Journal ArticleDOI
Activating transcription factor 4
Kurosh Ameri,Adrian L. Harris +1 more
TLDR
Since ATF4 is induced by tumour microenvironmental factors, and regulates processes relevant to cancer progression, it might serve as a potential therapeutic target in cancer.About:
This article is published in The International Journal of Biochemistry & Cell Biology.The article was published on 2008-01-01. It has received 476 citations till now. The article focuses on the topics: Activating Transcription Factor 4 & Activating transcription factor.read more
Citations
More filters
Journal ArticleDOI
The unfolded protein response: controlling cell fate decisions under ER stress and beyond
TL;DR: Insight is provided into the regulatory mechanisms and signalling crosstalk of the three branches of the UPR, which are initiated by the stress sensors protein kinase RNA-like ER kinase (PERK), inositol-requiring protein 1α (IRE1α) and activating transcription factor 6 (ATF6).
Journal ArticleDOI
The integrated stress response.
Karolina Pakos-Zebrucka,Izabela Koryga,Katarzyna Mnich,Mila Ljujic,Afshin Samali,Adrienne M. Gorman +5 more
TL;DR: Current understanding of the ISR signaling is reviewed and how it regulates cell fate under diverse types of stress is reviewed.
Journal ArticleDOI
The eIF2α/ATF4 pathway is essential for stress-induced autophagy gene expression
Wafa B'chir,Anne-Catherine Maurin,Valérie Carraro,Julien Averous,Céline Jousse,Yuki Muranishi,Laurent Parry,Georges Stepien,Pierre Fafournoux,Alain Bruhat +9 more
TL;DR: A novel regulatory role of the eIF2α–ATF4 pathway is revealed in the fine-tuning of the autophagy gene transcription program in response to stresses.
Journal ArticleDOI
Targeting the unfolded protein response in disease
TL;DR: Recent advances in the design of novel compounds and therapeutic strategies to manipulate levels of ER stress in disease are discussed.
Journal ArticleDOI
The eIF2α kinases: their structures and functions
TL;DR: While significant sequence similarity exists between the eIF2α kinases in their kinase domains, underlying their common role in phosphorylating eif2α, additional unique features determine the regulation of these four proteins, that is, what signals activate them.
References
More filters
Journal ArticleDOI
Regulated Translation Initiation Controls Stress-Induced Gene Expression in Mammalian Cells
Heather P. Harding,Isabel Novoa,Yuhong Zhang,Huiqing Zeng,Ronald C. Wek,Matthieu Schapira,David Ron +6 more
TL;DR: Protein kinases that phosphorylate the alpha subunit of eukaryotic initiation factor 2 (eIF2alpha) are activated in stressed cells and negatively regulate protein synthesis, resulting in the induction of the downstream gene CHOP (GADD153).
Journal ArticleDOI
An Integrated Stress Response Regulates Amino Acid Metabolism and Resistance to Oxidative Stress
Heather P. Harding,Yuhong Zhang,Huiquing Zeng,Isabel Novoa,Phoebe D. Lu,Marcella Calfon,Navid Sadri,Chi Yun,Brian Popko,Richard S. Paules,David F. Stojdl,John C. Bell,Thore Hettmann,Jeffrey M. Leiden,David Ron +14 more
TL;DR: A signaling pathway initiated by eIF2alpha phosphorylation protects cells against metabolic consequences of ER oxidation by promoting the linked processes of amino acid sufficiency and resistance to oxidative stress.
Journal ArticleDOI
p53 Regulates Mitochondrial Respiration
Satoaki Matoba,Ju Gyeong Kang,Ju Gyeong Kang,Willmar D. Patino,Willmar D. Patino,Andrew Wragg,Andrew Wragg,Manfred Boehm,Manfred Boehm,Oksana Gavrilova,Oksana Gavrilova,Paula J. Hurley,Paula J. Hurley,Fred Bunz,Fred Bunz,Paul M. Hwang,Paul M. Hwang +16 more
TL;DR: It is shown that p53, one of the most frequently mutated genes in cancers, modulates the balance between the utilization of respiratory and glycolytic pathways, and Synthesis of Cytochrome c Oxidase 2 (SCO2) is identified as the downstream mediator of this effect.
Journal ArticleDOI
Binding of a nuclear protein to the cyclic-AMP response element of the somatostatin gene.
TL;DR: The cAMP-dependent pathway may regulate gene transcription in response to hormonal stimulation by phosphorylating this CREB protein, characterized in PC 12 cells which binds selectively to the CRE in the somatostatin gene.
Journal ArticleDOI
Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity.
Tsonwin Hai,Tom Curran +1 more
TL;DR: It is suggested that the Fos/Jun and ATF/CREB families of transcription factors, which function in coupling extracellular signals to alterations in expression of specific target genes, can be grouped into a superfamily of transcription factor.