Aggressive Behavior and Altered Amounts of Brain Serotonin and Norepinephrine in Mice Lacking MAOA
Olivier Cases,Isabelle Seif,Joseph Grimsby,Patricia Gaspar,Kevin Chen,Sandrine Pournin,Ulrike Müller,Michel Aguet,Charles Babinet,Jean C. Shih,Edward De Maeyer +10 more
TLDR
Pup behavioral alterations, including trembling, difficulty in righting, and fearfulness were reversed by the serotonin synthesis inhibitor parachlorophenylalanine, and adults manifested a distinct behavioral syndrome, including enhanced aggression in males.Abstract:
Deficiency in monoamine oxidase A (MAOA), an enzyme that degrades serotonin and norepinephrine, has recently been shown to be associated with aggressive behavior in men of a Dutch family. A line of transgenic mice was isolated in which transgene integration caused a deletion in the gene encoding MAOA, providing an animal model of MAOA deficiency. In pup brains, serotonin concentrations were increased up to ninefold, and serotonin-like immunoreactivity was present in catecholaminergic neurons. In pup and adult brains, norepinephrine concentrations were increased up to twofold, and cytoarchitectural changes were observed in the somatosensory cortex. Pup behavioral alterations, including trembling, difficulty in righting, and fearfulness were reversed by the serotonin synthesis inhibitor parachlorophenylalanine. Adults manifested a distinct behavioral syndrome, including enhanced aggression in males.read more
Citations
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Changes in the Expression of Monoaminergic Genes under the Influence of Repeated Experience of Agonistic Interactions: From Behavior to Gene
Natalia N. Kudryavtseva,Maksim L. Filipenko,I. V. Bakshtanovskaya,Damira F. Avgustinovich,O. V. Alekseenko,A. G. Beilina +5 more
TL;DR: Repeated experience of social defeats produced dynamic changes in the serotonergic system of some brain areas and an increase of the mRNA level of the serotonin transporter and monoamine oxidase A genes in the midbrain raphe nuclei.
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A functional polymorphism in the promoter of monoamine oxidase A gene and bipolar affective disorder.
TL;DR: It is found that none of the different repeat copies was preferentially transmitted from mothers to their children affected with bipolar disorder and a non-significant trend for patients with an ultra-rapid cycling form of illness to have a higher frequency of low-activity alleles is found.
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How Monoamine Oxidase A Decomposes Serotonin: An Empirical Valence Bond Simulation of the Reactive Step
TL;DR: The quantum mechanics/molecular mechanics simulation of the rate-limiting step for the serotonin decomposition, which consists of hydride transfer from the serotonin methylene group to the N5 atom of the flavin moiety, provides strong evidence for the validity of the proposedhydride-transfer mechanism.
Book ChapterDOI
Monoamine oxidases: from brain maps to physiology and transgenics to pathophysiology.
J. G. Richards,Josep Saura,J.M. Luque,Cesura Andrea,J. Gottowik,P. Malherbe,Edilio Borroni,J. Gray +7 more
TL;DR: Recent advances in mapping the cellular sites of synthesis and catalytic activity, as well as age- and disease-related changes of monoamine oxidases A and B in the brain are reviewed.
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Aggressive behavior: A comprehensive review of its neurochemical mechanisms and management
TL;DR: Aggression is a deliberate series of actions that lead to harm, injury, or destruction of another organism, and is the most common factor promoting violent crimes as mentioned in this paper, however, when offenders appear normal or healthy, their most likely fate is punishment by the law.
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