Adipose tissues as an ancestral immune organ: site-specific change in obesity.
Sylvie Caspar-Bauguil,Béatrice Cousin,Anne Galinier,C. Segafredo,Maryse Nibbelink,Mireille André,Louis Casteilla,Luc Pénicaud +7 more
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TLDR
Cytofluorometric analysis reveals the presence of significant levels of lymphocytes in the stroma‐vascular fraction of white adipose tissues, supporting the notion that adipose tissue may elaborate immunological mechanisms to regulate its functions which might be altered in obesity.About:
This article is published in FEBS Letters.The article was published on 2005-07-04 and is currently open access. It has received 239 citations till now. The article focuses on the topics: Adipose tissue & Adipose tissue macrophages.read more
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Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters
Markus Feuerer,Laura Herrero,Laura Herrero,Daniela Cipolletta,Afia Naaz,Jamie Wong,Jamie Wong,Ali Nayer,Jongsoon Lee,Allison B. Goldfine,Christophe Benoist,Steven E. Shoelson,Diane Mathis +12 more
TL;DR: Observations suggest that harnessing the anti-inflammatory properties of Treg cells to inhibit elements of the metabolic syndrome may have therapeutic potential.
Journal ArticleDOI
Normalization of obesity-associated insulin resistance through immunotherapy.
Shawn Winer,Yin Chan,Geoffrey Paltser,Dorothy Truong,Hubert Tsui,Jasmine Bahrami,Ruslan Dorfman,Yongqian Wang,Julian Zielenski,Fabrizio G. Mastronardi,Yuko Maezawa,Daniel J. Drucker,Edgar G. Engleman,Daniel A. Winer,H.-Michael Dosch +14 more
TL;DR: It is discovered that CD4+ T lymphocytes, resident in visceral adipose tissue (VAT), control insulin resistance in mice with diet-induced obesity (DIO), andalyses of human tissue suggest that a similar process may also occur in humans.
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Concise review: adipose tissue-derived stromal cells--basic and clinical implications for novel cell-based therapies.
TL;DR: Compared with bone marrow‐derived mesenchymal stem cells, adipose tissue‐derived stromal cells (ADSC) do have an equal potential to differentiate into cells and tissues of mesodermal origin, such as adipocytes, cartilage, bone, and skeletal muscle, but the easy and repeatable access to subcutaneous adipOSE tissue and the simple isolation procedures provide a clear advantage.
Journal ArticleDOI
B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies
Daniel A. Winer,Shawn Winer,Shawn Winer,Lei Shen,Persis P. Wadia,Jason Yantha,Geoffrey Paltser,Hubert Tsui,Ping Wu,Matthew G. Davidson,Michael N. Alonso,Hwei X Leong,Alec J. Glassford,Maria Caimol,Justin A. Kenkel,Thomas F. Tedder,Tracey McLaughlin,David B. Miklos,H.-M. Dosch,Edgar G. Engleman +19 more
TL;DR: The results establish the importance of B cells and adaptive immunity in insulin resistance and suggest new diagnostic and therapeutic modalities for managing the disease.
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Adipocyte Death, Adipose Tissue Remodeling, and Obesity Complications
Katherine J. Strissel,Zlatina S. Stancheva,Hideaki Miyoshi,James W. Perfield,Jason DeFuria,Zoe Jick,Andrew S. Greenberg,Martin S. Obin +7 more
TL;DR: These results implicate depot-selective adipocyte death and MΦ-mediated AT remodeling in inflammatory and metabolic complications of murine obesity.
References
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Obesity is associated with macrophage accumulation in adipose tissue
Stuart P. Weisberg,Daniel McCann,Manisha Desai,Michael Rosenbaum,Rudolph L. Leibel,Anthony W. Ferrante +5 more
TL;DR: Transcript expression in perigonadal adipose tissue from groups of mice in which adiposity varied due to sex, diet, and the obesity-related mutations agouti (Ay) and obese (Lepob) found that the expression of 1,304 transcripts correlated significantly with body mass.
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Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance.
Haiyan Xu,Glenn Barnes,Qing Yang,Guo Tan,Daseng Yang,Chieh J. Chou,Jason Sole,Andrew Nichols,Jeffrey S. Ross,Louis A. Tartaglia,Hong Chen +10 more
TL;DR: It is proposed that obesity-related insulin resistance is, at least in part, a chronic inflammatory disease initiated in adipose tissue, and that macrophage-related inflammatory activities may contribute to the pathogenesis of obesity-induced insulin resistance.
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Obesity-induced inflammatory changes in adipose tissue
TL;DR: This issue of the JCI reports that obese adipose tissue is characterized by macrophage infiltration and that these macrophages are an important source of inflammation in this tissue.
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Comparison of the Release of Adipokines by Adipose Tissue, Adipose Tissue Matrix, and Adipocytes from Visceral and Subcutaneous Abdominal Adipose Tissues of Obese Humans
TL;DR: The purpose of this study was to examine the source of adipokines released by the visceral and sc adipose tissues of obese humans and found that most of the adipokine release by the nonfat cells of adipose tissue was due to cells retained in the tissue matrix after collagenase digestion.
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Preadipocyte Conversion to Macrophage EVIDENCE OF PLASTICITY
Guillaume M. Charrière,Béatrice Cousin,Emmanuelle Arnaud,Mireille André,Francis Bacou,Luc Pénicaud,Louis Casteilla +6 more
TL;DR: The results suggest that preadipocytes have the potential to be very efficiently and rapidly converted into macrophages and reinforces the link between adipose tissue and innate immunity processes.