Aggressive Behavior and Altered Amounts of Brain Serotonin and Norepinephrine in Mice Lacking MAOA
Olivier Cases,Isabelle Seif,Joseph Grimsby,Patricia Gaspar,Kevin Chen,Sandrine Pournin,Ulrike Müller,Michel Aguet,Charles Babinet,Jean C. Shih,Edward De Maeyer +10 more
TLDR
Pup behavioral alterations, including trembling, difficulty in righting, and fearfulness were reversed by the serotonin synthesis inhibitor parachlorophenylalanine, and adults manifested a distinct behavioral syndrome, including enhanced aggression in males.Abstract:
Deficiency in monoamine oxidase A (MAOA), an enzyme that degrades serotonin and norepinephrine, has recently been shown to be associated with aggressive behavior in men of a Dutch family. A line of transgenic mice was isolated in which transgene integration caused a deletion in the gene encoding MAOA, providing an animal model of MAOA deficiency. In pup brains, serotonin concentrations were increased up to ninefold, and serotonin-like immunoreactivity was present in catecholaminergic neurons. In pup and adult brains, norepinephrine concentrations were increased up to twofold, and cytoarchitectural changes were observed in the somatosensory cortex. Pup behavioral alterations, including trembling, difficulty in righting, and fearfulness were reversed by the serotonin synthesis inhibitor parachlorophenylalanine. Adults manifested a distinct behavioral syndrome, including enhanced aggression in males.read more
Citations
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Toward a molecular architecture of personality.
Andreas Reif,Klaus-Peter Lesch +1 more
TL;DR: The findings converge on the notion that a probabilistic rather than deterministic impact of genes on the expression of behavior will contribute to the demystification of behavioral disorders.
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Reduced aggression in mice lacking the serotonin transporter.
TL;DR: Dysregulation of the brain serotonergic system has been implicated in the pathophysiology of violence and aggression and desensitization of 5-HT1A/1B receptor function may contribute to reduced aggression in 5- HTT KO mice.
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Serotonin, social status and aggression
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Monoamine oxidase A gene promoter variation and rearing experience influences aggressive behavior in rhesus monkeys
Timothy K. Newman,Yana V. Syagailo,Christina S. Barr,Jens R. Wendland,Maribeth Champoux,Markus Graessle,Stephen J. Suomi,J. Dee Higley,Klaus-Peter Lesch +8 more
TL;DR: The results suggest that the behavioral expression of allelic variation in MAOA activity is sensitive to social experiences early in development and that its functional outcome might depend on social context.
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An association between a functional polymorphism in the monoamine oxidase a gene promoter, impulsive traits and early abuse experiences.
Yung-yu Huang,Sarah P Cate,Cristina Battistuzzi,Maria A. Oquendo,David A. Brent,J. John Mann +5 more
TL;DR: The results suggest that the lower expression of the MAOA-uVNTR polymorphism is related to a history of early Abuse and may sensitize males, but not females, to the effects of early abuse experiences on impulsive traits in adulthood.
References
More filters
Journal Article
Behavioral despair in mice: a primary screening test for antidepressants
Porsolt Rd,Bertin A,Jalfre M +2 more
TL;DR: The mouse procedure is more rapid and less costly than that with rats and is thus more suitable for the primary screening of antidepressant drugs, suggesting that the procedure is selectively sensitive to antidepressant treatments.
Journal ArticleDOI
Functional role of type I and type II interferons in antiviral defense.
Ulrike Müller,Ulrich Steinhoff,Luiz F. L. Reis,Silvio Hemmi,Jovan Pavlovic,Rolf M. Zinkernagel,Michel Aguet +6 more
TL;DR: Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant.
Journal ArticleDOI
The structural organization of layer IV in the somatosensory region (SI) of mouse cerebral cortex. The description of a cortical field composed of discrete cytoarchitectonic units.
TL;DR: The author describes how his methods of investigation with celloidin embedded material prepared with the Golgi method and Nissl staining revealed for the first time the “barrel fields” of the mouse cerebral cortex that are activated by stimulation of the facial vibrissae (whiskers).
Journal ArticleDOI
Genetic Applications of an Inverse Polymerase Chain Reaction
TL;DR: The feasibility of IPCR is shown by amplifying the sequences that flank an IS1 element in the genome of a natural isolate of Escherichia coli.
Journal ArticleDOI
Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A
TL;DR: Analytical results indicate that isolated complete MAOA deficiency in this family is associated with a recognizable behavioral phenotype that includes disturbed regulation of impulsive aggression.