An immune clock of human pregnancy.
Nima Aghaeepour,Edward A. Ganio,David R. McIlwain,Amy S. Tsai,Martha Tingle,Sofie Van Gassen,Dyani Gaudilliere,Quentin Baca,Leslie McNeil,Robin Okada,Mohammad Sajjad Ghaemi,David Furman,David Furman,Ronald J. Wong,Virginia D. Winn,Maurice L. Druzin,Yaser Y. El-Sayed,Cecele C. Quaintance,Ronald S. Gibbs,Gary L. Darmstadt,Gary M. Shaw,David K. Stevenson,Robert Tibshirani,Garry P. Nolan,David B. Lewis,Martin S. Angst,Brice Gaudilliere +26 more
TLDR
These findings unravel the precise timing of immunological events occurring during a term pregnancy and provide the analytical framework to identify immunological deviations implicated in pregnancy-related pathologies.Abstract:
The maintenance of pregnancy relies on finely tuned immune adaptations. We demonstrate that these adaptations are precisely timed, reflecting an immune clock of pregnancy in women delivering at term. Using mass cytometry, the abundance and functional responses of all major immune cell subsets were quantified in serial blood samples collected throughout pregnancy. Cell signaling-based Elastic Net, a regularized regression method adapted from the elastic net algorithm, was developed to infer and prospectively validate a predictive model of interrelated immune events that accurately captures the chronology of pregnancy. Model components highlighted existing knowledge and revealed previously unreported biology, including a critical role for the interleukin-2-dependent STAT5ab signaling pathway in modulating T cell function during pregnancy. These findings unravel the precise timing of immunological events occurring during a term pregnancy and provide the analytical framework to identify immunological deviations implicated in pregnancy-related pathologies.read more
Citations
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Multiomic signals associated with maternal epidemiological factors contributing to preterm birth in low- and middle-income countries
Camilo Espinosa,Waqasuddin Khan,Rasheda Khanam,Sayan Das,Javairia Khalid,Jesmin Pervin,Margaret P Kasaro,Kévin Contrepois,Alan L. Chang,Thanaphong Phongpreecha,Basil Michael,Mathew Ellenberger,Usma Mehmood,Aneeta Hotwani,Ambreen Nizar,Furqan Kabir,Ronald J. Wong,Martin Becker,Eloiise Berson,Anthony Culos,Davide De Francesco,Samson Mataraso,Neal G Ravindra,Melan Thuraiappah,Maria Xenochristou,Ina A. Stelzer,Ivana Maric,Arup Dutta,Rubhana Raqib,Sala Uddin Ahmed,Sayed Wahidur Rahman,Azimi Hasan,Said M. Ali,Mohamed Hamad Juma,Monjur Rahman,Shaki Aktar,Saikat Deb,Joan T. Price,Paul H. Wise,Virginia D. Winn,Maurice L. Druzin,Ronald S. Gibbs,Gary L. Darmstadt,Jeffrey C. Murray,Jeffrey S. A. Stringer,Brice Gaudilliere,Michael Snyder,Martin S. Angst,Anisur Rahman,Abdullah H Baqui,Fyezah Jehan,Muhammad Imran Nisar,Bellington Vwalika,Sunil Sazawal,Gary M. Shaw,David K. Stevenson,Nima Aghaeepour +56 more
TL;DR: In this paper , the authors used multi-omic profiling and multivariate modeling to investigate the biological signatures of preterm birth (PTB) characteristics, including maternal age, time-to-delivery, gravidity and BMI.
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An inexpensive semi-automated sample processing pipeline for cell-free RNA
TL;DR: A low-cost, semi-automated pipeline to extract cell-free RNA (cfRNA) that increases sample throughput by 12-fold while reducing time spent and cost by nearly 11-fold and 3-fold respectively is described.
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Linking Electronic Health Records With Wearable Technology From the All of Us Research Program.
TL;DR: In this article , the authors evaluated the feasibility of using electronic health records (EHRs) and wearable data to describe patterns of longitudinal change in day-level heart rate before, during, and after pregnancy and how these patterns differ by age and body mass index.
Journal ArticleDOI
Pregnancy-specific responses to COVID-19 revealed by high-throughput proteomics of human plasma
Nardhy Gomez-Lopez,Roberto Romero,María Fernanda Escobar,Javier Andrés Carvajal,María Paula Echavarría,Ludwig L Albornoz,Daniela Nasner,Derek Miller,Dahiana Gallo,Jose Galaz,Marcia Arenas-Hernandez,Gaurav Bhatti,Bogdan Done,Maria Andrea Zambrano,Isabella Ramos,Paula Andrea Fernández,Leandro Posada,Tinnakorn Chaiworapongsa,Eun Jung Jung,Valeria Garcia-Flores,Manaphat Suksai,Francesca Gotsch,Maria Caria Bosco,Nandor Gabor Than,Adi L. Tarca +24 more
TL;DR: In this paper , a comprehensive characterization of the plasma proteome of pregnant and non-pregnant COVID-19 patients was performed using the SOMAmer platform, which revealed that pregnant women display a tailored response that may protect the conceptus from heightened inflammation, while non-Pregnant individuals display a stronger response to repel infection.
Posted ContentDOI
Pregnancy-specific responses to COVID-19 are revealed by high-throughput proteomics of human plasma
TL;DR: In this paper , a comprehensive characterization of the plasma proteome of pregnant and non-pregnant COVID-19 patients and controls was presented, and shared and pregnancy-specific proteomic changes were identified: pregnant women display a tailored response that may protect the conceptus from heightened inflammation, while nonsmokers display a stronger response to repel infection.
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