An immune clock of human pregnancy.
Nima Aghaeepour,Edward A. Ganio,David R. McIlwain,Amy S. Tsai,Martha Tingle,Sofie Van Gassen,Dyani Gaudilliere,Quentin Baca,Leslie McNeil,Robin Okada,Mohammad Sajjad Ghaemi,David Furman,David Furman,Ronald J. Wong,Virginia D. Winn,Maurice L. Druzin,Yaser Y. El-Sayed,Cecele C. Quaintance,Ronald S. Gibbs,Gary L. Darmstadt,Gary M. Shaw,David K. Stevenson,Robert Tibshirani,Garry P. Nolan,David B. Lewis,Martin S. Angst,Brice Gaudilliere +26 more
TLDR
These findings unravel the precise timing of immunological events occurring during a term pregnancy and provide the analytical framework to identify immunological deviations implicated in pregnancy-related pathologies.Abstract:
The maintenance of pregnancy relies on finely tuned immune adaptations. We demonstrate that these adaptations are precisely timed, reflecting an immune clock of pregnancy in women delivering at term. Using mass cytometry, the abundance and functional responses of all major immune cell subsets were quantified in serial blood samples collected throughout pregnancy. Cell signaling-based Elastic Net, a regularized regression method adapted from the elastic net algorithm, was developed to infer and prospectively validate a predictive model of interrelated immune events that accurately captures the chronology of pregnancy. Model components highlighted existing knowledge and revealed previously unreported biology, including a critical role for the interleukin-2-dependent STAT5ab signaling pathway in modulating T cell function during pregnancy. These findings unravel the precise timing of immunological events occurring during a term pregnancy and provide the analytical framework to identify immunological deviations implicated in pregnancy-related pathologies.read more
Citations
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Pregnancy-specific responses to COVID-19 are revealed by high-throughput proteomics of human plasma
Nardhy Gomez-Lopez,Roberto Romero,Maria Cabrera Escobar,J. Carvajal,María Paula Echavarría,Ludwig L Albornoz,Daniela Nasner,Derek Miller,Dahiana Gallo,Jose Galaz,Marcia Arenas-Hernandez,Gaurav Bhatti,Bogdan Done,M. Zambrano,Isabella Ramos,Paula Andrea Fernández,Leandro Posada,Tinnakorn Chaiworapongsa,Eun Jung Jung,Valeria Garcia-Flores,Manaphat Suksai,Francesca Gotsch,Maria Camila Bandeira Seixas Bosco,Nandor Gabor Than,Adi L. Tarca +24 more
TL;DR: In this paper , a comprehensive characterization of the plasma proteome of pregnant and non-pregnant COVID-19 patients was performed using the SOMAmer platform, which revealed that pregnant women display a tailored response that may protect the conceptus from heightened inflammation, while non-Pregnant individuals display a stronger response to repel infection.
Journal ArticleDOI
Leukocyte telomere dynamics across gestation in uncomplicated pregnancies and associations with stress
Danielle M. Panelli,Stephanie A. Leonard,Ronald J. Wong,Martin Becker,Jonathan A. Mayo,Erica Wu,Anna I. Girsen,Ian H. Gotlib,Nima Aghaeepour,Maurice L. Druzin,Gary M. Shaw,David K. Stevenson,Katherine Bianco +12 more
TL;DR: In this paper , the authors examined changes in maternal leukocyte telomere length (LTL) during uncomplicated pregnancies and explored correlations with perceived stress in a pilot study.
Journal ArticleDOI
Is the Modified Distress Thermometer Useful for Screening Pregnant Women With COVID-19 for Psychological Distress?
TL;DR: With the use of the modified distress thermometer, two-thirds of pregnant women with COVID-19 experienced significant distress, significantly related to older age, multigravida, exposure to longer quarantine time, presence of underlying medical disorder, and the presence of chronic respiratory disorders.
Journal ArticleDOI
Prediction of gestational age using urinary metabolites in term and preterm pregnancies
Kévin Contrepois,Songjie Chen,Mohammad Sajjad Ghaemi,Ronald J. Wong,Fyezah Jehan,Sunil Sazawal,Abdullah H Baqui,Jeffrey S. A. Stringer,Anisur Rahman,Muhammad Imran Nisar,Usha Dhingra,Rasheda Khanam,Muhammad Ilyas,Arup Dutta,Usma Mehmood,Saikat Deb,Aneeta Hotwani,Said M. Ali,Sayed Wahidur Rahman,Ambreen Nizar,Shaali M. Ame,Sajid Muhammad,Aishwarya Chauhan,Waqasuddin Khan,Rubhana Raqib,Sayan Das,Sala Uddin Ahmed,Tarik Hasan,Javairia Khalid,Mohammed Hamad Juma,Nabidul H. Chowdhury,Furqan Kabir,Fahad Aftab,Alexander Manu,Sachiyo Yoshida,Rajiv Bahl,Jesmin Pervin,Joan T. Price,Monjur Rahman,Margaret P Kasaro,James A. Litch,Patrick Musonda,Bellington Vwalika,Abdul Quaiyum,Gary M. Shaw,David K. Stevenson,Nima Aghaeepour,Michael Snyder +47 more
TL;DR: In this paper , the ability of urinary metabolites to predict gestational age at time of collection in a diverse multi-site cohort of healthy and pathological pregnancies (n = 99) using a broad-spectrum liquid chromatography coupled with mass spectrometry (LC-MS) platform was investigated.
Journal ArticleDOI
Protein Concentrations of Thrombospondin-1, MIP-1β, and S100A8 Suggest the Reflection of a Pregnancy Clock in Mid-Trimester Amniotic Fluid
Felicia Viklund,Maria Hallingström,Maria Hallingström,Marian Kacerovsky,Teresa Cobo,Kristin Skogstrand,David M. Hougaard,Karin Sävman,Karin Sävman,Ylva Carlsson,Ylva Carlsson,Panagiotis Tsiartas,Panagiotis Tsiartas,Julius Juodakis,Julius Juodakis,Staffan Nilsson,Staffan Nilsson,Bo Jacobsson,Bo Jacobsson +18 more
TL;DR: These findings suggest that the concept of a pregnancy clock is also reflected in the amniotic fluid at early mid-trimester, but further research is needed to confirm this.
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