An overview of potential novel mechanisms of action underlying Tumor Treating Fields-induced cancer cell death and their clinical implications
TLDR
This review focuses on potentially novel mechanisms of TTFields anti-tumor action and their implications in completed and ongoing clinical trials and pre-clinical studies, and discusses advantages and strategies using chemotherapy agents and radiation therapy in combination with TTF yields for future clinical use.Abstract:
Traditional cancer therapy choices for clinicians are surgery, chemotherapy, radiation and immune therapy which are used either standalone therapies or in various combinations. Other physical modal...read more
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Journal ArticleDOI
Permeabilizing Cell Membranes with Electric Fields.
Alondra A. Aguilar,Michelle Ho,Edwin Chang,Kristen W. Carlson,Arutselvan Natarajan,Tal Marciano,Zeev Bomzon,Chirag B. Patel +7 more
TL;DR: In this paper, the authors provide an overview of the standard mechanism of action of TTFields, namely, the capability for AEFs to disrupt the formation and segregation of the mitotic spindle in actively dividing cells.
Journal ArticleDOI
Challenges in glioblastoma research: focus on the tumor microenvironment.
Andreas Bikfalvi,Cristine Alves da Costa,Tony Avril,Jean-Vianney Barnier,Luc Bauchet,Lucie Brisson,Pierre-François Cartron,Hélène Castel,Eric Chevet,Hervé Chneiweiss,Anne Clavreul,B. Constantin,Valérie Coronas,Thomas Daubon,Monique Dontenwill,François Ducray,Natacha Enz-Werle,Dominique Figarella-Branger,Isabelle Fournier,Jean-Sebastien Frenel,Mathieu Gabut,Thierry Galli,Julie Gavard,Gilles Huberfeld,Jean-Philippe Hugnot,Ahmed Idbaih,Marie-Pierre Junier,Thomas Mathivet,Philippe Menei,David Meyronet,Céline Mirjolet,Fabrice Morin,Jean Mosser,Elizabeth Cohen-Jonathan Moyal,D. Rousseau,Michel Salzet,Marc Sanson,Giorgio Seano,Emeline Tabouret,Aurélie Tchoghandjian,Laurent Turchi,François M. Vallette,Somya Vats,Maite Verreault,Thierry Virolle +44 more
TL;DR: In this paper , a comprehensive report of the GBM TME is provided, which assembles the contributions of physicians and translational researchers working on brain tumor pathology and therapy in France.
Journal ArticleDOI
Tumor Treating Fields Suppression of Ciliogenesis Enhances Temozolomide Toxicity
TL;DR: In this article , the authors found that TTFields ablated cilia within 24 hours of treatment with TMZ and ARL13B+ cilia was partially rescued by chloroquine pretreatment, suggesting the effect is in part due to autophagy activation.
Journal ArticleDOI
The Mechanisms of Action of Tumor Treating Fields
Justin C. Moser,Ellaine Salvador,Karina Deniz,Kenneth Swanson,Jack Tusynski,Kristen W. Carlson,Narasimha Kumar Karanam,Chirag B. Patel,Michael D. Story,Emil Lou,Carsten Hagemann +10 more
TL;DR: Tumor Treating Fields are electric fields transmitted transdermally to tumors that have the ability to be useful for many cancer types in combination with many different treatment modalities.
Journal ArticleDOI
The Mechanisms of Action of Tumor Treating Fields
TL;DR: Tumor Treating Fields (TTFields) as discussed by the authors are a new modality of cancer treatment, which are electric fields transmitted transdermally to tumors, and they are currently under study in many other cancer types.
References
More filters
Journal ArticleDOI
Cellular processing of platinum anticancer drugs.
Dong Wang,Stephen J. Lippard +1 more
TL;DR: This review focuses on recently discovered cellular pathways that are activated in response to cisplatin, including those involved in regulating drug uptake, the signalling of DNA damage, cell-cycle checkpoints and arrest, DNA repair and cell death.
Journal ArticleDOI
Hallmarks of 'BRCAness' in sporadic cancers
TL;DR: There are properties that define 'BRCAness' — that is, traits that some sporadic cancers share with those occurring in either BRCA1- or BRCa2-mutation carriers, which might have important implications for the clinical management of these cancers.
Journal ArticleDOI
Effect of Tumor-Treating Fields Plus Maintenance Temozolomide vs Maintenance Temozolomide Alone on Survival in Patients With Glioblastoma: A Randomized Clinical Trial
Roger Stupp,Roger Stupp,Roger Stupp,Sophie Taillibert,Sophie Taillibert,Andrew A. Kanner,William L. Read,William L. Read,David M. Steinberg,Benoit Lhermitte,Steven A. Toms,Ahmed Idbaih,Manmeet Ahluwalia,Karen Fink,Francesco Di Meco,Frank S. Lieberman,Jay-Jiguang Zhu,Jay-Jiguang Zhu,Giuseppe Stragliotto,David Tran,Steven Brem,Steven Brem,Andreas F. Hottinger,Eilon D. Kirson,Gitit Lavy-Shahaf,Uri Weinberg,Chae-Yong Kim,Sun Ha Paek,Garth Nicholas,Jordi Burna,H Hirte,Michael Weller,Yoram Palti,Monika E. Hegi,Zvi Ram +34 more
TL;DR: In the final analysis of this randomized clinical trial of patients with glioblastoma who had received standard radiochemotherapy, the addition of TTFields to maintenance temozolomide chemotherapy vs maintenance Temozolmide alone, resulted in statistically significant improvement in progression-free survival and overall survival.
Journal ArticleDOI
The Concept of Synthetic Lethality in the Context of Anticancer Therapy
TL;DR: Synthetic lethality provides a conceptual framework for the development of cancer-specific cytotoxic agents and has not been exploited in the past because there were no robust methods for systematically identifying synthetic lethal genes.
Journal ArticleDOI
Maintenance therapy with tumor-Treating fields plus temozolomide vs temozolomide alone for glioblastoma a randomized clinical trial
Roger Stupp,Roger Stupp,S. Taillibert,Andrew A. Kanner,Santosh Kesari,David M. Steinberg,Steven A. Toms,Lynne P. Taylor,Frank S. Lieberman,Antonio Silvani,Karen Fink,Gene H. Barnett,Jay-Jiguang Zhu,John W. Henson,Herbert H. Engelhard,Thomas C. Chen,David Tran,Jan Sroubek,Nam D. Tran,Andreas F. Hottinger,Joseph Landolfi,Rajiv D. Desai,Manuela Caroli,Yvonne Kew,Jérôme Honnorat,Ahmed Idbaih,Eilon D. Kirson,Uri Weinberg,Yoram Palti,Monika E. Hegi,Zvi Ram +30 more
TL;DR: In this interim analysis of 315 patients with glioblastoma who had completed standard chemoradiation therapy, adding TTFields to maintenance temozolomide chemotherapy significantly prolonged progression-free and overall survival.
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