Journal ArticleDOI
AMPK and its Activator Berberine in the Treatment of Neurodegenerative Diseases.
Siru Qin,Huiling Tang,Wei Li,Yinan Gong,Shanshan Li,Jin Huang,Yuxin Fang,Wenjuan Yuan,Yangyang Liu,Shenjun Wang,Yongming Guo,Yi Guo,Zhifang Xu +12 more
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TLDR
The energy sensor adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK) and its agonist berberine can combat the common underlying pathological events of neurodegeneration including oxidative stress, neuroinflammation, mitochondrial disorder, glutamate excitotoxicity, apoptosis, autophagy disorder and neurovascular units disruption.Abstract:
Neurodegenerative disorders are heterogeneous diseases associated with either acute or progressive neurodegeneration, causing the loss of neurons and axons in the central nervous system (CNS), showing high morbidity and mortality, and there are only a few effective therapies. Here, we summarized that the energy sensor adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK), and its agonist berberine can combat the common underlying pathological events of neurodegeneration, including oxidative stress, neuroinflammation, mitochondrial disorder, glutamate excitotoxicity, apoptosis, autophagy disorder, and disruption of neurovascular units. The abovementioned effects of berberine may primarily depend on activating AMPK and its downstream targets, such as the mammalian target of rapamycin (mTOR), sirtuin1 (SIRT1), nuclear factor erythroid-2 related factor-2 (Nrf2), nuclear factor-κB (NF-κB), phosphoinositide 3-kinase/protein kinase B (PI3K/Akt), nicotinamide adenine dinucleotide (NAD+), and p38 mitogen-activated protein kinase (p38 MAPK). It is hoped that this review will provide a strong basis for further scientific exploration and development of berberine's therapeutic potential against neurodegeneration.read more
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Merging the Multi-Target Effects of Phytochemicals in Neurodegeneration: From Oxidative Stress to Protein Aggregation and Inflammation.
Fiona Limanaqi,Francesca Biagioni,Federica Mastroiacovo,Maico Polzella,Gloria Lazzeri,Francesco Fornai +5 more
TL;DR: The present review focuses on some popular phytochemical classes and bioactive compounds as representative examples to design a sort of main highway aimed at deciphering the most relevant protective mechanisms which make phytochemicals potentially useful in counteracting neurodegeneration.
Journal ArticleDOI
Efficacy of berberine in treatment of rheumatoid arthritis: From multiple targets to therapeutic potential.
TL;DR: In this article, a review of the therapeutic potential of BBR and its mechanism of action in ameliorating RA, and discuss the modulation of gut microbiota by BBR during RA.
Journal ArticleDOI
Neuroprotective effects of liraglutide against inflammation through the AMPK/NF-κB pathway in a mouse model of Parkinson's disease.
TL;DR: In this paper, the effect of liraglutide on 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP)-induced injury in mice and its potential mechanism of action was examined.
Journal ArticleDOI
Beneficial Effects of Metformin on the Central Nervous System, with a Focus on Epilepsy and Lafora Disease.
TL;DR: The beneficial effects of this drug as a neuroprotective agent in different neurological diseases, with a special focus on epileptic disorders and Lafora disease, a particular type of progressive myoclonus epilepsy are reviewed.
Journal ArticleDOI
Berberine ameliorates nonalcoholic fatty liver disease by decreasing the liver lipid content via reversing the abnormal expression of MTTP and LDLR
Ping Chen,Yusheng Li,Li Xiao +2 more
TL;DR: In this paper, the effect and mechanism of berberine (BBR) on NAFLD in rats was explored, which showed that BBR treatment ameliorated the fatty liver induced by a high-fat diet in rats.
References
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