A Central role for mTOR in lipid homeostasis.
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TLDR
The mechanistic target of rapamycin (mTOR) signaling pathway regulates many fundamental metabolic and physiological processes, including lipid metabolism, with an emphasis on recent findings from in vivo models regarding the role of mTORC2 in lipolysis, lipogenesis, and adipogenesis.About:
This article is published in Cell Metabolism.The article was published on 2013-10-01 and is currently open access. It has received 306 citations till now. The article focuses on the topics: mTORC2 & Lipid metabolism.read more
Citations
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Journal ArticleDOI
mTOR Signaling in Growth, Metabolism, and Disease.
TL;DR: Recent advances in understanding of mTOR function, regulation, and importance in mammalian physiology are reviewed and how the mTOR signaling network contributes to human disease is highlighted.
mTOR Signaling in Growth, Metabolism, and Disease
TL;DR: Recent advances in understanding of mTOR function, regulation, and importance in mammalian physiology are reviewed and how the mTOR-signaling network contributes to human disease is highlighted.
Journal ArticleDOI
The Nrf2 regulatory network provides an interface between redox and intermediary metabolism
TL;DR: Observations suggest Nrf2 directs metabolic reprogramming during stress, which would enable the factor to orchestrate adaptive responses to diverse forms of stress.
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Making new contacts: the mTOR network in metabolism and signalling crosstalk
TL;DR: Emerging evidence provides new insight into the control of mTOR by other pathways such as Hippo, WNT and Notch signalling, and this progress has expanded the list of downstream effectors and upstream regulators of m TOR signalling.
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Pheochromocytoma and paraganglioma pathogenesis: learning from genetic heterogeneity.
TL;DR: Hereditary pheochromocytomas and paragangliomas are powerful models for recognizing cancer driver events, which can be harnessed for diagnostic purposes and for guiding the future development of targeted therapies.
References
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Journal ArticleDOI
mTOR signaling in growth control and disease.
TL;DR: Recent advances in understanding of the mTOR pathway are reviewed and pharmacological approaches to treat human pathologies linked to mTOR deregulation are discussed.
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Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1
Katrin Düvel,Jessica L. Yecies,Suchithra Menon,Pichai Raman,Alex Lipovsky,Amanda Souza,Ellen Triantafellow,Qicheng Ma,Regina Gorski,Stephen Cleaver,Matthew G. Vander Heiden,Jeffrey P. MacKeigan,Peter Finan,Clary B. Clish,Leon Murphy,Brendan D. Manning +15 more
TL;DR: It is demonstrated that mTORC1 activation is sufficient to stimulate specific metabolic pathways, including glycolysis, the oxidative arm of the pentose phosphate pathway, and de novo lipid biosynthesis, through the activation of a transcriptional program affecting metabolic gene targets of hypoxia-inducible factor and sterol regulatory element-binding protein.
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DEPTOR Is an mTOR Inhibitor Frequently Overexpressed in Multiple Myeloma Cells and Required for Their Survival
Timothy R. Peterson,Mathieu Laplante,Carson C. Thoreen,Yasemin Sancak,Seong A. Kang,W. Michael Kuehl,Nathanael S. Gray,David M. Sabatini +7 more
TL;DR: A novel mTOR-interacting protein whose deregulated overexpression in multiple myeloma cells represents a mechanism for activating PI3K/Akt signaling and promoting cell survival.
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SREBP Activity Is Regulated by mTORC1 and Contributes to Akt-Dependent Cell Growth
Thomas Porstmann,Claudio R. Santos,B. Griffiths,Megan Cully,Mary Wu,Sally J. Leevers,John R. Griffiths,Yuen-Li Chung,Almut Schulze +8 more
TL;DR: The results suggest that the PI3K/Akt/TOR pathway regulates protein and lipid biosynthesis in an orchestrated manner and that both processes are required for cell growth.
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Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity
Dudley W. Lamming,Lan Ye,Pekka Katajisto,Marcus D. Goncalves,Maki Saitoh,Deanna Stevens,James G. Davis,Adam B. Salmon,Arlan Richardson,Rexford S. Ahima,David A. Guertin,David M. Sabatini,Joseph A. Baur +12 more
TL;DR: In this article, the authors demonstrate that rapamycin disrupted a second mTOR complex, mTORC2, in vivo and that mTORc2 was required for the insulin-mediated suppression of hepatic gluconeogenesis.