Journal ArticleDOI
Efficacy of berberine in treatment of rheumatoid arthritis: From multiple targets to therapeutic potential.
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TLDR
In this article, a review of the therapeutic potential of BBR and its mechanism of action in ameliorating RA, and discuss the modulation of gut microbiota by BBR during RA.About:
This article is published in Pharmacological Research.The article was published on 2021-05-11. It has received 18 citations till now.read more
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Targeting inflammation and redox aberrations by perindopril attenuates methotrexate-induced intestinal injury in rats: Role of TLR4/NF-κB and c-Fos/c-Jun pro-inflammatory pathways and PPAR-γ/SIRT1 cytoprotective signals
TL;DR: Perindopril attenuated the intestinal injury as seen by lowering the histopathological aberrations and preserving the goblet cells in villi/crypts in rats as discussed by the authors .
Journal ArticleDOI
Targeting inflammation and redox aberrations by perindopril attenuates methotrexate-induced intestinal injury in rats: Role of TLR4/NF-κB and c-Fos/c-Jun pro-inflammatory pathways and PPAR-γ/SIRT1 cytoprotective signals.
TL;DR: In this article, perindopril attenuated the intestinal injury as seen by lowering the histopathological aberrations and preserving the goblet cells in villi/crypts.
Journal ArticleDOI
Clinical evidence construction of East Asian herbal medicine for inflammatory pain in rheumatoid arthritis based on integrative data mining approach
TL;DR: In this article , a systematic study of how EAHM treatments can be developed into new drugs using specific materials is needed, and a meta-analysis was performed on the variable data to assess their effects on inflammatory pain.
Journal ArticleDOI
Fengshi Qutong capsule ameliorates bone destruction of experimental rheumatoid arthritis by inhibiting osteoclastogenesis
TL;DR: Wang et al. as mentioned in this paper investigated the effect of Fengshi Qutong capsule (FSQTC) on bone destruction of rheumatoid arthritis and the possible mechanism of osteoclastogenesis in vivo and in vitro.
Journal ArticleDOI
Anti-inflammatory and immunomodulatory activity of Mangifera indica L. reveals the modulation of COX-2/mPGES-1 axis and Th17/Treg ratio.
Anella Saviano,Federica Raucci,Gian Marco Casillo,Adel Abo Mansour,Vincenzo Piccolo,Camilla Montesano,M. Smimmo,Valentina Vellecco,Gennaro Capasso,A. Boscaino,Vincenzo Summa,Nicola Mascolo,Asif J. Iqbal,Raffaella Sorrentino,Roberta d'Emmanuele di Villa Bianca,Mariarosaria Bucci,Vincenzo Brancaleone,Francesco Milone +17 more
TL;DR: In this paper , the potential beneficial effects of Mangifera indica extract (MIE, 90 % in mangiferin) in a mouse model of gouty arthritis, to allow the evaluation of cellular immune phenotypes and the biochemical mechanism/s beyond MIE activity was analyzed.
References
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Journal ArticleDOI
Host-Gut Microbiota Metabolic Interactions
Jeremy K. Nicholson,Elaine Holmes,James Kinross,Rémy Burcelin,Glenn R. Gibson,Wei Jia,Sven Pettersson +6 more
TL;DR: A deeper understanding of the axes that physiologically connect the gut, liver, muscle, and brain are a prerequisite for optimizing therapeutic strategies to manipulate the gut microbiota to combat disease and improve health.
Journal ArticleDOI
From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites
TL;DR: Data is reviewed supporting the diverse functional roles carried out by a major class of bacterial metabolites, the short-chain fatty acids (SCFAs), which affect various physiological processes and may contribute to health and disease.
Journal ArticleDOI
Fibroblast-like synoviocytes: key effector cells in rheumatoid arthritis
Beatrix Bartok,Gary S. Firestein +1 more
TL;DR: Rheumatoid FLS develop a unique aggressive phenotype that increases invasiveness into the extracellular matrix and further exacerbates joint damage, and new agents that target FLS could potentially complement the current therapies without major deleterious effect on adaptive immune responses.
Journal ArticleDOI
Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis
Jose U. Scher,Andrew Sczesnak,Andrew Sczesnak,Randy S. Longman,Randy S. Longman,Nicola Segata,Nicola Segata,Carles Ubeda,Carles Ubeda,Craig M. Bielski,Tim Rostron,Vincenzo Cerundolo,Eric G. Pamer,Steven B. Abramson,Curtis Huttenhower,Dan R. Littman +15 more
TL;DR: The presence of Prevotella copri is identified as strongly correlated with disease in new-onset untreated rheumatoid arthritis (NORA) patients and uniquePrevotella genes that correlate with disease are identified.
Journal ArticleDOI
T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-gamma.
Hiroshi Takayanagi,Kouetsu Ogasawara,Shigeaki Hida,Tomoki Chiba,Shigeo Murata,Kojiro Sato,Akinori Takaoka,Taeko Yokochi,Hiromi Oda,Keiji Tanaka,Kozo Nakamura,Tadatsugu Taniguchi +11 more
TL;DR: This study shows that there is cross-talk between the tumour necrosis factor and IFN families of cytokines, through which IFN-γ provides a negative link between T-cell activation and bone resorption and may offer a therapeutic approach to treat the inflammation-induced tissue breakdown.