Aggressive Behavior and Altered Amounts of Brain Serotonin and Norepinephrine in Mice Lacking MAOA
Olivier Cases,Isabelle Seif,Joseph Grimsby,Patricia Gaspar,Kevin Chen,Sandrine Pournin,Ulrike Müller,Michel Aguet,Charles Babinet,Jean C. Shih,Edward De Maeyer +10 more
TLDR
Pup behavioral alterations, including trembling, difficulty in righting, and fearfulness were reversed by the serotonin synthesis inhibitor parachlorophenylalanine, and adults manifested a distinct behavioral syndrome, including enhanced aggression in males.Abstract:
Deficiency in monoamine oxidase A (MAOA), an enzyme that degrades serotonin and norepinephrine, has recently been shown to be associated with aggressive behavior in men of a Dutch family. A line of transgenic mice was isolated in which transgene integration caused a deletion in the gene encoding MAOA, providing an animal model of MAOA deficiency. In pup brains, serotonin concentrations were increased up to ninefold, and serotonin-like immunoreactivity was present in catecholaminergic neurons. In pup and adult brains, norepinephrine concentrations were increased up to twofold, and cytoarchitectural changes were observed in the somatosensory cortex. Pup behavioral alterations, including trembling, difficulty in righting, and fearfulness were reversed by the serotonin synthesis inhibitor parachlorophenylalanine. Adults manifested a distinct behavioral syndrome, including enhanced aggression in males.read more
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Monoamine oxidase A activity and norepinephrine level in hippocampus determine hyperwheel running in SPORTS rats.
Masaki Morishima,Nagakatsu Harada,Sayuri Hara,Atsuko Sano,Hiromasa Seno,Akira Takahashi,Yusuke Morita,Yutaka Nakaya +7 more
TL;DR: Results indicate that decreased MAOA activity, elevation of extracellular NE, and α2-adrenergic receptors in the hippocampus determine the neural basis of the psychological regulation of exercise behavior in SPORTS rats.
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The role of MAO in personality and drug use.
Jaanus Harro,Lars Oreland +1 more
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Transcriptome analysis of genes and gene networks involved in aggressive behavior in mouse and zebrafish
Karim Malki,Ebba Du Rietz,Wim E. Crusio,Oliver Pain,Jose L. Paya-Cano,Rezhaw L. Karadaghi,Frans Sluyter,Sietse F. de Boer,Kenneth Sandnabba,Leonard C. Schalkwyk,Philip Asherson,Maria Grazia Tosto +11 more
TL;DR: This study compared gene expression profiles from a genetic mouse model of aggression with zebrafish, an animal model traditionally used to study aggression, to uncover genes consistently implicated in aggression across both studies.
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