Aggressive Behavior and Altered Amounts of Brain Serotonin and Norepinephrine in Mice Lacking MAOA
Olivier Cases,Isabelle Seif,Joseph Grimsby,Patricia Gaspar,Kevin Chen,Sandrine Pournin,Ulrike Müller,Michel Aguet,Charles Babinet,Jean C. Shih,Edward De Maeyer +10 more
TLDR
Pup behavioral alterations, including trembling, difficulty in righting, and fearfulness were reversed by the serotonin synthesis inhibitor parachlorophenylalanine, and adults manifested a distinct behavioral syndrome, including enhanced aggression in males.Abstract:
Deficiency in monoamine oxidase A (MAOA), an enzyme that degrades serotonin and norepinephrine, has recently been shown to be associated with aggressive behavior in men of a Dutch family. A line of transgenic mice was isolated in which transgene integration caused a deletion in the gene encoding MAOA, providing an animal model of MAOA deficiency. In pup brains, serotonin concentrations were increased up to ninefold, and serotonin-like immunoreactivity was present in catecholaminergic neurons. In pup and adult brains, norepinephrine concentrations were increased up to twofold, and cytoarchitectural changes were observed in the somatosensory cortex. Pup behavioral alterations, including trembling, difficulty in righting, and fearfulness were reversed by the serotonin synthesis inhibitor parachlorophenylalanine. Adults manifested a distinct behavioral syndrome, including enhanced aggression in males.read more
Citations
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Suicidal behavior: relationship between phenotype and serotonergic genotype.
TL;DR: The basis of suicidal behavior (SB) is complex and multifactorial. Numerous risk factors have been identified. as discussed by the authors, including genetic factors that predispose individuals to disorders of complex etiology.
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Association analysis of the monoamine oxidase A and B genes with attention deficit hyperactivity disorder (ADHD) in an Irish sample: preferential transmission of the MAO-A 941G allele to affected children
Katharina Domschke,Karen Sheehan,N. Lowe,Aiveen Kirley,Celine Mullins,Roderick O'Sullivan,Christine M. Freitag,Tim Becker,Judith Conroy,Michael Fitzgerald,Michael Gill,Ziarih Hawi +11 more
TL;DR: The findings suggest the importance of the 941G/T MAO‐A polymorphism in the development of ADHD at least in the Irish population.
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Altered regulation of the 5-HT system in the brain of MAO-A knock-out mice.
Alexis Evrard,Isabelle Malagié,A. M. Laporte,Claudette Boni,Naïma Hanoun,Anne-Cécile Trillat,Isabelle Seif,E. De Maeyer,Alain M. Gardier,Michel Hamon,Joëlle Adrien +10 more
TL;DR: 5‐HT mechanisms in knock‐out mice (2‐month‐old) lacking MAO‐A are investigated, indicating that the enhancement of extracellular 5‐HT levels induces a down‐regulation of the 5‐ HT transporter, and a desensitization of 5-HT1A autoreceptors which allows the maintenance of tonic activity of 4‐HT neurons in the DRN.
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Cluster B personality disorders are associated with allelic variation of monoamine oxidase A activity.
Christian Jacob,Johannes Müller,Michael Schmidt,Katrin Hohenberger,Lise Gutknecht,Andreas Reif,Armin Schmidtke,Rainald Mössner,Klaus-Peter Lesch +8 more
TL;DR: The notion that allelic variation of MAOA activity contributes modestly to the balance of hyper- (impulsive-aggressive) and hyporeactive (anxious-depressive) traits is supported.
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