Open AccessJournal Article
An electron microscopic study of heme uptake by rat duodenum.
J C Wyllie,N Kaufman +1 more
Reads0
Chats0
TLDR
The uptake of heme by mucosal absorptive cells of rat duodenum was studied by electron microscopy and gradual loss, with time, of 3,3'-diaminobenzidine reaction product from secondary lysosomes indicated cleavage ofHeme therein.About:
This article is published in Laboratory Investigation.The article was published on 1982-11-01 and is currently open access. It has received 59 citations till now. The article focuses on the topics: Apical cytoplasm & Heme.read more
Citations
More filters
Journal ArticleDOI
Systemic iron homeostasis
TL;DR: This review summarizes and discusses recent progress in molecular characterization of systemic iron homeostasis and its disorders, and identifies areas for further investigation.
Journal ArticleDOI
Identification of an intestinal heme transporter.
M Shayeghi,Gladys O. Latunde-Dada,Jonathan S. Oakhill,Abas H. Laftah,Ken Takeuchi,Neil Halliday,Yasmin Khan,Alice Warley,Fiona E. McCann,Robert C. Hider,David M. Frazer,Gregory J. Anderson,Chris D. Vulpe,Robert J. Simpson,Andrew T. McKie +14 more
TL;DR: A membrane protein named HCP 1 (heme carrier protein 1), with homology to bacterial metal-tetracycline transporters, mediates heme uptake by cells in a temperature-dependent and saturable manner and is indicated to be the long-sought intestinal heme transporter.
Journal ArticleDOI
Iron absorption and transport: An update
Marcel E. Conrad,Jay N. Umbreit +1 more
TL;DR: SFT (Stimulator of Iron Transport) is postulated to facilitate both ferric and ferrous iron uptake, and Hephaestin is thought to be important in transfer of iron from enterocytes into the plasma, suggesting that these pathways have intracellular functions in addition to facilitating iron uptake.
Journal ArticleDOI
The role of transporters in cellular heme and porphyrin homeostasis
TL;DR: The roles of the recently identified heme/porphyrin transport proteins heme carrier protein 1 (HCP1), FLVCR, Abcg2 and Abcb6 are discussed and how these transporters contribute to intracellular heme and porphyrin homeostasis are discussed.
Journal ArticleDOI
Iron Absorption and Transport
TL;DR: Iron is vital for living organisms because it is essential for multiple metabolic processes to include oxygen transport, DNA synthesis, and electron transport, however, iron must be bound to proteins to prevent tissue damage from free radical formation and its concentrations in body organs must be regulated carefully.