-H Activation with Earth-Abundant 3d Transition Metals.
TL;DR: The remarkable recent progress in enantioselective transformations via organometallic C-H activation by 3d base metals until April 2019 is discussed.
Journal ArticleDOI
Recent advances in the synthesis of axially chiral biaryls via transition metal-catalysed asymmetric C–H functionalization
TL;DR: An overview of recent advances in the synthesis of axially chiral biaryl motifs via transition metal-catalysed asymmetric C-H functionalization is provided.
Journal ArticleDOI
C-H Activation: Toward Sustainability and Applications.
TL;DR: In this article, the authors highlight the research areas seeking to overcome the sustainability challenges of C-H activation: the pursuit of abundant metal catalysts, the avoidance of static directing groups, the replacement of metal oxidants, and the introduction of bioderived solvents.
References
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Journal ArticleDOI
Intermolecular pinacol cross coupling of electronically similar aldehydes. An efficient and stereoselective synthesis of 1,2-diols employing a practical vanadium(II) reagent
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Carbon–Carbon Bond Formation in a Weak Ligand Field: Leveraging Open-Shell First-Row Transition-Metal Catalysts
TL;DR: Unique features of earth-abundant transition-metal catalysts are reviewed in the context of catalytic carbon-carbon bond-forming reactions, a deviation from traditional strong-field organometallic compounds that promote catalytic C-C bond formation.
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Mechanistic understanding of Rh-catalyzed N-sulfonylaldimine insertion into aryl C–H bonds
TL;DR: The studies indicate that N-tosyl aldimine insertion into the C–Rh bonds rather than C–H bond activation or protonolysis is the rate-determining step, which has significant implications for the development of a more efficient catalytic reaction system.
Journal ArticleDOI
Palladium-Catalyzed Heck Cross-Coupling Reactions in Water: A Comprehensive Review
Fadri Christoffel,Thomas R. Ward +1 more
TL;DR: In this article, a review summarizes the different approaches pursued to perform Heck reactions in neat water as well as aqueous mixtures, including homogeneous and immobilized catalysts, including nanoparticles.
Journal ArticleDOI
Cobalt-Porphyrin-Catalysed Intramolecular Ring-Closing C-H Amination of Aliphatic Azides: A Nitrene-Radical Approach to Saturated Heterocycles.
Petrus F. Kuijpers,Martijn J. Tiekink,Willem B. Breukelaar,Daniël L. J. Broere,Nicolaas P. van Leest,Jarl Ivar van der Vlugt,Joost N. H. Reek,Bas de Bruin +7 more
TL;DR: Kinetic studies of the reaction in combination with DFT calculations reveal a metallo‐radical‐type mechanism involving rate‐limiting azide activation to form the key cobalt(III)‐nitrene radical intermediate that enables direct synthesis of various N‐heterocycles from aliphatic azides.