AMPK in myocardial infarction and diabetes: the yin/yang effect
Amr Moussa,Ji Li +1 more
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TLDR
Understanding so far of the role of AMPK in coordinating the cellular response to ischemic stress and reperfusion injury in the heart is summarized and a focused update on the pharmacological agents activating AMPK for treatment of diabetes that show potential cardioprotective effects is provided.About:
This article is published in Acta Pharmaceutica Sinica B.The article was published on 2012-08-01 and is currently open access. It has received 25 citations till now. The article focuses on the topics: AMPK.read more
Citations
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Journal ArticleDOI
The Role of AMPK Activation for Cardioprotection in Doxorubicin-Induced Cardiotoxicity.
Kerstin N. Timm,Damian J. Tyler +1 more
TL;DR: Different agents known to activate AMPK (metformin, statins, resveratrol, thiazolidinediones, AICAR, specific AMPK activators) as well as exercise and dietary restriction are introduced and the existing evidence for their potential role in cardioprotection from doxorubicin cardiotoxicity is discussed.
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Antithrombin up-regulates AMP-activated protein kinase signalling during myocardial ischaemia/reperfusion injury
Yina Ma,Jinli Wang,Junjie Gao,Hui Yang,Yanqing Wang,Chandrashekhara Manithody,Ji Li,Alireza R. Rezaie +7 more
TL;DR: It is suggested that AT binds to HSPGs on heart tissues to invoke a cardioprotective function by triggering cardiac AMPK activation, thereby attenuating JNK inflammatory signalling pathways and modulating substrate metabolism during I/R.
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Antidiabetic effects of flavonoids from Sophora flavescens EtOAc extract in type 2 diabetic KK-ay mice
Xinzhou Yang,Xinzhou Yang,Jing Yang,Chan Xu,Mi Huang,Qi Zhou,Jingnan Lv,Xinhua Ma,Chang-Qiang Ke,Yang Ye,Guangwen Shu,Ping Zhao +11 more
TL;DR: According to the results of the present study, SF-EtOAc possesses a potent antidiabetic activity and could be used as a safe remedy for the treatment of diabetes.
Journal ArticleDOI
Cardiac-Specific Deletion of the Pdha1 Gene Sensitizes Heart to Toxicological Actions of Ischemic Stress
Wanqing Sun,Nanhu Quan,Nanhu Quan,Lin Wang,Lin Wang,Hui Yang,Dongyang Chu,Quan Liu,Xuezhong Zhao,Jiyan Leng,Ji Li +10 more
TL;DR: Immunoblotting results demonstrated that cardiac PDH E1α deficiency leads to an impaired ischemic AMP-activated protein kinase activation through Sestrin2-liver kinase B1 interaction which is responsible for an increased susceptibility of PDHE1α-deficient heart to isChemic insults.
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Natural antioxidant-isoliquiritigenin ameliorates contractile dysfunction of hypoxic cardiomyocytes via AMPK signaling pathway.
Xiao-Yu Zhang,Xiao-Yu Zhang,Ping Zhu,Xiuying Zhang,Yina Ma,Wen-Guang Li,Jimei Chen,Huiming Guo,Richard Bucala,Jian Zhuang,Ji Li +10 more
TL;DR: The results demonstrated that ISL treatment markedly ameliorated cardiomyocytes contractile dysfunction caused by hypoxia and demonstrated the cardioprotection against ischemic injury that may attribute to the activation of AMPK and ERK signaling pathways and balance of cellular redox status.
References
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Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium.
TL;DR: The multiple anginal episodes that often precede myocardial infarction in man may delay cell death after coronary occlusion, and thereby allow for greater salvage of myocardium through reperfusion therapy, which is proposed to protect the heart from a subsequent sustained ischemic insult.
Journal Article
MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20536 high-risk individuals: a randomised placebo-controlled trial. Commentary
TL;DR: Adding simvastatin to existing treatments safely produces substantial additional benefits for a wide range of high-risk patients, irrespective of their initial cholesterol concentrations.
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AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
TL;DR: A molecular mechanism for regulation of the mammalian autophagy-initiating kinase Ulk1, a homologue of yeast ATG1, is demonstrated and a signalling mechanism for UlK1 regulation and autophagic induction in response to nutrient signalling is revealed.
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Role of AMP-activated protein kinase in mechanism of metformin action
Gaochao Zhou,Robert W. Myers,Ying Li,Yuli Chen,Xiaolan Shen,Judy Fenyk-Melody,Margaret Wu,John Ventre,Thomas W. Doebber,Nobuharu Fujii,Nicolas Musi,Michael F. Hirshman,Laurie J. Goodyear,David E. Moller +13 more
TL;DR: It is reported that metformin activates AMPK in hepatocytes; as a result, acetyl-CoA carboxylase (ACC) activity is reduced, fatty acid oxidation is induced, and expression of lipogenic enzymes is suppressed.
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Effect of Rosiglitazone on the Risk of Myocardial Infarction and Death from Cardiovascular Causes
Steven E. Nissen,Kathy Wolski +1 more
TL;DR: Patients and providers should consider the potential for serious adverse cardiovascular effects of treatment with rosiglitazone for type 2 diabetes mellitus as well as the availability of outcome data for myocardial infarction and death from cardiovascular causes.