Aggressive Behavior and Altered Amounts of Brain Serotonin and Norepinephrine in Mice Lacking MAOA
Olivier Cases,Isabelle Seif,Joseph Grimsby,Patricia Gaspar,Kevin Chen,Sandrine Pournin,Ulrike Müller,Michel Aguet,Charles Babinet,Jean C. Shih,Edward De Maeyer +10 more
TLDR
Pup behavioral alterations, including trembling, difficulty in righting, and fearfulness were reversed by the serotonin synthesis inhibitor parachlorophenylalanine, and adults manifested a distinct behavioral syndrome, including enhanced aggression in males.Abstract:
Deficiency in monoamine oxidase A (MAOA), an enzyme that degrades serotonin and norepinephrine, has recently been shown to be associated with aggressive behavior in men of a Dutch family. A line of transgenic mice was isolated in which transgene integration caused a deletion in the gene encoding MAOA, providing an animal model of MAOA deficiency. In pup brains, serotonin concentrations were increased up to ninefold, and serotonin-like immunoreactivity was present in catecholaminergic neurons. In pup and adult brains, norepinephrine concentrations were increased up to twofold, and cytoarchitectural changes were observed in the somatosensory cortex. Pup behavioral alterations, including trembling, difficulty in righting, and fearfulness were reversed by the serotonin synthesis inhibitor parachlorophenylalanine. Adults manifested a distinct behavioral syndrome, including enhanced aggression in males.read more
Citations
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Effect of Monoamine Oxidase Gene Knockout on Dopamine Metabolism in Mouse Brain Structures
Nina K. Popova,Nina K. Popova,M. A. Gilinskii,M. A. Gilinskii,Tamara G. Amstislavskaya,Tamara G. Amstislavskaya +5 more
TL;DR: The results suggest that monoamine oxidases A and B and catechol-O-methyltransferase play different roles in dopamine metabolism in various brain structures.
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MAOA variants differ in oscillatory EEG & ECG activities in response to aggression-inducing stimuli
Seung Yeong Im,Jinju Jeong,Gwonhyu Jin,Jiwoo Yeom,Janghwan Jekal,Sang-im Lee,Jung Ah Cho,Sukkyoo Lee,Youngmi Lee,Dae-Hwan Kim,Mijeong Bae,Jinhwa Heo,Cheil Moon,Chang-Hun Lee +13 more
TL;DR: The electroencephalogram and electrocardiogram results obtained under aggression-related stimulation revealed oscillatory changes as novel phenotypes that vary with the MAOA genotype, providing genetic insights into MAOA function and offer a neurobiological basis for various socio-emotional mechanisms in healthy individuals.
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Behavior and gene expression in the brain of adult self-fertilizing mangrove rivulus fish (Kryptolebias marmoratus) after early life exposure to the neurotoxin β-N-methylamino-l-alanine (BMAA)
Alessandra Carion,Angèle Markey,Julie Hétru,Camille Carpentier,Victoria Suarez-Ulloa,Mathieu Denoël,Ryan L. Earley,Frédéric Silvestre +7 more
TL;DR: It is revealed that BMAA can have long-lasting effects on the brain that are suspected to affect phenotypic traits with aging and highlights the importance of studying delayed effects in ecotoxicological studies.
Roles of forced nicotine exposure and Comt gene disruption in the development of addiction-related behavioural and neurochemical changes in mice
TL;DR: In this article, the authors propose a solution to solve the problem of concurrence of the 2.7.7 dB.0 dB.1 dB.2 dB.5 dB.
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Interactions between MAOA and SYP polymorphisms were associated with symptoms of attention-deficit/hyperactivity disorder in Chinese Han subjects
TL;DR: It is suggested that the interaction of MAOA and SYP may be involved in the genetic mechanism of ADHD‐I subtype and predict ADHD symptoms.
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