An immune clock of human pregnancy.
Nima Aghaeepour,Edward A. Ganio,David R. McIlwain,Amy S. Tsai,Martha Tingle,Sofie Van Gassen,Dyani Gaudilliere,Quentin Baca,Leslie McNeil,Robin Okada,Mohammad Sajjad Ghaemi,David Furman,David Furman,Ronald J. Wong,Virginia D. Winn,Maurice L. Druzin,Yaser Y. El-Sayed,Cecele C. Quaintance,Ronald S. Gibbs,Gary L. Darmstadt,Gary M. Shaw,David K. Stevenson,Robert Tibshirani,Garry P. Nolan,David B. Lewis,Martin S. Angst,Brice Gaudilliere +26 more
TLDR
These findings unravel the precise timing of immunological events occurring during a term pregnancy and provide the analytical framework to identify immunological deviations implicated in pregnancy-related pathologies.Abstract:
The maintenance of pregnancy relies on finely tuned immune adaptations. We demonstrate that these adaptations are precisely timed, reflecting an immune clock of pregnancy in women delivering at term. Using mass cytometry, the abundance and functional responses of all major immune cell subsets were quantified in serial blood samples collected throughout pregnancy. Cell signaling-based Elastic Net, a regularized regression method adapted from the elastic net algorithm, was developed to infer and prospectively validate a predictive model of interrelated immune events that accurately captures the chronology of pregnancy. Model components highlighted existing knowledge and revealed previously unreported biology, including a critical role for the interleukin-2-dependent STAT5ab signaling pathway in modulating T cell function during pregnancy. These findings unravel the precise timing of immunological events occurring during a term pregnancy and provide the analytical framework to identify immunological deviations implicated in pregnancy-related pathologies.read more
Citations
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The Immunological Role of the Placenta in SARS-CoV-2 Infection-Viral Transmission, Immune Regulation, and Lactoferrin Activity.
TL;DR: In this paper, a review summarizes the current knowledge on the anti-viral activity of lactoferrin during viral infection in pregnant women, analyzes its role in the pathogenicity of pandemic virus particles, and describes the potential evidence for placental blocking/limiting of the transmission of the virus.
Journal ArticleDOI
Functional and genomic adaptations of blood monocytes to pregravid obesity during pregnancy.
Suhas Sureshchandra,Nicole Marshall,Norma Mendoza,Allen Jankeel,Michael Z. Zulu,Ilhem Messaoudi +5 more
TL;DR: In this article, the authors profiled circulating immune mediators, immune cell subset frequencies, and peripheral immune responses during the first and third trimesters of pregnancy in lean and obese mothers.
Journal ArticleDOI
Changes in peripheral immune populations during pregnancy and modulation by probiotics and ω-3 fatty acids.
TL;DR: Probiotic supplementation to the mother during the second half of pregnancy resulted in immunomodulatory effects among activated and resting Treg cells and several systemic immune modifying effects of pregnancy were observed.
Journal ArticleDOI
The Effects of Maternal Interleukin-17A on Social Behavior, Cognitive Function, and Depression-Like Behavior in Mice with Altered Kynurenine Metabolites:
Yuki Murakami,Yukio Imamura,Yukio Imamura,Yoshiyuki Kasahara,Chihiro Yoshida,Yuta Momono,Ke Fang,Toshimasa Nishiyama,Daisuke Sakai,Yukuo Konishi +9 more
TL;DR: In this article, the effects of high maternal concentration of kynurenine on offspring were investigated by continuously administering mouse dams with kynuranine from embryonic day 12.5 during gestation.
Journal ArticleDOI
Nutrition as Personalized Medicine against SARS-CoV-2 Infections: Clinical and Oncological Options with a Specific Female Groups Overview
Miriam Dellino,Eliano Cascardi,Marina Vinciguerra,Bruno Lamanna,Antonio Malvasi,Salvatore Scacco,Silvia Acquaviva,Vincenzo Pinto,Giovanni Di Vagno,Gennaro Cormio,Raffaele De Luca,Miria Lafranceschina,G. Cazzato,Giuseppe Ingravallo,Eugenio Maiorano,Leonardo Resta,Antonella Daniele,Daniele La Forgia +17 more
TL;DR: This review explores the power of nutrition in the immune response against COVID-19 infection, since a specific diet could modify the cytokine storm during the infection phase.
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