Adult stem cell niches for tissue homeostasis.
Giuliana Mannino,Cristina Russo,Grazia Maugeri,Giuseppe Musumeci,Nunzio Vicario,Daniele Tibullo,Rosario Giuffrida,Rosalba Parenti,Debora Lo Furno +8 more
TLDR
In this article, the authors describe the main characteristics of stem cell niches in these different tissues, highlighting the various components influencing stem cell activity, including stem cell-intrinsic factors, supporting cells, extracellular matrix, and signaling pathways.Abstract:
Adult stem cells are fundamental to maintain tissue homeostasis, growth, and regeneration. They reside in specialized environments called niches. Following activating signals, they proliferate and differentiate into functional cells that are able to preserve tissue physiology, either to guarantee normal turnover or to counteract tissue damage caused by injury or disease. Multiple interactions occur within the niche between stem cell-intrinsic factors, supporting cells, the extracellular matrix, and signaling pathways. Altogether, these interactions govern cell fate, preserving the stem cell pool, and regulating stem cell proliferation and differentiation. Based on their response to body needs, tissues can be largely classified into three main categories: tissues that even in normal conditions are characterized by an impressive turnover to replace rapidly exhausting cells (blood, epidermis, or intestinal epithelium); tissues that normally require only a basal cell replacement, though able to efficiently respond to increased tissue needs, injury, or disease (skeletal muscle); tissues that are equipped with less powerful stem cell niches, whose repairing ability is not able to overcome severe damage (heart or nervous tissue). The purpose of this review is to describe the main characteristics of stem cell niches in these different tissues, highlighting the various components influencing stem cell activity. Although much has been done, more work is needed to further increase our knowledge of niche interactions. This would be important not only to shed light on this fundamental chapter of human physiology but also to help the development of cell-based strategies for clinical therapeutic applications, especially when other approaches fail.read more
Citations
More filters
Journal ArticleDOI
Stem cell-based therapy for human diseases
Duc Manh Hoang,Phuong Tran Pham,T. Q. Bach,Anh T L Ngo,Q. T. Nguyen,Trang Phan,Giang H. Nguyen,Phuong T. Le,Van T. Hoang,Nicholas R. Forsyth,Michael Heke,Liem T. Nguyen +11 more
TL;DR: In this article , a review provides an update on recent clinical applications using either human pluripotent stem cells (hPSCs) or MSCs derived from bone marrow (BM), adipose tissue (AT), or the umbilical cord (UC) for the treatment of human diseases, including neurological disorders, pulmonary dysfunctions, metabolic/endocrine-related diseases, reproductive disorders, skin burns, and cardiovascular conditions.
Journal ArticleDOI
The Role of Epigenetics in Neuroinflammatory-Driven Diseases
Sebastiano Giallongo,Lucia Longhitano,Simona Denaro,Simona D’Aprile,Filippo Torrisi,E. La Spina,Cesarina Giallongo,Giuliana Mannino,Debora Lo Furno,Agata Zappalà,Rosario Giuffrida,Rosalba Parenti,Giovanni Li Volti,Daniele Tibullo,Nunzio Vicario +14 more
TL;DR: A review of the current knowledge on this field is presented in this paper , where deep changes in DNA and histone methylation, along with histone acetylation and altered non-coding RNA expression, have been reported at the onset of inflammatory diseases.
Journal ArticleDOI
The Microenvironment That Regulates Vascular Wall Stem/Progenitor Cells in Vascular Injury and Repair
TL;DR: This review underscores the microenvironment-derived signals that regulate VW-S/PCs and aims at providing new targets for the treatment of related cardiovascular diseases.
Journal ArticleDOI
Lactate Rewrites the Metabolic Reprogramming of Uveal Melanoma Cells and Induces Quiescence Phenotype
Lucia Longhitano,Sebastiano Giallongo,Laura Orlando,Giuseppe Broggi,Antonio Longo,Andrea Russo,Rosario Caltabiano,Cesarina Giallongo,Ignazio Barbagallo,Michelino Di Rosa,Rosario Giuffrida,Rosalba Parenti,Giovanni Li Volti,Nunzio Vicario,Daniele Tibullo +14 more
TL;DR: In this paper , the role of the oncometabolite lactate has become attractive due to its role as hydroxycarboxylic acid receptor 1 (HCAR1) activator, as an epigenetic modulator inducing lysine residues lactylation and, of course, as a glycolysis end-product, bridging the gap between glyco-lysis and oxidative phosphorylation.
Journal ArticleDOI
Telocytes inside of the peripheral nervous system – a 3D endoneurial network and putative role in cell communication
TL;DR: In this paper , the authors developed the hypothesis concerning the reasons to assimilate endoneurial fibroblast-like dendritic phenotype to the endoneural telocytes (TCs).
References
More filters
Journal ArticleDOI
Identification of stem cells in small intestine and colon by marker gene Lgr5
Nick Barker,Johan H. van Es,Jeroen Kuipers,Pekka Kujala,Maaike van den Born,Miranda Cozijnsen,Andrea Haegebarth,Jeroen Korving,Harry Begthel,Peter J. Peters,Hans Clevers +10 more
TL;DR: The expression pattern of Lgr5 suggests that it marks stem cells in multiple adult tissues and cancers, suggesting that it represents the stem cell of the small intestine and colon.
Journal ArticleDOI
Marrow Stromal Cells as Stem Cells for Nonhematopoietic Tissues
TL;DR: Marrow stromal cells present an intriguing model for examining the differentiation of stem cells and have several characteristics that make them potentially useful for cell and gene therapy.
Journal ArticleDOI
Adult Cardiac Stem Cells Are Multipotent and Support Myocardial Regeneration
Antonio Paolo Beltrami,Laura Barlucchi,Daniele Torella,Mathue Baker,Federica Limana,Stefano Chimenti,Hideko Kasahara,Marcello Rota,Ezio Musso,Konrad Urbanek,Annarosa Leri,Jan Kajstura,Bernardo Nadal-Ginard,Piero Anversa +13 more
TL;DR: The existence of Lin(-) c-kit(POS) cells with the properties of cardiac stem cells, which are self-renewing, clonogenic, and multipotent, giving rise to myocytes, smooth muscle, and endothelial cells are reported.
Journal ArticleDOI
Satellite cell of skeletal muscle fibers.
TL;DR: In the course of an electron microscopic study of the peripheral region of the skeletal muscle fiber of the frog, the presence of certain cells, intimately associated with the muscle fiber, have been observed which the authors have chosen to call satellite cells.
Journal ArticleDOI
Mesenchymal and haematopoietic stem cells form a unique bone marrow niche
Simón Méndez-Ferrer,Tatyana V. Michurina,Francesca Ferraro,Amin R. Mazloom,Ben D. MacArthur,Ben D. MacArthur,Sergio A. Lira,David T. Scadden,Avi Ma'ayan,Grigori Enikolopov,Paul S. Frenette,Paul S. Frenette +11 more
TL;DR: It is demonstrated that mesenchymal stem cells (MSCs), identified using nestin expression, constitute an essential HSC niche component and are indicative of a unique niche in the bone marrow made of heterotypic stem-cell pairs.