A Deep Learning Approach to Antibiotic Discovery
Jonathan M. Stokes,Kevin Yang,Kyle Swanson,Wengong Jin,Andres Cubillos-Ruiz,Nina M. Donghia,Craig R. MacNair,Shawn French,Lindsey A. Carfrae,Zohar Bloom-Ackermann,Victoria M. Tran,Anush Chiappino-Pepe,Ahmed H. Badran,Ian W. Andrews,Ian W. Andrews,Ian W. Andrews,Emma J. Chory,George M. Church,Eric D. Brown,Tommi S. Jaakkola,Regina Barzilay,James J. Collins +21 more
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TLDR
A deep neural network capable of predicting molecules with antibacterial activity is trained and a molecule from the Drug Repurposing Hub-halicin- is discovered that is structurally divergent from conventional antibiotics and displays bactericidal activity against a wide phylogenetic spectrum of pathogens.About:
This article is published in Cell.The article was published on 2020-02-20 and is currently open access. It has received 1002 citations till now.read more
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DeepPurpose: a deep learning library for drug-target interaction prediction.
TL;DR: DeepPurpose as discussed by the authors is a comprehensive and easy-to-use DL library for drug-target interaction prediction, which supports training of customized DTI prediction models by implementing 15 compound and protein encoders and over 50 neural architectures.
Journal ArticleDOI
Repurpose Open Data to Discover Therapeutics for COVID-19 Using Deep Learning.
Xiangxiang Zeng,Xiang Song,Tengfei Ma,Xiaoqin Pan,Yadi Zhou,Yuan Hou,Zheng Zhang,Kenli Li,George Karypis,Feixiong Cheng,Feixiong Cheng,Feixiong Cheng +11 more
TL;DR: There have been more than 2.2 million confirmed cases and over 120,000 deaths from the human coronavirus disease 2019 (COVID-19) pandemic, caused by the novel severe acute respiratory syndrome coro...
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Artificial Intelligence in the Battle against Coronavirus (COVID-19): A Survey and Future Research Directions
TL;DR: A survey of AI methods being used in various applications in the fight against the COVID-19 outbreak is presented and the crucial roles of AI research in this unprecedented battle are outlined.
Journal ArticleDOI
Materials design by synthetic biology
Tzu-Chieh Tang,Bolin An,Bolin An,Yuanyuan Huang,Sangita Vasikaran,Yanyi Wang,Xiaoyu Jiang,Timothy K. Lu,Chao Zhong,Chao Zhong +9 more
TL;DR: In this paper, the authors discuss synthetic-biology tools, including genetic circuits, model organisms and design parameters, which can be applied for the construction of smart living materials, such as self-organizing functional materials.
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Antibiotic resistance and persistence-Implications for human health and treatment perspectives.
TL;DR: This review focuses on bacterial mechanisms allowing evasion of antibiotic killing and discusses their implications on human health, including the relationship between antibiotic persistence and bacterial heterogeneity, and discusses recent studies that link bacterial persistence and tolerance with the evolution of antibiotic resistance.
References
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Extended-Connectivity Fingerprints
David Rogers,Mathew Hahn +1 more
TL;DR: A description of their implementation has not previously been presented in the literature, and ECFPs can be very rapidly calculated and can represent an essentially infinite number of different molecular features.