An immune clock of human pregnancy.
Nima Aghaeepour,Edward A. Ganio,David R. McIlwain,Amy S. Tsai,Martha Tingle,Sofie Van Gassen,Dyani Gaudilliere,Quentin Baca,Leslie McNeil,Robin Okada,Mohammad Sajjad Ghaemi,David Furman,David Furman,Ronald J. Wong,Virginia D. Winn,Maurice L. Druzin,Yaser Y. El-Sayed,Cecele C. Quaintance,Ronald S. Gibbs,Gary L. Darmstadt,Gary M. Shaw,David K. Stevenson,Robert Tibshirani,Garry P. Nolan,David B. Lewis,Martin S. Angst,Brice Gaudilliere +26 more
TLDR
These findings unravel the precise timing of immunological events occurring during a term pregnancy and provide the analytical framework to identify immunological deviations implicated in pregnancy-related pathologies.Abstract:
The maintenance of pregnancy relies on finely tuned immune adaptations. We demonstrate that these adaptations are precisely timed, reflecting an immune clock of pregnancy in women delivering at term. Using mass cytometry, the abundance and functional responses of all major immune cell subsets were quantified in serial blood samples collected throughout pregnancy. Cell signaling-based Elastic Net, a regularized regression method adapted from the elastic net algorithm, was developed to infer and prospectively validate a predictive model of interrelated immune events that accurately captures the chronology of pregnancy. Model components highlighted existing knowledge and revealed previously unreported biology, including a critical role for the interleukin-2-dependent STAT5ab signaling pathway in modulating T cell function during pregnancy. These findings unravel the precise timing of immunological events occurring during a term pregnancy and provide the analytical framework to identify immunological deviations implicated in pregnancy-related pathologies.read more
Citations
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OUP accepted manuscript
TL;DR: In this article , the authors investigated the role of the immune system in female CoR using DNA methylation (DNAm) in a cross-sectional cohort of young (20-22 years old) women differing in reproductive status.
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Maternal metabolic profiling to assess fetal gestational age and predict preterm delivery: a two-centre retrospective cohort study in the US
Karl G. Sylvester,Shiying Hao,Jin You,Le Zheng,Lu Tian,Xiaoming Yao,Lihong Mo,Subhashini Ladella,Ronald J. Wong,Gary M. Shaw,David K. Stevenson,Harvey J. Cohen,John C. Whitin,Doff B. McElhinney,Xuefeng B. Ling +14 more
TL;DR: With additional patient validation studies, these algorithms may be used to identify at-risk pregnancies prompting alterations in clinical care, and to gain biological insights into the pathophysiology of preterm birth.
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Immune Regulation in Eutherian Pregnancy: Live Birth Coevolved with Novel Immune Genes and Gene Regulation
TL;DR: These three mechanisms (novel regulatory elements, novel immune genes, and trade-offs) played a pivotal role in refining the regulation of maternal immune systems during pregnancy in eutherians, likely facilitating the establishment of prolonged direct maternal-fetal contact in e Lutherians without causing immunological rejection of the genetically distinct fetus.
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Adaptation of Imaging Mass Cytometry to Explore the Single Cell Alloimmune Landscape of Liver Transplant Rejection
Nolan M. Ung,Cameron Goldbeck,Cassandra Man,Julianne Hoeflich,Ren Cheng Sun,Arianna Barbetta,Naim Matasci,J. I. Katz,Jerry S.H. Lee,Shefali Chopra,Shahab Asgharzadeh,M. Warren,Linda Sher,Rohit Kohli,Omid Akbari,Yuri Genyk,Juliet Emamaullee +16 more
TL;DR: The power of IMC to investigate the alloimmune microenvironment at a single cell resolution during clinical rejection episodes is highlighted and has the potential to detect new biomarkers, identify therapeutic targets, and generate patient-specific predictive models of clinical outcomes in solid organ transplantation.
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Maternal and neonatal immune response to SARS-CoV-2, IgG transplacental transfer and cytokine profile
Rocío Rubio,Ruth Aguilar,Mariona Bustamante,Érica Muñoz,Miquel Vázquez-Santiago,Rebeca Santano,Marta Vidal,Natalia Rodrigo Melero,Daniel Parras,Pau Serra,Pere Santamaria,Carlo Carolis,Luis Izquierdo,María Dolores Gómez-Roig,Carlota Dobaño,Gemma Moncunill,Edurne Mazarico +16 more
TL;DR: Intervention during the third trimester of pregnancy induces a robust antibody and cytokine response at delivery and causes a significant reduction of the SARS-CoV-2-specific IgGs transplacental transfer, with a stronger negative effect when the infection is closer to delivery.
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