A Stress-Responsive System for Mitochondrial Protein Degradation
Jin-Mi Heo,Nurit Livnat-Levanon,Eric B. Taylor,Kevin T. Jones,Noah Dephoure,Julia Ring,Jianxin Xie,Jeffrey L. Brodsky,Frank Madeo,Steven P. Gygi,Kaveh Ashrafi,Michael H. Glickman,Jared Rutter +12 more
TLDR
It is demonstrated that Ydr049 (renamed VCP/Cdc48-associated mitochondrial stress-responsive--Vms1), a member of an unstudied pan-eukaryotic protein family, translocates from the cytosol to mitochondria upon mitochondrial stress.About:
This article is published in Molecular Cell.The article was published on 2010-11-12 and is currently open access. It has received 281 citations till now. The article focuses on the topics: DNAJA3 & mitochondrial fusion.read more
Citations
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Mitochondria: In Sickness and in Health
TL;DR: This work provides a current view of how mitochondrial functions impinge on health and disease and identifies mitochondrial dysfunction as a key factor in a myriad of diseases, including neurodegenerative and metabolic disorders.
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The role of iron and reactive oxygen species in cell death
TL;DR: The different roles of iron in triggering cell death, targets of iron-dependent ROS that mediate cell death and a new form ofIron-dependent cell death termed ferroptosis are described to suggest new therapeutic avenues to treat cancer, organ damage and degenerative disease.
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Emerging functions of the VCP/p97 AAA-ATPase in the ubiquitin system
TL;DR: These findings extend the functional relevance of p97 to lysosomal degradation and reveal a surprising dual role in protecting cells from protein stress and ensuring genome stability during proliferation.
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Proteostasis and aging
Susmita Kaushik,Ana Maria Cuervo +1 more
TL;DR: Recent developments that highlight the multidimensional nature of the proteostasis networks, which allow for coordinated protein homeostasis intracellularly, in between cells and even across organs, as well as on how they affect common age-associated diseases when they malfunction in aging are focused on.
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A new pathway for mitochondrial quality control: mitochondrial‐derived vesicles
TL;DR: The Parkinson's disease‐associated proteins Vps35, Parkin, and PINK1 are involved in the biogenesis of a subset of these MDVs, linking this novel trafficking pathway to human disease.
References
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Journal ArticleDOI
Global analysis of protein expression in yeast
Sina Ghaemmaghami,Won-Ki Huh,Kiowa Bower,Russell W. Howson,Archana Belle,Noah Dephoure,Erin K. O'Shea,Jonathan S. Weissman +7 more
TL;DR: A Saccharomyces cerevisiae fusion library is created where each open reading frame is tagged with a high-affinity epitope and expressed from its natural chromosomal location, and it is found that about 80% of the proteome is expressed during normal growth conditions.
Journal ArticleDOI
A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine
TL;DR: The mitochondria provide a direct link between the authors' environment and their genes and the mtDNA variants that permitted their forbears to energetically adapt to their ancestral homes are influencing their health today.
Journal ArticleDOI
STRING 8—a global view on proteins and their functional interactions in 630 organisms
Lars Juhl Jensen,Michael Kuhn,Manuel Stark,Samuel Chaffron,Christopher J. Creevey,Jean Muller,T. Doerks,Philippe Julien,Alexander Roth,Milan Simonovic,Peer Bork,Christian von Mering +11 more
TL;DR: The most important new developments in STRING 8 over previous releases include a URL-based programming interface, improved interaction prediction via genomic neighborhood in prokaryotes, and the inclusion of protein structures.
Journal ArticleDOI
Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans
Coleen T. Murphy,Steven A. McCarroll,Cornelia I. Bargmann,Andrew G. Fraser,Ravi S. Kamath,Julie Ahringer,Hao Li,Cynthia Kenyon +7 more
TL;DR: The findings suggest that the insulin/IGF-I pathway ultimately exerts its effect on lifespan by upregulating a wide variety of genes, including cellular stress-response, antimicrobial and metabolic genes, and by downregulating specific life-shortening genes.
Journal ArticleDOI
The tandem affinity purification (TAP) method: a general procedure of protein complex purification.
Oscar Puig,Friederike Caspary,Guillaume Rigaut,Berthold Rutz,Emmanuelle Bouveret,Elisabeth Bragado-Nilsson,Matthias Wilm,Bertrand Séraphin +7 more
TL;DR: The TAP method is developed as a tool that allows rapid purification under native conditions of complexes, even when expressed at their natural level, and is a very useful procedure for protein purification and proteome exploration.