Journal ArticleDOI
Alopecia Universalis Associated with a Mutation in the Human hairless Gene
Wasim Ahmad,Muhammad Faiyaz ul Haque,Valeria Brancolini,Hui C. Tsou,Sayed ul Haque,HaMut Lam,Vincent M. Aita,Jason E. Owen,Michelle deBlaquiere,Jorge Frank,P. B. Cserhalmi-Friedman,Andrew Leask,John A. McGrath,Monica Peacocke,Mahmud Ahmad,Jurg Ott,Angela M. Christiano +16 more
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TLDR
A kindred with a rare, recessively inherited type of alopecia universalis was used to search for a locus by homozygosity mapping, and linkage was established in a 6-centimorgan interval on chromosome 8p12 (the logarithm of the odds favoring linkage score was 6.19 as discussed by the authors ).Abstract:
There are several forms of hereditary human hair loss, known collectively as alopecias, the molecular bases of which are entirely unknown. A kindred with a rare, recessively inherited type of alopecia universalis was used to search for a locus by homozygosity mapping, and linkage was established in a 6-centimorgan interval on chromosome 8p12 (the logarithm of the odds favoring linkage score was 6.19). The human homolog of a murine gene, hairless, was localized in this interval by radiation hybrid mapping, and a missense mutation was found in affected individuals. Human hairless encodes a putative single zinc finger transcription factor protein with restricted expression in the brain and skin.read more
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Controls of hair follicle cycling.
Kurt S. Stenn,Ralf Paus +1 more
TL;DR: This review has used Chase as the model and tried to put the adult hair follicle growth cycle in perspective, and hopes that this work will serve as an introduction to basic biologists who are looking for a defined biological system that illustrates many of the challenges of modern biology.
Journal ArticleDOI
The biology of hair follicles.
Ralf Paus,George Cotsarelis +1 more
TL;DR: Progress in understanding of the biology and pathology of hair follicles should lead to more effective therapies for disorders of hair growth, and few drugs that are effective for these purposes are available.
Journal ArticleDOI
JmjC-domain-containing proteins and histone demethylation.
TL;DR: The evolutionary relationship between Jumonji C (JmjC)-domain-containing proteins is analysed and their cellular functions in relation to their potential enzymatic activities are discussed.
Journal ArticleDOI
Nonclassic Actions of Vitamin D
TL;DR: The nonclassic actions of vitamin D are cell specific and provide a number of potential new clinical applications for 1,25(OH)(2)D(3) and its analogs, however, the use ofitamin D metabolites and analogs for these applications remains limited by the classic actions of Vitamin D leading to hypercalcemia and hypercalcuria.
Journal ArticleDOI
Molecular mechanisms regulating hair follicle development.
TL;DR: This review is to summarize recent progress in the understanding of the molecular mechanisms regulating hair follicle formation, and to discuss ways in which this information may eventually be utilized in the clinic.
References
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Book
Molecular Cloning: A Laboratory Manual
TL;DR: Molecular Cloning has served as the foundation of technical expertise in labs worldwide for 30 years as mentioned in this paper and has been so popular, or so influential, that no other manual has been more widely used and influential.
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The secret life of the hair follicle
TL;DR: There is now evidence that several growth factors, cell adhesion molecules and other molecules play important roles in the regulation of this minute organ.
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Mouse GATA-4: a retinoic acid-inducible GATA-binding transcription factor expressed in endodermally derived tissues and heart.
TL;DR: It is concluded that GATA-4 is a tissue-specific, retinoic acid-inducible, and developmentally regulated transcription factor that plays a role in gene expression in the heart, intestinal epithelium, primitive endoderm, and gonads.
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Conformation-sensitive gel electrophoresis for rapid detection of single-base differences in double-stranded PCR products and DNA fragments: evidence for solvent-induced bends in DNA heteroduplexes
TL;DR: The hypothesis that an appropriate system of mildly denaturing solvents can amplify the tendency of single-base mismatches to produce conformational changes, such as bends in the double helix, and thereby increase the differential migration of DNA heterod uplexes and homoduplexes during gel electrophoresis is tested.
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New member of the winged-helix protein family disrupted in mouse and rat nude mutations
TL;DR: The whn gene, designated whn, encodes a new member of the winged-helix domain family of transcription factors and is disrupted on mouse nu and rat rnuN alleles, the first member of this class of genes to be implicated in a specific developmental defect in vertebrates.